Dana Kralisch

Ginsenosides from Panax ginseng modulate lipid mediator profiles in human leukocytes by interference with cellular 5-lipoxygenase activity

Vera Bruggink, Alissa Decker, Uwe Beekmann, Dana Kralisch et autres

Lipid mediators are a superfamily of bioactive molecules that are crucially involved in immune responses, regulating all stages of inflammation. Panax (P.) ginseng has pleiotropic pharmacological effects, including anti-cancer, anti-diabetic, and anti-inflammatory properties. Ginsenosides, unique triterpenoid glycosides from the plant’s root, are …

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Biosynthetische Cellulose in der modernen Wundversorgung

Dana Kralisch, Paul Zahel

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Exploring Microemulsion Systems for the Incorporation of Glucocorticoids into Bacterial Cellulose: A Novel Approach for Anti-Inflammatory Wound Dressings

Paul Zahel, Vera Bruggink, Juliana Hülsmann, Frank Steiniger et autres

The effective pharmacological treatment of inflamed wounds such as pyoderma gangraenosum remains challenging, as the systemic application of suitable drugs such as glucocorticoids is compromised by severe side effects and the inherent difficulties of wounds as drug targets. Furthermore, conventional semi-solid formulations …

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In situ Formation of Polymer Microparticles in Bacterial Nanocellulose Using Alternative and Sustainable Solvents to Incorporate Lipophilic Drugs

Tom Bellmann, Jana Thamm, Uwe Beekmann, Dana Kralisch et autres

Bacterial nanocellulose has been widely investigated in drug delivery, but the incorporation of lipophilic drugs and controlling release kinetics still remain a challenge. The inclusion of polymer particles to encapsulate drugs could address both problems but is reported sparely. In the present …

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Bacterial nanocellulose patches as a carrier for hydrating formulations to improve the topical treatment of nail diseases

Tom Bellmann, Ruth Luber, Lisa Kischio, Berit Karl et autres

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Bacterial Cellulose as Drug Delivery System for Optimizing Release of Immune Checkpoint Blocking Antibodies

Chih Kit Chung, Uwe Beekmann, Dana Kralisch, Katja Bierau et autres

Immune checkpoint blocking therapy is a promising cancer treatment modality, though it has limitations such as systemic toxicity, which can often be traced to uncontrolled antibody spread. Controlling antibody release with delivery systems is, therefore, an attractive approach to reduce systemic antibody …

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Bacterial Cellulose—Adaptation of a Nature-Identical Material to the Needs of Advanced Chronic Wound Care

Paul Zahel, Uwe Beekmann, Thomas Eberlein, Michael Schmitz et autres

Modern wound treatment calls for hydroactive dressings. Among the variety of materials that have entered the field of wound care in recent years, the carbohydrate polymer bacterial cellulose (BC) represents one of the most promising candidates as the biomaterial features a high …

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Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing

Jessica Hoff, Berit Karl, Jana Gerstmeier, Uwe Beekmann et autres

Inflammation is a hallmark of tissue remodeling during wound healing. The inflammatory response to wounds is tightly controlled and well-coordinated; dysregulation compromises wound healing and causes persistent inflammation. Topical application of natural anti-inflammatory products may improve wound healing, in particular under chronic …

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Modified Bacterial Cellulose Dressings to Treat Inflammatory Wounds

Uwe Beekmann, Paul Zahel, Berit Karl, Lisa Schmölz et autres

Natural products suited for prophylaxis and therapy of inflammatory diseases have gained increasing importance. These compounds could be beneficially integrated into bacterial cellulose (BC), which is a natural hydropolymer applicable as a wound dressing and drug delivery system alike. This study presents …

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Overcoming the hydrophilicity of bacterial nanocellulose: Incorporation of the lipophilic coenzyme Q10 using lipid nanocarriers for dermal applications

Yaser Alkhatib, Gabriele Blume, Jana Thamm, Frank Steiniger et autres

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The nanocellulose family

Dieter Klemm, Tom Lindström, Tíffany Abitbol, Dana Kralisch

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Contributors

Tíffany Abitbol, Aaliah Aly, V.P. Anju, Pratheep K. Annamalai et autres

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