Accès ouvert
2026
preprint
OpenAlex
Sara Macias Palacio, Nicole G. Rummel, James Campbell, D. Allan Butterfield et autres
Abstract Glioblastoma (GBM) is the most aggressive primary brain tumor in adults. Cognitive impairment is a common sequela in glioblastoma survivors, yet the underlying mechanisms remain poorly understood. Extracellular vesicles (EVs) derived from glioblastoma are established mediators of intercellular signaling within the …
us
(code pays fourni par la source)
2025
article
OpenAlex
Sarah Brandão Palácio, Nicole G. Rummel, James N. Campbell, Allan Butterfield et autres
us
(code pays fourni par la source)
2024
article
OpenAlex
Sarah Brandão Palácio, Nicole G. Rummel, James N. Campbell, David Allan Butterfield et autres
us
(code pays fourni par la source)
2021
conference-abstract
OpenAlex
Jacqueline R. Rivas, Sara Samir Alhakeem, Yang Liu, Joseph M. Eckenrode et autres
Abstract T-cell-based immunotherapy revolutionized the treatment of immune suppressive cancers. Blocking T cell inhibitory receptors such as programmed death 1 (PD1) or their ligands (like PD-L1) enhances antitumor T cell responses. However, many cancers employ multiple methods of immune suppression, including the …
us
(code pays fourni par la source)
2020
conference-abstract
OpenAlex
Subbarao Bondada, James P. Collard, Mary Kathryn McKenna, Sunil K. Noothi et autres
Abstract Chronic Lymphocytic Leukemia (CLL), the most prevalent adult leukemia, is characterized by the clonal expansion of CD5+ CD19+ B cells within lymphoid organs and accumulation of quiescent cells in the blood. Eμ-Tcl1 transgenic mice expressing the Tcl1 oncogene in a B …
us
(code pays fourni par la source)
2018
conference-abstract
OpenAlex
Jacqueline R. Rivas, Sara Samir Alhakeem, Joseph M. Eckenrode, Yinan Zhang et autres
Abstract B cell Chronic Lymphocytic Leukemia (CLL), the most common leukemia in the western world, is characterized by an accumulation of abnormal B cells in the blood and lymphoid organs. Broad immunosuppression is a serious complication for these patients, with infections and …
us
(code pays fourni par la source)
2016
article
OpenAlex
Sara Samir Alhakeem, Mary Kathryn McKenna, Sunil K Nooti, Karine Z. Oben et autres
Abstract The most common human leukemia is B-cell chronic lymphocytic leukemia (B-CLL), which is characterized by a progressive accumulation of abnormal B-lymphocytes in blood, bone marrow and secondary lymphoid organs. Typically disease progression is slow, but as the number of leukemic cells …
us
(code pays fourni par la source)
2016
conference-abstract
OpenAlex
Mary Kathryn McKenna, Sunil K Nooti, Sara Samir Alhakeem, Beth W. Gachuki et autres
Abstract Chronic Lymphocytic Leukemia (CLL), the most common adult leukemia in the western world, is characterized by accumulation of clonally expanded CD5 + CD19 + B lymphocytes in blood and secondary lymphoid organs with impaired apoptotic mechanisms. Prostate apoptosis response-4 (Par-4) is …
us
(code pays fourni par la source)
2016
conference-abstract
OpenAlex
Karine Z. Oben, Beth W. Gachuki, Shailaja Akunuru, J. Anthony Brandon et autres
Abstract Myelodysplastic syndrome (MDS) affects bone marrow production of white blood cells and erythrocytes. At least 40% of MDS patients who go into remission after treatment eventually progress to acute myelogenous leukemia (AML) which is very difficult to treat. Hence, there is …
us
(code pays fourni par la source)
2015
article
OpenAlex
Sunil K Nooti, Mary Kathryn McKenna, Frank W. Frissora, Beth W. Gachuki et autres
Abstract Chronic Lymphocytic Leukemia (CLL) is characterized by accumulation of clonally expanded population of CD5+ CD19+ B lymphocytes in peripheral blood and secondary lymphoid organs, with a majority of circulating cells in a non-dividing resting stage. However CLL is no longer considered …
us
(code pays fourni par la source)
2015
conference-abstract
OpenAlex
Mary Kathryn McKenna, Sunil K Nooti, Sara Samir Alhakeem, Beth W. Gachuki et autres
Abstract B cell malignancies such as non-Hodgkin’s Lymphoma have a probability of affecting 1 in 43 people in the United States, contributing to 7% of all cancer related deaths. The most aggressive forms of non-Hodgkin’s Lymphomas, which include Chronic Lymphocytic Leukemia (CLL), …
us
(code pays fourni par la source)
2015
conference-abstract
OpenAlex
Sara Samir Alhakeem, Mary Kathryn McKenna, Beth W. Gachuki, Chi Wang et autres
Abstract The most common human leukemia is B-cell chronic lymphocytic leukemia (B-CLL), which can have immunosuppressive effects. CLL cells share multiple phenotypic markers with B-1 B cells such as their surface expression of CD5. This study identifies some functional similarities between B-1 …
us
(code pays fourni par la source)