Noha N. Yassen

Dose dependent toxicity of streptozotocin inducing diabetic complications in male Sprague Dawley rats with metabolic biochemical histopathological effects

Ahmed A. Sedik, Aliaa E. M. K. El‐Mosallamy, Noha N. Yassen, Nesma M E Abo El-Nasr

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia, leading to microvascular and macrovascular complications including cardiomyopathy, retinopathy, neuropathy, and nephropathy. This study evaluated the diabetogenic potential and pathological outcomes of two single intraperitoneal doses of streptozotocin (STZ) in …

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Radioprotective effects of quercetin and curcumin on hepatotoxicity and nephrotoxicity in male albino rats

Amr M. Abd El-Hady, Noha N. Yassen, Rady M. Azzoz, Said A. Ali

Ionizing radiation can cause significant harm to living tissues, prompting researchers to explore compounds with radioprotective potential to reduce side effects in radiotherapy patients. This study evaluated the protective effects of curcumin and quercetin, both individually and in combination, against γ-radiation-induced histopathological, …

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Chrysin matodextrin cationized guar complex nanoparticles modulates lung aging induced by D-galactose in mice: Forkhead box proteins impact in cell longevity and apoptosis

Abeer Salama, Eman Samy Shalaby, Noha N. Yassen, Mohamed F. Abdelhameed

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Chrysin ameliorates D-galactose-induced liver aging in mice: the impact of targeting Nrf2/AKT and CXCL1/TNF-α/P53 signaling pathways

Abeer Salama, Noha N. Yassen, Samar S. Khalaf, Mohamed I. Fahmy

OBJECTIVES: Liver aging is a major cause of death all over the world. D-galactose (D-gal) induces liver aging via inflammatory pathways in Kupffer cells. Chrysin (CHR) is a flavonoid having anti-inflammatory and antioxidant effects that can protect liver from aging responses. This …

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Immunohistochemical expression of GATA3, CK5/6 and CK20 in molecular subtypes of bladder carcinoma: correlation with clinicopathological features

Noha N. Yassen, Sonia L. El-Sharkawy, Naglaa F. Abbas, Marwa E. Shabana

Abstract Background Bladder urothelial carcinoma, is considered the 7th most common cancer in males. It is classified into luminal and basal subtypes depending on molecular markers, influencing prognosis and treatment. Identifying reliable biomarkers like GATA3, CK20, and CK5/6 through immunohistochemical methods can …

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Appraisal terpenoids rich Boswellia carterri ethyl acetate extract in binary cyclodextrin oligomer nano complex for improving respiratory distress

Bassant M. M. Ibrahim, Asmaa Badawy Darwish, Sally Abou Taleb, Reda M. Mourad et autres

Boswellia carterii (BC) resins plants have a long historical background as a treatment for inflammation, as indicated by information originating from multiple countries. Twenty-seven diterpenoids have been identified in ethyl acetate and total methanol BC, comprising seventeen boscartins of the cembrane-type diterpenoids …

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Expression of CD3+ and CD8+ tumor-infiltrating lymphocytes in prostatic carcinoma: immunohistochemical study and image analysis

Somia A.M. Soliman, Noha N. Yassen, Shereen E. Abdelaal, Marwa E. Shabana

Background Infiltrating immune cells have been reported as prognostic markers in many types of cancer. We aimed to assess the prognostic role of tumor-infiltrating lymphocytes, CD3+ cells, and CD8+ cells in prostatic cancer. Patients and methods Immunohistochemistry was used to determine the …

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Evaluation of the immunohistochemical expression of Nrf2, galectin-3, and CK19 in papillary thyroid carcinoma and its mimics

Dalia M. Abouelfadl, Marwa E. Shabana, Ahmed Soliman, Noha N. Yassen

Background The increasing incidence of papillary thyroid carcinoma (PTC) and inadequacy of routine histological examination in diagnosis and differentiation from its mimics necessitate the application of immunohistochemistry to deal with this issue. This study aimed to investigate the immunohistochemical expression of nuclear …

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Exploring the Potential of Nano-Encapsulated Elettaria Cardamom Oil as Anti-Alzheimer Agent

Omnia Aly, Magdi Ashour, Tahany R. Elias, Mervat Agaibyi et autres

Alzheimer's disease (AD) is a progressive neurodegenerative disease that contributes significantly to the global prevalence of dementia in the elderly population worldwide. The current study's goal is to examine the promising effects of cardamom oil in nano-encapsulated form, as a neuroprotective agent …

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Immunomorphometric Analysis of CD82 in Colorectal Carcinoma and its Prognostic Significance

Marwa E. Shabana, Ahmed S.A Soliman, Dalia M. Abouelfadl, Noha N. Yassen

Background: Colorectal carcinoma (CRC) is a highly aggressive tumor of the digestive tract, and its incidence and mortality rates are gradually rising. Tumor metastasis is considered a major obstacle to successful treatment. Therefore, assessing new biomarkers of CRC metastasis and prognosis is …

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Development and in vitro/in vivo evaluation of a nanosponge formulation loaded with Boswellia carterii oil extracts for the enhanced anti-inflammatory activity for the management of respiratory allergies

Sally Abou Taleb, Bassant M. M. Ibrahim, Mona A. Mohammed, Noha N. Yassen et autres

Abstract Purpose In several nations, it has been known that Boswellia carterii (BC) plants have a long history of usage as an anti-inflammatory medicine. Our current study deals with the study of two different ways of extraction of BC volatile oil and …

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Naringin alleviates liver damage induced by D-galactosamine (D-gal) in mice through down-regulation of CYP2E1 and P53 hyperactivity

Abeer Salama, Hanan El Shafeiy, Noha N. Yassen, Noha A. Mowaad

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