Cezary Skobowiat

Tinea Versicolor (Pityriasis Versicolor)

Matteo Zanardelli, Cezary Skobowiat, Rafal Kaliszuk, Aldona Pietrzak

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The Role of Neuromediators in Skin Conditions

Cezary Skobowiat, Radomir M. Slominski, Andrzej T. Slominski

The skin has evolved to protect the internal body integrity against environmental stressors. This protection is assured by a fully functional epidermal barrier defined by structural and functional elements. The skin also serves as an amiable environment for the nervous, immune, endocrine, …

Safety and efficacy of a novel three-step anti-acne regimen formulated specifically for women

Timothy J. Falla, Katie Rodan, Kathy Fields, Danielle Ong et autres

BACKGROUND: Due to ambient environmental- and lifestyle-associated stressors, the prevalence of acne in adult women has been increasing. Classical anti-acne treatments using benzoyl peroxide technology are associated with dehydration of the skin, which may accelerate aging and further reduce treatment compliance. The …

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LB946 Improvements in acne-prone skin quality correlate with a reduction in saliva cortisol levels after use of an 8-week 3-step topical regimen

Cezary Skobowiat, J. Craw, Rodolfo Bianchini, Kathy Fields et autres

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New effects of caffeine on corticotropin‐releasing hormone (CRH)‐induced stress along the intrafollicular classical hypothalamic–pituitary–adrenal (HPA) axis (CRH‐R1/2, IP3‐R, ACTH, MC‐R2) and the neurogenic non‐HPA axis (substance P, p75NTRand TrkA) inex vivohuman male androgenetic scalp hair follicles

Tobias W. Fischer, A. Bergmann, Nathalie Kruse, Konrad Kleszczyński et autres

Human hair is highly responsive to stress, and human scalp hair follicles (HFs) contain a peripheral neuroendocrine equivalent of the systemic hypothalamic–pituitary–adrenal (HPA) stress axis. Androgenetic alopecia (AGA) is supposed to be aggravated by stress. We used corticotropin‐releasing hormone (CRH), which triggers …

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Characterization of serotonin and N ‐acetylserotonin systems in the human epidermis and skin cells

Andrzej T. Slominski, Tae‐Kang Kim, Konrad Kleszczyński, Igor V. Semak et autres

Abstract Tryptophan hydroxylase (TPH) activity was detected in cultured epidermal melanocytes and dermal fibroblasts with respective Km of 5.08 and 2.83 mM and Vmax of 80.5 and 108.0 µmol/min. Low but detectable TPH activity was also seen in cultured epidermal keratinocytes. Serotonin …

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Novel interpenetrating polymer network provides significant and long‐lasting improvements in hydration to the skin from different body areas

Timothy J. Falla, Katie Rodan, Kathy Fields, Robert Bianchini et autres

BACKGROUND: Hydration and moisturization both impact skin quality, directly reflecting its appearance. Signs and onset of dehydration-related skin aging are region-specific and require tailored treatment to be effective. AIMS: To test the hydrating effects of formulas containing a novel 3-dimensional 3-polymer interpenetrating …

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Effect of a Tranexamic Acid, Kojic Acid, and Niacinamide Containing Serum on Facial Dyschromia: A Clinical Evaluation

Seemal R. Desai, Eloísa Leis Ayres, Hana Bak, Megan C. Manco et autres

Background: Stubborn dyschromia such as melasma and post-inflammatory hyperpigmentation (PIH) are leading causes for cosmetic consultation. Topical treatment is challenging, using a range of modalities, to stop, hinder, and/or prevent steps in the pigment production process. Tranexamic acid (TXA), a potent plasmin …

859 Evaluation of Kojic Acid and Hydroquinone on Melanoderm™ skin model as controls in screening architecture for skin lightening actives and formulas

Cezary Skobowiat, O. V. Dueva‐Koganov, Chilton Crane, Cathal S. Mahon et autres

860 Evaluation of topical dermatologics containing L-ascorbic acid and its esters on Melanoderm™

O. V. Dueva‐Koganov, Chilton Crane, Trenton Oswald, Cezary Skobowiat et autres

EXPRESSION OF CONCERN: Melatonin and its derivatives counteract the ultraviolet B radiation‐induced damage in human and porcine skin ex vivo

Cezary Skobowiat, Anna A. Brożyna, Zorica Janjetović, Saowanee Jeayeng et autres

Abstract Melatonin and its derivatives ( N 1 ‐acetyl‐ N 2 ‐formyl‐5‐methoxykynurenine [ AFMK ] and N ‐acetyl serotonin [ NAS ]) have broad‐spectrum protective effects against photocarcinogenesis, including both direct and indirect antioxidative actions, regulation of apoptosis and DNA damage repair; …

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Effect of maternal high-fat diet on key components of the placental and hepatic endocannabinoid system

Kushal Gandhi, Cun Li, Nadezhda A. German, Cezary Skobowiat et autres

Maternal obesity in pregnancy has been linked to a spectrum of adverse developmental changes. Involvement of eCBs in obesity is well characterized. However, information regarding eCB physiology in obesity associated with pregnancy is sparse. This study evaluated fetomaternal hepatic, systemic, and placental …

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