David F. Dinges

Transient gray matter decline during antarctic isolation: Roles of sleep, exercise, and cognition

David R. Roalf, Mathias Basner, Joanne C. Beer, Russell T. Shinohara et autres

Astronauts face significant stress in space, and understanding its neurobiological basis is key to assessing risk and resilience. Analogue environments, like the Antarctic Concordia Station, replicate isolated, confined, and extreme (ICE) conditions. This study assessed brain structure changes in 25 crewmembers who …

us, de, nz, fr, au (code pays fourni par la source)

Morning resting hypothalamus-dorsal striatum connectivity predicts individual differences in diurnal sleepiness accumulation

Tianxin Mao, Bowen Guo, Peng Quan, Yao Deng et autres

While the significance of obtaining restful sleep at night and maintaining daytime alertness is well recognized for human performance and overall well-being, substantial variations exist in the development of sleepiness during diurnal waking periods. Despite the established roles of the hypothalamus and …

cn, us (code pays fourni par la source)

Locus coeruleus microstructural integrity is associated with vigilance vulnerability to sleep deprivation

Peng Quan, Tianxin Mao, Xiaocui Zhang, Ruosi Wang et autres

Insufficient sleep compromises cognitive performance, diminishes vigilance, and disrupts daily functioning in hundreds of millions of people worldwide. Despite extensive research revealing significant variability in vigilance vulnerability to sleep deprivation, the underlying mechanisms of these individual differences remain elusive. Locus coeruleus (LC) …

cn, us (code pays fourni par la source)

Objective alertness, rather than sleep duration, is associated with burnout and depression: A national survey of Japanese physicians

Hiroo Wada, Mathias Basner, Makayla Cordoza, David F. Dinges et autres

Approximately 40% of Japanese physicians report working more than 960 hr of overtime annually, with 10% exceeding 1860 hr. To protect their health, annual overtime limits went into effect in 2024. The objective of this study was to investigate associations of self-reported …

jp, us (code pays fourni par la source)

Biomathematical modeling of fatigue due to sleep inertia

Mark McCauley, Peter McCauley, Leonid Kalachev, Samantha M. Riedy et autres

us, au (code pays fourni par la source)

0141 Nighttime Napping Dampens Daily Peak of Sleepiness in Simulated Night Shift Schedules with Restricted Daytime Sleep

Rachael Muck, Christopher Jones, Mathias Basner, David F. Dinges et autres

Abstract Introduction Night shift workers experience increased sleepiness during the night due to increasing homeostatic sleep drive and reduced circadian wake drive, and because their daytime sleep is typically restricted. Nighttime napping is a countermeasure to sleepiness, but the effectiveness of different …

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The dynamics of neurobehavioral impairment and recovery sleep: improved biomathematical modeling for fatigue risk management in operational settings

Mark McCauley, Peter McCauley, Leonid Kalachev, Siobhan Banks et autres

Adequate sleep is essential for maintaining health, safety, and neurobehavioral functioning in 24/7 operational settings. Loss of sleep causes fatigue, which results in neurobehavioral impairment. Neurobehavioral impairment builds up disproportionately under conditions of total sleep deprivation compared to sustained sleep restriction; and …

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The dynamic responses of mood and sleep physiology to chronic sleep restriction and subsequent recovery sleep

Christopher Jones, Olivia Larson, Mathias Basner, David F. Dinges

Healthy sleep of sufficient duration preserves mood and disturbed sleep is a risk factor for a range of psychiatric disorders. As adults commonly experience chronic sleep restriction (SR), an enhanced understanding of the dynamic relationship between sleep and mood is needed, including …

us (code pays fourni par la source)

Associations of sleep with psychological health and alertness: a national survey of Japanese physician duty hours

Hideki Wada, Mathias Basner, Makayla Cordoza, David F. Dinges et autres

jp, us (code pays fourni par la source)

Long‐term influence of sleep/wake history on the dynamic neurobehavioural response to sustained sleep restriction

Siobhan Banks, Christopher Jones, Mark McCauley, Jillian Dorrian et autres

Chronic sleep restriction, common in today's 24/7 society, causes cumulative neurobehavioural impairment, but the dynamics of the build-up and dissipation of this impairment have not been fully elucidated. We addressed this knowledge gap in a laboratory study involving two, 5-day periods of …

au, us (code pays fourni par la source)

Sleep deprivation attenuates neural responses to outcomes from risky decision‐making

Tianxin Mao, Zhuo Fang, Ya Chai, Yao Deng et autres

Sleep loss impacts a broad range of brain and cognitive functions. However, how sleep deprivation affects risky decision-making remains inconclusive. This study used functional MRI to examine the impact of one night of total sleep deprivation (TSD) on risky decision-making behavior and …

cn, us, ca (code pays fourni par la source)

Mediation Analysis with Random Distribution as Mediator with an Application to iCOMPARE Trial

Jingru Zhang, Mathias Basner, Christopher Jones, David F. Dinges et autres

us (code pays fourni par la source)