Simone Mozzachiodi

Network-scale disruption of RNA-protein interactions by a bioaccumulating small-molecule drug

Xiaoteng Jiang, Simone Mozzachiodi, Indra Roux, Mehul Makwana et autres

Abstract Many small-molecule drugs accumulate in both host and gut microbial cells. Yet, the molecular consequences of intracellular drug accumulation are largely unknown. Here we show that the antidepressant duloxetine broadly disrupts RNA-protein interactions revealing a previously unrecognized mode of drug effect. …

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Laboratory evolution enhances resilience of a symbiont yeast and its honeybee host against agrochemical exposure

Simone Mozzachiodi, Flavia Di Cesare, Stephan Kamrad, Xiaoteng Jiang et autres

Yeasts are key microbial members of several ecosystems. Yet, the impact of widespread chemical pollutants on yeasts is only sparsely studied. Here we report the effect of >1000 chemical pollutants on fourteen diverse yeast species spanning the Saccharomycotina subphylum. Starmerella bombicola , …

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Common xenobiotics modulate gut microbial responses to low‑calorie sweeteners in vitro

Sonja Blasche, Vinita Periwal, Nonantzin Beristain Covarrubias, Anna E. Lindell et autres

The gut microbiota is implicated in adverse effects associated with low-calorie sweeteners. Yet, the direct impact of sweeteners on gut bacteria remains largely uncharacterized. Here, we report interactions between 25 phylogenetically diverse gut bacterial strains and 39 commercially used sweeteners. We tested …

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Interspecies interactions drive bacterial proteome reorganization and emergent metabolism

Stephan Kamrad, Simran Kaur Aulakh, Simone Mozzachiodi, Sonja Blasche et autres

Species in microbial communities need to stave off competition and capitalize on new resources that become available because of metabolic activities of others. However, intra-cellular molecular changes that underpin these responses are understudied, preventing mechanistic insights into community function and dynamics. Here …

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Non-model microbes and microbial communities: opportunities for biotechnology.

Sonja Blasche, Simone Mozzachiodi, Indra Roux, Kiran Raosaheb Patil

Non-model microbes and microbial communities: opportunities for biotechnology

Sonja Blasche, Simone Mozzachiodi, Indra Roux, Kiran Raosaheb Patil

Microbiology research is expanding from model species to non-model species and from studying single-species phenotypes to microbiomes and emergent functions. Here, we review the biotechnological opportunities brought forward by this expansion. Omics and automation have expanded the catalogue of non-model microbes that …

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Interspecies interactions drive bacterial proteome reorganisation and emergent metabolism

Stephan Kamrad, Simone Mozzachiodi, Sonja Blasche, Simran Kaur Aulakh et autres

Abstract Species in microbial communities must respond to the presence of others to stave off resource competition or to capitalise on new resources that may become available due to additional metabolic activities. Such metabolic interactions manifest in growth effects such as competitive …

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Ancient and recent origins of shared polymorphisms in yeast

Nicolò Tellini, Matteo De Chiara, Simone Mozzachiodi, Lorenzo Tattini et autres

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Ancient and recent origins of shared polymorphisms in yeast

Nicolò Tellini, Matteo De Chiara, Simone Mozzachiodi, Lorenzo Tattini et autres

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Evolution of yeast hybrids by aborted meiosis

Simone Mozzachiodi, Gianni Liti

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Unlocking the functional potential of polyploid yeasts

Simone Mozzachiodi, Kristoffer Krogerus, Brian R. Gibson, Alain G. Nicolas et autres

Breeding and domestication have generated widely exploited crops, animals and microbes. However, many Saccharomyces cerevisiae industrial strains have complex polyploid genomes and are sterile, preventing genetic improvement strategies based on breeding. Here, we present a strain improvement approach based on the budding …

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Yeasts from temperate forests

Simone Mozzachiodi, Feng‐Yan Bai, Petr Baldrián, Graham Bell et autres

Yeasts are ubiquitous in temperate forests. While this broad habitat is well-defined, the yeasts inhabiting it and their life cycles, niches, and contributions to ecosystem functioning are less understood. Yeasts are present on nearly all sampled substrates in temperate forests worldwide. They …

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