Cross‐Sectional and Longitudinal Association Between Biological Aging Acceleration and the Risk of Osteoarthritis: A Cohort Study From UK Biobank
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Le résumé fourni par la source
OBJECTIVE: To evaluate the relationship between biological ages and the prevalence and incidence of osteoarthritis (OA). METHODS: 332 261 participants from UK Biobank were analyzed. Biological aging was measured using phenotypic age (PhenoAge) and Klemera-Doubal (KDMAge). KDMAge was derived from nine clinical biomarkers to gauge system integrity decline, while PhenoAge was computed from chronological age and nine clinical biomarkers to gauge mortality risk. Biological aging accelerations were computed as residuals from regressing KDMAge and PhenoAge against chronological age. The associations between biological aging and prevalence and incidence of OA were analyzed using logistic and Cox regression models. RESULTS: At baseline, 55.4% of included individuals had younger PhenoAge aging acceleration. In cross-sectional analyses, individuals with accelerated aging had higher odds of OA compared to those with non-accelerated aging (odds ratios [OR]: 1.12 [95% CI: 1.09-1.14] for PhenoAge acceleration and 1.05 [1.03-1.08] for KDMAge acceleration). In the longitudinal analyses, increased PhenoAge acceleration was associated with a higher risk of incident OA (hazard ratios [HR]: 1.12 [1.10-1.15]). However, the association between KDMAge acceleration and the incidence of OA was not statistically significant (HR: 0.99 [0.97-1.01]). Accelerated biological aging showed a more pronounced association with OA among individuals > 60 years. No additive or multiplicative interactions were found between OA polygenic risk score (PRS) and biological aging. CONCLUSION: Advanced biological aging may increase the risk of OA, independent of OA genetic risk, particularly in individuals aged over 60 years. The two biological aging indicators hold potential as novel composite clinical biomarkers, directing prevention and intervention strategies for high-risk populations for OA.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Cross‐Sectional and Longitudinal Association Between Biological Aging Acceleration and the Risk of Osteoarthritis: A Cohort Study From <scp>UK</scp> Biobank
- Date Crossref
- 01/09/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Zhujiang Hospital pays non établi dans la noticeÉtablissement de santé
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Southern Medical University Clinical Research Centre Zhujiang Hospital pays non établi dans la noticeUniversité ou école supérieure
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First Affiliated Hospital of Jinan University pays non établi dans la noticeÉtablissement de santé
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81th Hospital of PLA pays non établi dans la noticeÉtablissement de santé
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University of Bristol Population Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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General Hospital of Guangzhou Military Command pays non établi dans la noticeÉtablissement de santé
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Hong Kong Polytechnic University pays non établi dans la noticeUniversité ou école supérieure
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Chinese University of Hong Kong pays non établi dans la noticeUniversité ou école supérieure
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Guangzhou First People's Hospital pays non établi dans la noticeÉtablissement de santé
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Guangzhou Medical University pays non établi dans la noticeUniversité ou école supérieure
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Royal North Shore Hospital pays non établi dans la noticeÉtablissement de santé
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Institute for Musculoskeletal Health pays non établi dans la noticeStructure de recherche
Zhujiang Hospital, Clinical Research Centre Zhujiang Hospital — Southern Medical University et First Affiliated Hospital of Jinan University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.