Ronny Myhre

Genetic characterization of preschool wheeze phenotypes

Kasper Fischer‐Rasmussen, Raquel Granell, Anders Eliasen, Eskil Kreiner et autres

BACKGROUND: Preschool wheeze is a heterogenous and poorly understood clinical syndrome. As a result, current treatments are insufficient, and prevention is not possible. OBJECTIVE: We sought to increase understanding of the genetic susceptibility and underlying disease mechanisms of wheeze phenotypes in early …

dk, gb, se, fr, nl, es, de, us, no, au, ca (code pays fourni par la source)

Do genetic variants of the Y chromosome affect mortality from COVID-19

Ole Bernt Lenning, Ronny Myhre, May Sissel Vadla, Roald Omdal et autres

AIMS: During the early stages of the COVID-19 pandemic, significant differences in mortality patterns emerged based on sex and geographical regions. While we were studying on the heredity of variants of the Y chromosome, we observed that regional variations in mortality rates …

no, es (code pays fourni par la source)

Associations between common genetic variants and income provide insights about the socio-economic health gradient

Hyeokmoon Kweon, Casper A.P. Burik, Yuchen Ning, Rafael Ahlskog et autres

We conducted a genome-wide association study on income among individuals of European descent (N = 668,288) to investigate the relationship between socio-economic status and health disparities. We identified 162 genomic loci associated with a common genetic factor underlying various income measures, all …

nl, se, gb, ee, no, hr, us, ch, fi, de, dk, au, tw, kr (code pays fourni par la source)

Associations between common genetic variants and income provide insights about the socio-economic health gradient

Hyeokmoon Kweon, Casper A.P. Burik, Yuchen Ning, Rafael Ahlskog et autres

Associations between common genetic variants and income provide insights about the socioeconomic health gradient

Philipp Koellinger, Hyeokmoon Kweon, Casper A.P. Burik, Yuchen Ning et autres

nl, se, gb, ee, no, us, hr, ch, fi, de, dk, au (code pays fourni par la source)

Associations between common genetic variants and income provide insights about the socioeconomic health gradient

Hyeokmoon Kweon, Casper A.P. Burik, Yuchen Ning, Rafael Ahlskog et autres

Abstract We conducted a genome-wide association study (GWAS) on income among individuals of European descent and leveraged the results to investigate the socio-economic health gradient ( N =668,288). We found 162 genomic loci associated with a common genetic factor underlying various income …

nl, se, gb, ee, no, hr, us, ch, fi, de, dk, au, tw (code pays fourni par la source)

A second update on mapping the human genetic architecture of COVID-19

Shea J. Andrews, Mattia Cordioli, Christine Stevens, Mark J. Daly et autres

Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development 1 , 2 . Here we present a second updated genome-wide association study (GWAS) …

us, fi, pl, my, ch, gb, Burkina Faso, ca, pr, it, in, Égypte, es, nl, Afrique du Sud, cl, hu, br, fr, be, mx, au, de, jp, py (code pays fourni par la source)

Detailed stratified GWAS analysis for severe COVID-19 in four European populations

Frauke Degenhardt, David Ellinghaus, Simonas Juzėnas, Jon Lerga-Jaso et autres

Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a …

dk, lt, es, de, us, ca, no, fr, it, nl, fi, at, li (code pays fourni par la source)

Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

Aysu Okbay, Yeda Wu, Nancy Wang, Hariharan Jayashankar et autres

We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12-16% of EA variance and contributes …

nl, au, us, se, gb, dk, is, de, it, fi, at, gr, ee, ch (code pays fourni par la source)

A Phylogenetic Approach to the Uneven Global Distribution of the COVID-19 Pandemic

Ole Bernt Lenning, Ronny Myhre, May Sissel Vadla, Geir Sverre Braut

A possible role of Y chromosomal haplogroups in COVID-19 mortality is discussed without claiming causality. The mortality of COVID-19 seems unequally distributed in different populations and statistically significant regional covariation is presented between COVID-19 mortality and the haplogroup Y-R1b. Y-R1b is suggested …

no (code pays fourni par la source)

Detailed stratified GWAS analysis for severe COVID-19 in four European populations

Frauke Degenhardt, David Ellinghaus, Simonas Juzėnas, Jon Lerga-Jaso et autres

ABSTRACT Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a …

dk, lt, es, de, us, no, it, fi, at, li (code pays fourni par la source)

Mapping the human genetic architecture of COVID-19

Mari Niemi, Juha Karjalainen, Rachel G. Liao, Benjamin M. Neale et autres

Abstract The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19 1,2 , host genetics may …

fi, us, es, de, it, gb, nl, ca, kr, jp, ae, fr, au, pl, in, be, qa, dk, cl, pr, mx (code pays fourni par la source)