Allison Hanley

Epidemiologic and Clinical Features of Mpox-Associated Deaths — United States, May 10, 2022–March 7, 2023

Aspen Riser, Allison Hanley, Michael J. Cima, Linda Lewis et autres

(1.3 per 1,000 mpox cases) were reported to CDC and classified as mpox-associated (i.e., mpox was listed as a contributing or causal factor). Among the 38 mpox-associated deaths, 94.7% occurred in cisgender men (median age = 34 years); 86.8% occurred in non-Hispanic …

Juvéderm emerges as the newest hyaluronic acid dermal filler

Allison Hanley

Allison Hanley just graduated from the Quinnipiac University PA program, Hamden, CT. The author has indicated no relationships to disclose relating to the content of this article.

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CD34-Positive Cells Exhibit Increased Potency and Safety for Therapeutic Neovascularization After Myocardial Infarction Compared With Total Mononuclear Cells

Atsuhiko Kawamoto, Hiroto Iwasaki, Kengo Kusano, Toshinori Murayama et autres

BACKGROUND: We compared the therapeutic potential of purified mobilized human CD34+ cells with that of mobilized total mononuclear cells (tMNCs) for the preservation/recovery of myocardial tissue integrity and function after myocardial infarction (MI). METHODS AND RESULTS: CD34+ cells were purified from peripheral …

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Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF

Gangjian Qin, Raj Kishore, Christine Dolan, Marcy Silver et autres

The transcription factor E2F1 is known to regulate cell proliferation and has been thought to modulate tumorigenesis via this mechanism alone. Here we show that mice deficient in E2F1 exhibit enhanced angiogenesis. The proangiogenic phenotype in E2F1 deficiency is the result of …

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The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-α–induced transcriptional repression of cyclin A

Raj Kishore, Gangjian Qin, Corinne Luedemann, Evelyn Bord et autres

TNF-alpha modulates EC proliferation and thereby plays a central role in new blood vessel formation in physiologic and pathologic circumstances. TNF-alpha is known to downregulate cyclin A, a key cell cycle regulatory protein, but little else is known about how TNF-alpha modulates …

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Progressive Attenuation of Myocardial Vascular Endothelial Growth Factor Expression Is a Seminal Event in Diabetic Cardiomyopathy

Young‐sup Yoon, Shigeki Uchida, Osamu Masuo, Manfred Cejna et autres

BACKGROUND: Diabetic cardiomyopathy (DCM) is characterized by microvascular pathology and interstitial fibrosis, which leads to progressive heart failure; however, the pathogenesis of DCM remains uncertain. METHODS AND RESULTS: Using the streptozotocin-induced diabetic rat model, we evaluated the natural course of DCM over …

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Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction

Young‐sup Yoon, Andrea Wecker, Lindsay Heyd, Jong‐Seon Park et autres

We have identified a subpopulation of stem cells within adult human BM, isolated at the single-cell level, that self-renew without loss of multipotency for more than 140 population doublings and exhibit the capacity for differentiation into cells of all 3 germ layers. …

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Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction

Young‐sup Yoon, Andrea Wecker, Lindsay Heyd, Jong‐Seon Park et autres

We have identified a subpopulation of stem cells within adult human BM, isolated at the single-cell level, that self-renew without loss of multipotency for more than 140 population doublings and exhibit the capacity for differentiation into cells of all 3 germ layers. …

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Synergistic Effect of Bone Marrow Mobilization and Vascular Endothelial Growth Factor-2 Gene Therapy in Myocardial Ischemia

Atsuhiko Kawamoto, Toshinori Murayama, Kengo Kusano, Masaaki Ii et autres

BACKGROUND: We performed a series of investigations to test the hypothesis that combining angiogenic gene therapy and cytokine (CK)-induced endothelial progenitor cell mobilization would be superior to either strategy alone for treatment of chronic myocardial ischemia. METHODS AND RESULTS: A swine model …

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Secretoneurin, an Angiogenic Neuropeptide, Induces Postnatal Vasculogenesis

Rudolf Kirchmair, Margot Egger, Dirk Walter, Wolfgang Eisterer et autres

BACKGROUND: Induction of postnatal vasculogenesis, the mobilization of bone marrow-derived endothelial progenitor cells and incorporation of these cells into sites of blood vessel formation, is a well-known feature of angiogenic cytokines such as vascular endothelial growth factor. We hypothesized that the angiogenic …

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Local Gene Transfer of phVEGF-2 Plasmid by Gene-Eluting Stents

Dirk Walter, Manfred Cejna, Larry J. Díaz‐Sandoval, Sean L. Willis et autres

BACKGROUND: Drug-eluting stents represent a useful strategy for the prevention of restenosis using various antiproliferative drugs. These strategies share the liability of impairing endothelial recovery, thereby altering the natural biology of the vessel wall and increasing the associated risk of stent thrombosis. …

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The Neuropeptide Secretoneurin Acts as a Direct Angiogenic Cytokine In Vitro and In Vivo

Rudolf Kirchmair, Roland Gander, Margot Egger, Allison Hanley et autres

BACKGROUND: Secretoneurin is an abundant neuropeptide of the central, peripheral, and autonomic nervous systems, located in nerve fibers characterized by a close interaction with blood vessels and known to stimulate endothelial cell migration. METHODS AND RESULTS: We hypothesized that secretoneurin might act …

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