New effects of caffeine on corticotropin‐releasing hormone (CRH)‐induced stress along the intrafollicular classical hypothalamic–pituitary–adrenal (HPA) axis (CRH‐R1/2, IP3‐R, ACTH, MC‐R2) and the neurogenic non‐HPA axis (substance P, p75NTRand TrkA) inex vivohuman male androgenetic scalp hair follicles
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Le résumé fourni par la source
Human hair is highly responsive to stress, and human scalp hair follicles (HFs) contain a peripheral neuroendocrine equivalent of the systemic hypothalamic–pituitary–adrenal (HPA) stress axis. Androgenetic alopecia (AGA) is supposed to be aggravated by stress. We used corticotropin‐releasing hormone (CRH), which triggers the HPA axis, to induce a stress response in human ex vivo male AGA HFs. Caffeine is known to reverse testosterone‐mediated hair growth inhibition in the same hair organ culture model. To investigate whether caffeine would antagonize CRH‐mediated stress in these HFs. HFs from balding vertex area scalp biopsies of men affected by AGA were incubated with CRH (10−7 mol L−1) with or without caffeine (0·001% or 0·005%). Compared to controls, CRH significantly enhanced the expression of catagen‐inducing transforming growth factor‐β2 (TGF‐β2) (P < 0·001), CRH receptors 1 and 2 (CRH‐R1/2) (P < 0·01), adrenocorticotropic hormone (ACTH) (P < 0·001) and melanocortin receptor 2 (MC‐R2) (P < 0·001), and additional stress‐associated parameters, substance P and p75 neurotrophin receptor (p75NTR). CRH inhibited matrix keratinocyte proliferation and expression of anagen‐promoting insulin‐like growth factor‐1 (IGF‐1) and the pro‐proliferative nerve growth factor receptor NGF‐tyrosine kinase receptor A (TrkA). Caffeine significantly counteracted all described stress effects and additionally enhanced inositol trisphosphate receptor (IP3‐R), for the first time detected in human HFs. These findings provide the first evidence in ex vivo human AGA HFs that the stress mediator CRH induces not only a complex intrafollicular HPA response, but also a non‐HPA‐related stress response. Moreover, we show that these effects can be effectively antagonized by caffeine. Thus, these data strongly support the hypothesis that stress can impair human hair physiology and induce hair loss, and that caffeine may effectively counteract stress‐induced hair damage and possibly prevent stress‐induced hair loss.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- New effects of caffeine on corticotropin‐releasing hormone (CRH)‐induced stress along the intrafollicular classical hypothalamic–pituitary–adrenal (HPA) axis (CRH‐R1/2, IP<sub>3</sub>‐R, ACTH, MC‐R2) and the neurogenic non‐HPA axis (substance P, p75<sup>NTR</sup>and TrkA) in<i>ex vivo</i>human male androgenetic scalp hair follicles
- Date Crossref
- 24/06/2020
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Johannes Kepler University of Linz pays non établi dans la noticeUniversité ou école supérieure
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University of Lübeck Department of Dermatology pays non établi dans la noticeUniversité ou école supérieure
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University of Alabama at Birmingham pays non établi dans la noticeUniversité ou école supérieure
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Birmingham VA Medical Center pays non établi dans la noticeÉtablissement de santé
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University of Miami Department of Dermatology & pays non établi dans la noticeUniversité ou école supérieure
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University of Manchester pays non établi dans la noticeUniversité ou école supérieure
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NIHR Manchester Biomedical Research Centre pays non établi dans la noticeStructure de recherche
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Department of Dermatology Kepler University Hospital Johannes Kepler University Linz Linz Austria pays non établi dans la noticeUniversité ou école supérieure
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VA Medical Center Birmingham AL 35294 USA pays non établi dans la noticeÉtablissement de santé
Johannes Kepler University of Linz, Department of Dermatology — University of Lübeck et University of Alabama at Birmingham, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.