Roberto Adamo

Synthesis and Immunological Evaluation of Pel-Derived Glycoconjugate Vaccine Candidates against Pseudomonas aeruginosa

Dung-Yeh Wu, Linda Del Bino, Giacomo Romagnoli, Gijsbert A. van der Marel et autres

High Resolution Image Download MS PowerPoint Slide Pseudomonas aeruginosa is an antibiotic-resistant pathogen and leading cause of hospital-acquired infections. Its ability to form biofilms enables persistent colonization by protecting bacterial cells from antibiotics and host immune action. The Pel exopolysaccharide is a …

nl, it (code pays fourni par la source)

Immune responses to glycoconjugate vaccines rely on a balance between polysaccharide length and glycosylation density

Filippo Carboni, Nicoletta Bechi, Daniela Proietti, Cristiana Balocchi et autres

Glycoconjugate vaccines are effective against bacterial infections. Key characteristics for optimal immunogenicity are the carbohydrate-to-protein ratio and consequent glycosylation density. Directing the conjugation to specific sites is beneficial when the protein acts as carrier and antigen, however a caveat of this approach …

it, be (code pays fourni par la source)

Vaccines preventing neonatal sepsis: focus on Group B Streptococcus , Klebsiella pneumoniae and Escherichia coli to combat rising antimicrobial resistance

Francesca Micoli, Simona Rondini, Francesco Berlanda Scorza, Roberto Adamo

Introduction Neonatal sepsis, a systemic infection occurring in infants within their first 28 days of life, is a leading cause of mortality globally. The burden is especially severe in low- and middle-income countries (LMICs), where incidence and mortality rates are higher than …

us (code pays fourni par la source)

An mRNA-based FimH nanoparticle vaccine against uropathogenic Escherichia coli is highly immunogenic in rodents

Sandro Roier, Roberto Adamo, Roberto Rosini, Alfredo Pezzicoli et autres

Background Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections (UTIs), which are increasingly antibiotic resistant and frequently recur. Novel therapeutics are sought to treat and prevent recurrent UTIs (rUTIs), including vaccines. Key virulence factor FimH, which mediates bacterial …

de (code pays fourni par la source)

Synthesis, Conformal Analysis, and Antibody Binding of Staphylococcus aureus Capsular Polysaccharide Type 5 Oligosaccharides

Kitt Emilie Østerlid, Sizhe Li, Luca Unione, Linda Del Bino et autres

Abstract Staphylococcus aureus is one of the most prominent pathogens responsible for life‐threatening hospital acquired infections. Most clinical isolates belong to serotype 5 or 8, which express unique capsular polysaccharides (CP), composed of the rare N ‐acetyl‐β‐ d ‐mannosaminuronic acid (β‐ d …

nl, es, it (code pays fourni par la source)

Synthesis, Conformal Analysis, and Antibody Binding of Staphylococcus aureus Capsular Polysaccharide Type 5 Oligosaccharides

Kitt Emilie Østerlid, Sizhe Li, Luca Unione, Linda Del Bino et autres

Abstract Staphylococcus aureus is one of the most prominent pathogens responsible for life‐threatening hospital acquired infections. Most clinical isolates belong to serotype 5 or 8, which express unique capsular polysaccharides (CP), composed of the rare N ‐acetyl‐β‐ d ‐mannosaminuronic acid (β‐ d …

nl, es, it (code pays fourni par la source)

Author response for "Multimeric, Multivalent Fusion Carrier Proteins for Site-Selective Glycoconjugate Vaccines Simultaneously Targeting Staphylococcus aureus and Pseudomonas aeruginosa"

Charlotte Sorieul, Bartal Mikladal, Dung‐Yeh Wu, Cinzia Giovani et autres

Long, Synthetic Staphylococcus aureus Type 8 Capsular Oligosaccharides Reveal Structural Epitopes for Effective Immune Recognition

Kitt Emilie Østerlid, Charlotte Sorieul, Luca Unione, Sizhe Li et autres

High Resolution Image Download MS PowerPoint Slide Staphylococcus aureus is a Gram-positive bacterium that is responsible for severe nosocomial infections. The rise of multidrug-resistant strains, which can pose significant health threats, prompts the development of new treatment interventions, and much attention has …

nl, es (code pays fourni par la source)

Multimeric, multivalent fusion carrier proteins for site-selective glycoconjugate vaccines simultaneously targeting Staphylococcus aureus and Pseudomonas aeruginosa

Charlotte Sorieul, Bartal Mikladal, Dung‐Yeh Wu, Barbara Brogioni et autres

, respectively. A conjugation strategy based on selective targeting of a purposefully introduced histidine tag was developed to preserve the structure and antigenicity of epitopes from the two proteins, leveraging their dual role as a carrier and antigen. This multivalent, multimeric and …

nl (code pays fourni par la source)

Semisynthetic Glycoconjugates as Potential Vaccine Candidates Against Haemophilus influenzae Type a

Claudia Kohout, Linda Del Bino, Laura Petrosilli, Giuseppe D’Orazio et autres

Abstract Glycoconjugate vaccines are based on chemical conjugation of pathogen‐associated carbohydrates with immunogenic carrier proteins and are considered a very cost‐effective way to prevent infections. Most of the licensed glycoconjugate vaccines are composed of saccharide antigens extracted from bacterial sources. However, synthetic …

it, us, nl (code pays fourni par la source)

Antigenic determinants driving serogroup-specific antibody response to Neisseria meningitidis C, W, and Y capsular polysaccharides: Insights for rational vaccine design

Gian Pietro Pietri, Sara Bertuzzi, Katarina Karničar, Luca Unione et autres

Meningococcal glycoconjugate vaccines sourced from capsular polysaccharides (CPSs) of pathogenic Neisseria meningitidis strains are well-established measures to prevent meningococcal disease. However, the exact structural factors responsible for antibody recognition are not known. CPSs of Neisseria meningitidis serogroups Y and W differ by …

hr, es, si (code pays fourni par la source)

Vaccines and Monoclonal Antibodies as Alternative Strategies to Antibiotics to Fight Antimicrobial Resistance

Chiara La Guidara, Roberto Adamo, Claudia Corina Sala, Francesca Micoli

Antimicrobial resistance (AMR) is one of the most critical threats to global public health in the 21st century, causing a large number of deaths every year in both high-income and low- and middle-income countries. Vaccines and monoclonal antibodies can be exploited to …

it (code pays fourni par la source)