Romana R. Gerner

Immunomodulatory metabolites define long-term gut microbiome recovery after allogeneic HCT and associate with improved survival and reduced relapse related mortality

Alix Schwarz, Tina Eismann, Tingting Zheng, Simon Holzinger et autres

ABSTRACT The intestinal microbiome influences immune recovery and long-term outcomes after allogeneic hematopoietic stem cell transplantation (allo-SCT). While reduced bacterial diversity and depletion of immunomodulatory microbial metabolites during peri-engraftment have been linked to acute graft-versus-host disease (aGvHD) and mortality, it remains unclear …

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DOP144 Escherichia coli shapes intestinal B-cell responses and influences susceptibility to Inflammatory Bowel Disease

S Adlkirchner, V Becker, Volker Betz, K Mühlschlegel et autres

Abstract Background Escherichia coli (Ec) is among the earliest commensals to colonize the neonatal gut and becomes enriched during IBD1,2, likely reflecting metabolic advantages during colitis. While these ecological shifts are well documented, how dysregulated mucosal immune responses to Ec influence inflammatory …

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The role of microbial metabolites in fecal microbiota transplantation in patients with acute gvhd of the gut

Alix Schwarz, Simon Holzinger, Peter Herhaus, Mareike Verbeek et autres

Abstract Acute graft-versus-host disease (aGvHD) remains a serious complication of allogeneic stem cell transplantation (alloSCT), most commonly affecting the skin and gastrointestinal tract. Non-responsiveness to steroids and ruxolitinib is associated with high morbidity and mortality, highlighting an urgent need for novel treatments. …

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Commensal Escherichia coli colonization triggers Peyer’s patch development

Romana R. Gerner, G. Walker, Suzi Klaus, Karine Melchior et autres

Abstract The gut microbiota plays a pivotal role in shaping mucosal immunity, yet the specific microbes contributing to lymphoid tissue development remain poorly defined. Here, we identify Escherichia coli , a pioneer commensal bacterium, as a key driver of naïve B cell …

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Uniting against enteric invaders: IgA meets its microbial ally

Sophia Adlkirchner, Romana R. Gerner

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Multidimensional differences of right- and left-sided colorectal cancer and their impact on targeted therapies

Marwa Abdel Hamid, Lorenz M. Pammer, Silvia Oberparleiter, Michael Günther et autres

Despite advances in metastatic colorectal cancer (mCRC) treatment, long-term survival remains poor, particularly in right-sided colorectal cancer (RCRC), which has a worse prognosis compared to left-sided CRC (LCRC). This disparity is driven by the complex biological diversity of these malignancies. RCRC and …

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Loss of Microbiota-Derived Metabolites Is Associated with Mucosal-Barrier-Injury Bloodstream Infection in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Sophia Göldel, Tingting Zheng, Tina Eismann, Melanie Tiefgraber et autres

Background Conditioning for allogeneic hematologic stem cell transplantation (allo-SCT) is associated with mucosal barrier injury (MBI) and neutropenia. This results in a high risk of infection and, consequently, in higher mortality, with more than 40% of allo-SCT patients suffering from bloodstream infections …

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CCL28 modulates neutrophil responses during infection with mucosal pathogens

G. Walker, Araceli Pérez-López, Steven Silva, Michael H. Lee et autres

The chemokine CCL28 is highly expressed in mucosal tissues, but its role during infection is not well understood. Here, we show that CCL28 promotes neutrophil accumulation in the gut of mice infected with Salmonella and in the lung of mice infected with …

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Author response: CCL28 modulates neutrophil responses during infection with mucosal pathogens

G. Walker, Araceli Pérez-López, Steven Silva, Michael H. Lee et autres

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IL-22-dependent responses and their role during Citrobacter rodentium infection

Karine Melchior, Romana R. Gerner, Suzana Hossain, Sean‐Paul Nuccio et autres

ABSTRACT The mouse pathogen Citrobacter rodentium is utilized as a model organism for studying infections caused by the human pathogens enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) and to elucidate mechanisms of mucosal immunity. In response to C. rodentium infection, …

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Lipocalin-2 expression identifies an intestinal regulatory neutrophil population during acute graft-versus-host disease

Marie Czech, Sophia Schneider, Nina Peltokangas, Nadia El Khawanky et autres

Acute graft-versus-host disease (aGVHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT), for which therapeutic options are limited. Strategies to promote intestinal tissue tolerance during aGVHD may improve patient outcomes. Using single-cell RNA sequencing, we identified a lipocalin-2 (LCN2)-expressing neutrophil …

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Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice

Adriana Vasquez Ayala, Chia-Yun Hsu, Renee Oles, Kazuhiko Matsuo et autres

Type I interferons (IFNs) exert a broad range of biological effects important in coordinating immune responses, which have classically been studied in the context of pathogen clearance. Yet, whether immunomodulatory bacteria operate through IFN pathways to support intestinal immune tolerance remains elusive. …

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