Lisa Schmölz

α‐Tocopherol Long‐Chain Metabolite α‐T‐13′‐COOH Exhibits Biphasic Effects on Cell Viability, Induces ROS‐Dependent DNA Damage, and Modulates Redox Status in Murine RAW264.7 Macrophages

Sijia Liao, Lisa Börmel, Anke Katharina Müller, L R Gottschalk et autres

SCOPE: The α-tocopherol long-chain metabolite α-tocopherol-13'-hydroxy-chromanol (α-T-13'-COOH) is a proposed regulatory intermediate of endogenous vitamin E metabolism. Effects of α-T-13'-COOH on cell viability and adaptive stress response are not well understood. The present study aims to investigate the concentration-dependent effects of α-T-13'-COOH …

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Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing

Jessica Hoff, Berit Karl, Jana Gerstmeier, Uwe Beekmann et autres

Inflammation is a hallmark of tissue remodeling during wound healing. The inflammatory response to wounds is tightly controlled and well-coordinated; dysregulation compromises wound healing and causes persistent inflammation. Topical application of natural anti-inflammatory products may improve wound healing, in particular under chronic …

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Modified Bacterial Cellulose Dressings to Treat Inflammatory Wounds

Uwe Beekmann, Paul Zahel, Berit Karl, Lisa Schmölz et autres

Natural products suited for prophylaxis and therapy of inflammatory diseases have gained increasing importance. These compounds could be beneficially integrated into bacterial cellulose (BC), which is a natural hydropolymer applicable as a wound dressing and drug delivery system alike. This study presents …

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Induced Production, Synthesis, and Immunomodulatory Action of Clostrisulfone, a Diarylsulfone from Clostridium acetobutylicum

Toni Neuwirth, Anne‐Catrin Letzel, Cedric Tank, Keishi Ishida et autres

The anaerobe Clostridium acetobutylicum belongs to the most important industrially used bacteria. Whereas genome mining points to a high potential for secondary metabolism in C. acetobutylicum, the functions of most biosynthetic gene clusters are cryptic. We report that the addition of supra-physiological …

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Process control and scale-up of modified bacterial cellulose production for tailor-made anti-inflammatory drug delivery systems

Uwe Beekmann, Lisa Schmölz, Stefan Lorkowski, Oliver Werz et autres

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The vitamin E derivative garcinoic acid from Garcinia kola nut seeds attenuates the inflammatory response

Maria Wallert, Julia Bauer, Stefan Kluge, Lisa Schmölz et autres

The plant Garcinia kola is used in African ethno-medicine to treat various oxidation- and inflammation-related diseases but its bioactive compounds are not well characterized. Garcinoic acid (GA) is one of the few phytochemicals that have been isolated from Garcinia kola . We …

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In Vitro Digested Nut Oils Attenuate the Lipopolysaccharide-Induced Inflammatory Response in Macrophages

Anke Katharina Müller, Lisa Schmölz, Maria Wallert, M. Schubert et autres

Nut consumption is known for its health benefits, in particular in inflammatory diseases. A possible mechanism for these effects could be their beneficial fatty acid composition. Nuts mainly contain mono- and polyunsaturated fatty acids, which have anti-inflammatory properties. However, studies investigating the …

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Bioactivity of Vitamin E Long-Chain Metabolites

Stefan Kluge, M. Schubert, Lisa Schmölz, Maria Wallert et autres

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The Hepatic Fate of Vitamin E

Lisa Schmölz, M. Schubert, Stefan Kluge, Marc Birringer et autres

Vitamin E is a lipophilic vitamin and thus is naturally occurring mainly in high-fat plant products such as oils, nuts, germs, seeds, and in lower amounts in vegetables and some fruits. The term “vitamin E” comprises different structures that are classified as …

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Long-chain metabolites of vitamin E: Interference with lipotoxicity via lipid droplet associated protein PLIN2

Lisa Schmölz, M. Schubert, Jasmin Kirschner, Stefan Kluge et autres

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Long-Chain Metabolites of Vitamin E: Metabolic Activation as a General Concept for Lipid-Soluble Vitamins?

M. Schubert, Stefan Kluge, Lisa Schmölz, Maria Wallert et autres

Vitamins E, A, D and K comprise the class of lipid-soluble vitamins. For vitamins A and D, a metabolic conversion of precursors to active metabolites has already been described. During the metabolism of vitamin E, the long-chain metabolites (LCMs) 13'-hydroxychromanol (13'-OH) and …

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In-vitro-Studien zur Charakterisierung der biologischen Funktion langkettiger Vitamin-E-Metaboliten

Lisa Schmölz

Der Metabolismus von Vitamin E ist seit den 1980er Jahren des vergangenen Jahrhunderts bekannt, wobei die ersten Abbauprodukte, die langkettigen Vitamin-E-Metabolite (long-chain metabolites, LCM), erst im Jahr 2002 beschrieben wurden. In der vorliegenden Arbeit wird mit Hilfe von drei Übersichtsarbeiten der Einstieg …