Locus coeruleus microstructural integrity is associated with vigilance vulnerability to sleep deprivation
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Le résumé fourni par la source
Insufficient sleep compromises cognitive performance, diminishes vigilance, and disrupts daily functioning in hundreds of millions of people worldwide. Despite extensive research revealing significant variability in vigilance vulnerability to sleep deprivation, the underlying mechanisms of these individual differences remain elusive. Locus coeruleus (LC) plays a crucial role in the regulation of sleep-wake cycles and has emerged as a potential marker for vigilance vulnerability to sleep deprivation. In this study, we investigate whether LC microstructural integrity, assessed by fractional anisotropy (FA) through diffusion tensor imaging (DTI) at baseline before sleep deprivation, can predict impaired psychomotor vigilance test (PVT) performance during sleep deprivation in a cohort of 60 healthy individuals subjected to a rigorously controlled in-laboratory sleep study. The findings indicate that individuals with high LC FA experience less vigilance impairment from sleep deprivation compared with those with low LC FA. LC FA accounts for 10.8% of the variance in sleep-deprived PVT lapses. Importantly, the relationship between LC FA and impaired PVT performance during sleep deprivation is anatomically specific, suggesting that LC microstructural integrity may serve as a biomarker for vigilance vulnerability to sleep loss.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Locus coeruleus microstructural integrity is associated with vigilance vulnerability to sleep deprivation
- Date Crossref
- 01/09/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Guangdong Medical College pays non établi dans la noticeUniversité ou école supérieure
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University of Pennsylvania Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
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Shanghai International Studies University Key Laboratory of Brain‐Machine Intelligence for Information Behavior (Ministry of Education and Shanghai) pays non établi dans la noticeUniversité ou école supérieure
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School of Humanities and Management Guangdong Medical University Dongguan China The First Dongguan Affiliated Hospital pays non établi dans la noticeUniversité ou école supérieure
Guangdong Medical College, Department of Neurology — University of Pennsylvania et Key Laboratory of Brain‐Machine Intelligence for Information Behavior (Ministry of Education and Shanghai) — Shanghai International Studies University, avec 1 autre affiliation.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.