Peiyi Zhu

miR-181a targets PTEN to mediate the neuronal injury caused by oxygen-glucose deprivation and reoxygenation

Shengnan Li, Peiyi Zhu, Yajun Wang, Shaoting Huang et autres

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Polymorphisms of Calgranulin Genes and Ischemic Stroke in a Chinese Population

Linfa Chen, Xinglan Chen, Yajun Wang, Shengnan Li et autres

Background: The S100/calgranulin gene appears to modulate neuroinflammation following cerebral ischemia and could be a valuable biomarker for stroke prognosis, according to growing research. This study aimed at evaluating the correlation between calgranulin gene variants and susceptibility to ischemic stroke (IS) in …

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Troglitazone inhibits hepatic oval cell proliferation by inducing cell cycle arrest through Hippo/YAP pathway regulation

Yifeng He, Haijian Li, HE Yun-he, Caijie Lu et autres

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microRNA‐186 alleviates oxygen‐glucose deprivation/reoxygenation‐induced injury by directly targeting hypoxia‐inducible factor‐1α

Shengnan Li, Yajun Wang, Mengxu Wang, Linfa Chen et autres

Previous studies have suggested that microRNA-186 (miR-186) can be induced under hypoxic conditions, and is associated with apoptosis. This study was undertaken to explore the exact role of this microRNA (miRNA) in the apoptotic death of neurons during cerebral ischemic/reperfusion (I/R) injury. …

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Identification of Circular RNA hsa_circ_0001599 as a Novel Biomarker for Large-Artery Atherosclerotic Stroke

Shengnan Li, Weidong Hu, Fu Deng, Peiyi Zhu et autres

Circular RNAs (circRNAs) are a recently discovered noncoding RNA isoform capable of regulating neurological disease incidence. The present study was designed to characterize the circRNA expression profiles present in large-artery atherosclerosis (LAA)-type acute ischemic stroke patients and to detect biomarkers suitable for …

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Genetic Variants of lncRNA GAS5 Contribute to Susceptibility of Ischemic Stroke among Southern Chinese Population

Fu Deng, Peiyi Zhu, Chaoxiong Liao, Shengnan Li et autres

Emerging evidence suggests that the long noncoding RNA (lncRNA) growth arrest special 5 (GAS5) plays crucial roles in the pathogenesis of ischemic stroke (IS). The current research is aimed at assessing the correlation between two functional GAS5 variants (rs145204276 and rs55829688) and …

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Association of miR-155 and Angiotensin Receptor Type 1 Polymorphisms with the Risk of Ischemic Stroke in a Chinese Population

You Li, Yaoqun Peng, Shaoyu Yao, Linfa Chen et autres

There is increasing evidence suggesting that dysregulation of miR-155 and its target angiotensin receptor type 1 (AT1R) are linked to the incidence of ischemic stroke (IS), but the underlying mechanisms remain to be clarified. In this study, we therefore sought to investigate …

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Genetic variants of ADAMTS7 confer risk for ischaemic stroke in the Chinese population

Linfa Chen, Weidong Hu, Shengnan Li, Shaoyu Yao et autres

conferred a lower risk of developing large-artery atherosclerosis stroke subtype. Also, the mutated rs3825807 G allele, as well as the mutated rs11634042 T allele of ADAMTS7, are linked to a significant reduction of ADAMTS7 in patients with IS. Our findings confirm the …

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