William N. Sanchez

Dopaminergic hypersensitivity of the opioid-responsive striatal–entopeduncular pathway in a rodent model of restless legs syndrome

Marta Valle-León, William Rea, César Quiroz, William N. Sanchez et autres

Abstract We hypothesized that Restless Legs Syndrome (RLS) and the restlessness of opioid withdrawal share common neurobiological mechanisms based on the efficacy of μ-opioid receptor (MOR) agonists in RLS and the common RLS-like phenotype of patients with opioid withdrawal. We also hypothesized …

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Hypersensitivity of the striatal striosomal dopamine D1 receptor-neuron in a rodent model of restless legs syndrome

Marta Valle-León, William Rea, César Quiroz, William N. Sanchez et autres

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Progesterone attenuates the effects of cocaine on hypermobility and dopaminergic transmission in the nucleus accumbens

William N. Sanchez, José Augusto Pochapski, A. Leslie Morrow, Roberto Andreatini et autres

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Distinctive biochemical properties of the μ-opioid receptor-corticotropin- releasing factor CRF1 receptor heterotetramer

William N. Sanchez, Estefanía Moreno, Marc Ciruela-Jardí, Nil Casajuana-Martín et autres

Heteromerization of Gs with Gi protein-coupled receptors has been suggested to be necessary to sustain the canonical Gi-Gs antagonistic interaction at adenylyl cyclase (AC). These heteromers have a tetrameric quaternary structure, composed by two homodimers each one coupled to its corresponding G …

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Dissection of Neurochemical Pathways Across Complexity and Scale

Alice Abbondanza, Nawon Kim, Ricardo A. S. Lima‐Filho, Azin Amin et autres

The field of Neurochemistry spent decades trying to understand how the brain works, from nano to macroscale and across diverse species. Technological advancements over the years allowed researchers to better visualize and understand the cellular processes underpinning central nervous system (CNS) function. …

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Biperiden reverses the increase in 50-kHz ultrasonic vocalizations but not the increase in locomotor activity induced by cocaine

Thais C.S. Saldanha, William N. Sanchez, Paola Palombo, Fábio C. Cruz et autres

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Forty-kHz ultrasonic vocalizations of rat pups predict adult behavior in the elevated plus-maze behavior but not the effect of cocaine on 50-kHz ultrasonic vocalizations

Nicolás F. Cordeiro, José Augusto Pochapski, William N. Sanchez, Gabriel C. Baltazar et autres

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Pathophysiology of Primary and Secondary Movement Disorders

Cláudio Da Cunha, William N. Sanchez, Fernando Henrique Teixeira Zonzini, Daniel R. Benke et autres

Abstract Primary and secondary movement disorders can present different etiologies and physiopathology. However, the malfunctioning of the corticobasal ganglia loops is implicated in most movement disorders. Hypokinetic signs such as bradykinesia, rigidity, gait disturbance, micrographia, precision grip impairment, and speech problems are …

Pre-clinical evidence that methylphenidate increases motivation and/or reward preference to search for high value rewards

Laura N. Pulido, José Augusto Pochapski, Adam H. Sugi, Julie Y. Esaki et autres

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Diazepam attenuates the effects of cocaine on locomotion, 50‐kHz ultrasonic vocalizations and phasic dopamine in the nucleus accumbens of rats

William N. Sanchez, José Augusto Pochapski, Leticia F. Jessen, Marek Ellenberger et autres

BACKGROUND AND PURPOSE: Currently, there is no effective drug to treat cocaine-use disorder, which affects millions of people worldwide. Benzodiazepines are potential therapeutic candidates, as microdialysis and voltammetry studies have shown that they can decrease dopamine concentrations in the nucleus accumbens of …

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Diazepam attenuates the effects of cocaine on locomotion, 50-kHz ultrasonic vocalizations and phasic dopamine release in the nucleus accumbens of rats

William N. Sanchez, José Augusto Pochapski, Leticia F. Jessen, Marek Ellenberger et autres

Abstract Background and Purpose Currently, no effective drug exists to treat cocaine use disorders, which affect millions of people worldwide. Benzodiazepines are potential therapeutic candidates, as microdialysis and voltammetry studies have shown that they can decrease dopamine release in the nucleus accumbens …

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Structure and Biological Properties of Lasiodiplodan: An Uncommon Fungal Exopolysaccharide of the (1 → 6)-β-D-Glucan Type

Mário Antônio Alves da Cunha, Vidiany Aparecida Queiroz Santos, Gabrielle Cristina Calegari, William N. Sanchez et autres

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