Vera Kolovratova

Extracorporeal photopheresis for the prevention of rejection after lung transplantation: a prospective randomised controlled trial

Alberto Benazzo, Ara Cho, Sophia Auner, Stefan Schwarz et autres

Background Lung transplant recipients have the worst long-term outcomes of all solid organs due to acute rejection and chronic lung allograft dysfunction (CLAD). Our objective was to investigate the efficacy of extracorporeal photopheresis (ECP) as a prophylactic treatment to prevent acute cellular …

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Prophylactic Extracorporeal Photopheresis to Prevent Acute Rejection after Lung Transplantation: A Prospective Randomized Controlled Trial

Péter Jaksch, Alberto Benazzo, Ara Cho, Sophia Auner et autres

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INTERCEPT Pathogen Reduction in Platelet Concentrates, in Contrast to Gamma Irradiation, Induces the Formation of trans-Arachidonic Acids and Affects Eicosanoid Release during Storage

Gerda C. Leitner, Gerhard Hagn, Laura Niederstaetter, Andrea Bileck et autres

Pathogen inactivation techniques for blood products have been implemented to optimize clinically safe blood components supply. The INTERCEPT system uses amotosalen together with ultraviolet light wavelength A (UVA) irradiation. Irradiation-induced inactivation of nucleic acids may actually be accompanied by modifications of chemically …

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INTERCEPT pathogen reduction of platelet concentrates induces trans-arachidonic acids and affects eicosanoid formation

Gerda C. Leitner, Gerhard Hagn, Laura Niederstätter, Andrea Bileck et autres

Abstract Gamma-irradiation of blood products is mandatory to avoid graft versus host disease in patients with immunosuppressed clinical conditions. Pathogen inactivation techniques were implemented to optimize safe blood component supply. The INTERCEPT treatment uses amotosalen together with UVA irradiation. The functional and …

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Granulocyte collection using a novel apheresis system eases the procedure and provides concentrates of high quality

Gerda C. Leitner, Vera Kolovratova, Michaela Horvath, Nina Worel

BACKGROUND: The latest technical innovation for granulocyte (PMN) collections is the fully automated Spectra Optia (Optia) device (TerumoBCT). In a retrospective investigation we evaluated the impact of the technical automation on the product quality in a routine working field. STUDY DESIGN AND …

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Administration of Prednisolone intravenously or Dexamethason orally in random donors reveals equal results in granulocyte collection: a single centre experience

Vera Kolovratova, Jana List, Nina Worel, Gerda C. Leitner

Since cytokine--mobilization for granulocyte collections in random donors--is not licensed in Austria, we investigated in a prospective analysis the effects of prednisolone or dexamethasone (DXM) in 153 donors (35 women/118 men) and in the collected products. Either prednisolone (50 mg) intravenously 4 …

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Inverse correlation of free and immune complex‐sequestered anti‐ADAMTS13 antibodies in a patient with acquired thrombotic thrombocytopenic purpura

Silvia Ferrari, Paul Knöbl, Vera Kolovratova, Barbara Plaimauer et autres

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Evolution of Anti-ADAMTS13 Antibodies in a Refractory Case of Thrombotic Thrombocytopenic Purpura with Fatal Outcome

Barbara Plaimauer, Paul N. Knoebl, Susanna Skalicky, Silvia Ferrari et autres

Abstract Thrombotic thrombocytopenic purpura (TTP) is characterized by systemic microvascular thrombosis leading to life-threatening ischemia of multiple organs, and is associated with a severe deficiency of the von Willebrand factor (VWF)-cleaving protease ADAMTS13, which permits highly adhesive ultra-large VWF multimers to accumulate …

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