Muhui Zeng

Cross‐Sectional and Longitudinal Association Between Biological Aging Acceleration and the Risk of Osteoarthritis: A Cohort Study From UK Biobank

Sisi Liu, Weishu Wang, Chengxu Li, Yuxin Lai et autres

OBJECTIVE: To evaluate the relationship between biological ages and the prevalence and incidence of osteoarthritis (OA). METHODS: 332 261 participants from UK Biobank were analyzed. Biological aging was measured using phenotypic age (PhenoAge) and Klemera-Doubal (KDMAge). KDMAge was derived from nine clinical …

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Tristetraprolin protects against osteoarthritis by restraining chondrocyte mitochondrial DNA release through post-transcriptional regulation

H Huang, Jianmao Chen, Yingshi Zhan, Song Xue et autres

Background and objective: Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation and chronic inflammation. Tristetraprolin (TTP) is an RNA-binding protein with anti-inflammatory properties, but its role in OA remains unclear. This study aimed to investigate the function of TTP …

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Association of accelerometer-measured physical activity patterns with cardiovascular diseases and mortality in people with osteoarthritis

Tianxiang Fan, Qiyu Xie, Jiawei Chen, Muhui Zeng et autres

OBJECTIVE: To explore the associations between accelerometer-measured physical activity patterns and cardiovascular diseases (CVD), CVD-cause mortality and all-cause mortality in people with osteoarthritis (OA). METHODS: OA participants from the UK biobank with ≥36 h of accelerometer data, collected over one-week, were analysed. …

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Associations of physical activity and sedentary behaviors with mortality: An observational analysis and Mendelian randomization study

Menglin Han, Yudun Qu, Muhui Zeng, Ziqi Gu et autres

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Interaction of alcohol consumption and genetic variants in alcohol metabolism on all-cause and disease-specific mortality: a cohort study

Guangfeng Ruan, Zhaohua Zhu, Han Cen, Yuanyuan Wang et autres

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Associations between metabolic heterogeneity of obesity and osteoarthritis: A prospective cohort study

Hao Yang, Muhui Zeng, Jiawei Chen, Changhai Ding et autres

Abstract Background Previous studies have shown that obesity accelerates the development of osteoarthritis (OA). However, obesity is metabolically heterogeneous. The association between metabolic heterogeneity of obesity and incident OA remains unclear. Methods A total of 381,036 participants from the UK Biobank (UKBB) …

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Associations of healthy lifestyle and genetic susceptibility with risks of osteoarthritis: a prospective cohort study

Shibo Chen, Yujie Zhang, Tianxiang Fan, Muhui Zeng et autres

OBJECTIVES: To detect the associations of a healthy lifestyle and genetic susceptibility with incident OA in the UK Biobank study. METHODS: We included 314 729 participants from UK Biobank. Five modifiable lifestyle factors including weight management, diet, physical activity, sleep behaviour and …

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POS0406 ASSOCIATIONS BETWEEN THE TRIGLYCERIDE-GLUCOSE INDEX AND THE RISKS OF INCIDENT DIABETES AND CARDIOVASCULAR DISEASES IN INDIVIDUALS WITH OSTEOARTHRITIS: A LARGE-SCALE PROSPECTIVE COHORT STUDY

Wei Wu, Hua Zhang, Muhui Zeng, Junya Jia et autres

Background: The triglyceride-glucose (TyG) index is an emerging surrogate indicator of insulin resistance (IR). Although several studies have reported the association between TyG index and increased risks of diabetes and cardiovascular disease (CVD) in general population, its relationship with diabetes and CVD …

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ASSOCIATIONS AND PREDICTIVE PERFORMANCE OF NINE ADIPOSITY-RELATED MARKERS WITH INCIDENT OSTEOARTHRITIS: FINDINGS FROM A PROSPECTIVE COHORT STUDY

Hao Zhang, Hao Yang, Muhui Zeng, Xiaomeng Wang et autres

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ASSOCIATION OF COMBINED EXPOSURE TO AMBIENT AIR POLLUTANTS, GENETIC RISK, AND INCIDENT OSTEOARTHRITIS: A PROSPECTIVE COHORT STUDY

Yufang Xiong, Shifeng Wen, Muhui Zeng, Hao Yang et autres

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Associations of metabolic status with all-cause mortality among individuals with osteoarthritis: A prospective cohort study

Hao Yang, Muhui Zeng, Tianxiang Fan, Haowei Chen et autres

Background: Individuals with osteoarthritis (OA) often experience significant changes in their metabolic status and have a higher risk of mortality compared to the general population. However, no study has quantified the metabolic status of OA patients. Moreover, the association between metabolic status …

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Quantitative analysis of effectiveness and associated factors of exercise on symptoms in osteoarthritis: a pharmacodynamic model-based meta-analysis

Shun Han, Ting Li, Ying Cao, Zewei Li et autres

OBJECTIVE: This study aims to evaluate the time point and magnitude of peak effectiveness of exercise and the effects of various exercise modalities for osteoarthritis (OA) symptoms and to identify factors that significantly affect the effectiveness of exercise. DESIGN: Pharmacodynamic model-based meta-analysis …

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