Airy Sanjeev

Prediction of structural variation

Yogesh Kalakoti, Airy Sanjeev, Björn Wallner

Proteins are dynamic molecules that transition between conformational states to perform their functions, and characterizing the protein ensemble is important for understanding biology and therapeutic applications. While recent breakthroughs in machine learning have enabled the prediction of high-quality static models of individual …

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Artificial Intelligence Predicts Sensitivity of EGFR Novel Mutations to Tyrosine Kinase Inhibitors

Raunak Kumar, Airy Sanjeev, Isha Shinde, Asif Khan et autres

*Correspondence author: (e-mail: pratikchandrani@gmail.com).

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Isoliquiritigenin: a potential drug candidate for the management of erectile dysfunction

Queen Saikia, Kamal Adhikari, Airy Sanjeev, Ajit Hazarika et autres

OBJECTIVE: This study aimed to assess the erectogenic properties of isoliquiritigenin taking sildenafil (SDF) as the standard. METHODS: The binding affinity of isoliquiritigenin (ISL) with the erectile marker proteins (endothelial nitric oxide synthase [eNOS] and enzyme phosphodiesterase type 5 [PDE5]) was investigated …

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RET Alterations Differentiate Molecular Profile of Medullary Thyroid Cancer

Kumar Prabhash, Elveera Saldanha, Vijay Patil, Munita Meenu Bal et autres

PURPOSE Medullary thyroid cancer (MTC) is a rare cancer originating from parafollicular C cells of the thyroid gland. Therapeutically relevant alterations in MTC are predominantly reported in RET oncogene, and lower-frequency alterations are reported in KRAS and BRAF . Nevertheless, there is …

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Computational investigation on the effect of Oleuropein aglycone on the α-synuclein aggregation

Priyanka Borah, Airy Sanjeev, Venkata Satish Kumar Mattaparthi

Parkinson’s disease (PD) is considered to be the second most common progressive neurodegenerative brain disorder after Alzheimer’s disease, which is caused by misfolding and aggregation of Alpha-synuclein (α-synuclein). It is characterized by distinct aggregated fibrillary form of α-synuclein known as the Lewy …

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CCDC 1523576: Experimental Crystal Structure Determination

Mitu Sharma, Mani Ganeshpandian, Airy Sanjeev, Tamilarasan Ajaykamal et autres

CCDC 1523577: Experimental Crystal Structure Determination

Mitu Sharma, Mani Ganeshpandian, Airy Sanjeev, Tamilarasan Ajaykamal et autres

Bis- and mixed-ligand copper(II) complexes of nalidixic acid the antibacterial drug: Mode of nalidixate coordination determines DNA binding and cleavage and cytotoxicity

Mitu Sharma, Mani Ganeshpandian, Airy Sanjeev, Tamilarasan Ajaykamal et autres

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Computational Study on the Role of γ-Synuclein in Inhibiting the α-Synuclein Aggregation

Airy Sanjeev, Venkata Satish Kumar Mattaparthi

BACKGROUND: α-Synuclein (αS) is the precursor protein present in Lewy Bodies that helps in the formation of highly ordered amyloid fibrils that is associated with the occurrence of Parkinson's disease, a neuro-degenerative disorder. Many reports have now been focused on finding the …

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Nucleic-Acid Structure Database

Airy Sanjeev, Venkata Satish Kumar Mattaparthi, Sandeep Kaushik

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Dimerization of C-terminal Truncations of α-synuclein and its Effect on the Aggregation Propensity: A Potential of Mean Force Study

Airy Sanjeev, Venkata Satish Kumar Mattaparthi

Background: The occurrence of Parkinson’s Disease (PD) is associated with the deposition of proteinaceous aggregates formed by the self-assembly of α-synuclein protein. The pathogenesis of PD has been reported to be linked with the α-synuclein gene. However, the presence of missense mutations: …

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Effect of C-terminal truncations on the aggregation propensity of A53E, a familial mutant of α-Synuclein: An Insilico Study

Airy Sanjeev, Venkata Satish Kumar Mattaparthi

α-Synuclein, an intrinsically disordered protein, is well known for its role on the onset of Parkinson’s Disease (PD), a neurodegenerative disorder. In α-synuclein, several mutations have been known to cause genetic forms of PD. Recently a new familial mutant, A53E of α-synuclein …

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