Shalini Bhalla

Lymph Node Yield in Extended Lymph Node Dissection for Gallbladder Carcinoma: Insights from a High-Prevalence Area

Abhinav Arun Sonkar, Parijat Suryavanshi, Akshay Anand, Awanish Kumar et autres

Clinicopathological and Prognostic Implications of Circulating MicroRNA-429 in Breast Cancer Patients

Shivangini Sharma, Taniya Suryavanshi, Preeti Agarwal, Alok Singh et autres

BACKGROUND/AIMS: MicroRNA-429 (miR-429), a member of the miR-200 family, has been implicated in epithelial-mesenchymal transition and tumor progression, yet its clinicopathological significance in breast cancer remains unclear. This study aimed to evaluate serum miR-429 expression in treatment-naïve breast cancer patients and correlate …

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Development and evaluation of objective structured practical examination (OSPE) as a formative assessment tool for clinical microbiology residents

Parul Jain, Vimala Venkatesh, Shalini Bhalla, Sandeep Bhattacharya et autres

BACKGROUND: The Objective Structured Practical Examination (OSPE) has been widely used as an effective formative assessment tool in various branches of Medicine; however, its application in Microbiology residency training remains limited. Additionally, clearly defined educational milestones are lacking in this discipline. This …

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Single-Nucleotide Polymorphisms rs2253310 and rs4946936 in the forkhead box O3 Gene and Their Correlation with Prognosis in Glioblastoma

Shamanaz, Shivanjali Raghuvanshi, Atin Singhai, Shalini Bhalla et autres

BACKGROUND: Glioblastoma is the most aggressive primary brain tumor characterized by poor prognosis and complex molecular alterations. Forkhead box O3 (FOXO3), a transcription factor involved in apoptosis, oxidative stress, and cell cycle regulation, has been implicated in cancer biology. This study aimed …

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Adenomyoepithelioma breast: A known entity yet a diagnostic challenge on cytology

Shalini Bhalla, Swati Mishra, Akansha Agarwal, Prateek Mehrotra

Background: Adenomyoepithelioma (AME) is an uncommon benign breast neoplasm characterized by proliferation of myoepithelial cells surrounding small epithelium-lined spaces. Diagnosis on Fine needle aspiration (FNA) are quoted in handful case reports as well as short case series. Patients are usually postmenopausal females …

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Histopathological Spectrum of Lesions of the Nasal Cavity and Paranasal Sinuses: A Five-year Cross-sectional Study from a Tertiary Care Centre, Lucknow, India

Ch Pawan Pratap Singh, Malti Kumari Maurya, Manoj Kumar Yadav, Mala Sagar et autres

=[Introduction: Polyps or masses arising in the sinonasal area can disturb local anatomy and physiology with similar kinds of symptoms, including sneezing, epistaxis, respiratory obstruction and destruction of local structures. These lesions can be categorised as non-neoplastic or neoplastic. Advanced radiological techniques …

PIK3CA Polymorphisms in Cervical Cancer: Differential Impact of rs6443624 and rs141178472

Harshi Srivastava, Shivanjali Raghuvanshi, Shalini Bhalla, Snehkiran Raghuvanshi et autres

BACKGROUND: Cervical cancer remains a major cause of mortality in low- and middle-income settings. We assessed whether two PIK3CA single-nucleotide polymorphisms (SNPs) rs6443624 (A/C) and rs141178472 (C/T) are associated with disease risk, clinicopathological features, and survival. MATERIALS AND METHODS: In a prospective …

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Immunoexpression and Activation of STAT1 and STAT3 in Invasive Breast Carcinoma No Special Type: Implications for Triple-Negative Breast Cancer and BRCA1 Status

Preeti Agarwal, Ann Thomas, Babli Gupta, Shalini Bhalla et autres

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The New WHO Lung Cytopathology Reporting System in Practice: Diagnostic Performance and Risk of Malignancy in a Tertiary Care Setting

Shalini Bhalla, Mahak Lamba, Mamta Dwivedi, Shivanjali Raghuvanshi et autres

BACKGROUND: Respiratory cytology plays a vital role in the early diagnosis of pulmonary diseases, particularly lung cancer, which remains a leading cause of cancer-related mortality worldwide. To enhance standardization and reduce inter-observer variability in lung cytology reporting, the World Health Organization (WHO), …

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CD68+ Microglial Landscape in Optic Pathway of Donated Cadavers: Correlation with Demographics and Comorbidities

Chetana Sharma, Anita Rani, Archana Rani, Shalini Bhalla et autres

Introduction: Microglia, is the resident immune cell of the central nervous system (CNS), playing a key role in maintaining homeostasis and responding to injury. This study investigates the spatial distribution of CD68+ microglia within the human optic pathway, examining the influence of …

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An Integrative Analysis of O6-Methylguanine-DNA Methyltransferase (MGMT) Methylation and the Single-Nucleotide Polymorphism (SNP) rs1625649 Reveals Distinct Survival Patterns in Glioblastoma: A Retrospective Study

Krachi Agarwal, Shivanjali Raghuvanshi, Shalini Bhalla, Alok Singh et autres

Background O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation is an established predictive and prognostic biomarker in glioblastoma (GBM). However, the influence of MGMT promoter single-nucleotide polymorphisms (SNPs), particularly rs1625649, on gene expression and patient outcomes remains unclear. This study evaluated the prognostic impact of …

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Maturation (Fibrosis) Pattern of Vasculature on Histology Defines Directional Progression in Nasopharyngeal Angiofibroma: Observational Study

Shalini Bhalla, Rohit Verma, Anupam Mishra

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