Accès ouvert
2026
article
OpenAlex
Sharon Weidmann, Silvana Ebner, Aayushi Srivastava, Armin Wiegering et autres
INTRODUCTION: IDH1 mutations occur in approximately 10%-20% of intrahepatic cholangiocarcinoma (iCCA) and constitute an established target for molecularly guided therapy. As routine molecular diagnostics are commonly based on a single tumour sample, intratumoral heterogeneity could affect the reliable detection of actionable mutations. …
de
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Accès ouvert
2025
article
OpenAlex
Sabrina Welland, A Zöller, Ilektra A. Mavroeidi, Aurelie Tomczak et autres
Background & Aims Biliary tract cancers (BTC) comprise a group of aggressive malignancies with limited therapeutic options. Owing to the high frequency of actionable genomic alterations (GA) and the availability of targeted therapies, molecular testing has gained increasing importance; however, its implementation …
de, at, ca
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2025
conference-paper
OpenAlex
Maximilian N. Kinzler, Steffen Gretser, Falko Schulze, Katrin Bankov et autres
Einleitung: Die Anti-Claudin-18.2-Therapie (CLDN18.2) wurde kürzlich für die Behandlung von Adenokarzinomen des Magens oder des gastroösophagealen Übergangs zugelassen. Ziele: Ziel der vorliegenden Studie war es, erstmalig die Expression von CLDN18.2 im Cholangiokarzinom (CCA) zu untersuchen, um festzustellen, ob es Subgruppen von Patienten …
de
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Accès ouvert
2025
article
OpenAlex
Maximilian N. Kinzler, Eric Metzger, Katrin Bankov, Anna Ramos-Triguero et autres
PURPOSE: The newly discovered histone methyltransferase KMT9 serves as an epigenetic regulator of carcinogenesis in various cancer entities. For the first time, we investigated the presence of KMT9α in cholangiocarcinoma, the association with histologic subtypes, and its impact on survival. METHODS: A …
de
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Accès ouvert
2025
article
OpenAlex
Alica Kubesch, Alexander Schütz, Georg Dultz, Fabian Finkelmeier et autres
Introduction: Treating biliary obstruction remains a common clinical problem. Endoscopic retrograde cholangiopancreatography (ERCP) with stent insertion remains the gold standard. If ERCP fails, percutaneous transhepatic biliary drainage (PTBD) is one treatment option. Despite a high success rate, early- and late-onset complications occur …
de
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2025
conference-paper
OpenAlex
Christiana Graf, A. W. Mondorf, C Welkerling, D Hessz et autres
Aims Enteral nutrition is crucial for managing patients with swallowing difficulties, particularly those with head and neck cancers or neurological disorders. Percutaneous endoscopic gastrostomy (PEG) has become the standard method for providing enteral nutrition, with two primary techniques: the “pull-through” technique and …
de
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Accès ouvert
2025
article
OpenAlex
Melanie Winter, Silvana Ebner, Nina Scheuber, Falko Schulze et autres
Background: Cholangiocarcinoma, a malignancy originating from the bile ducts, poses significant treatment challenges due to its typically late diagnosis and limited therapeutic options. However, recent advances in molecular genetics enable more personalized treatment approaches. A notable breakthrough in this context is the …
de
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Accès ouvert
2024
article
OpenAlex
Maximilian N. Kinzler, Steffen Gretser, Falko Schulze, Katrin Bankov et autres
Aims Anti‐claudin‐18.2 (CLDN18.2) therapy was recently approved for the treatment of gastric or gastro‐oesophageal junction adenocarcinoma. The aim of the present study was to investigate the expression of CLDN18.2 in cholangiocarcinoma (CCA) to determine whether there is a subgroup of patients who …
de
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Accès ouvert
2024
article
OpenAlex
Florian Alexander Michael, Michael J. Jung, M. Reimers, C. Oschwald et autres
INTRODUCTION: International guidelines suggest different possibilities for drying of endoscopes during reprocessing. Clinical results of these available drying methods are not satisfactory. The aim of this study was to compare the drying cycle of a standard endoscope washer-disinfector (EWD) (standard drying method …
de
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Accès ouvert
2024
article
OpenAlex
Florian Alexander Michael, Clara Feldmann, Hans‐Peter Erasmus, Alica Kubesch et autres
Before removal of retained pancreatic stents placed during endoscopic retrograde cholangiopancreatography to avoid post-ERCP pancreatitis, imaging is recommended. The aim of the present study was to evaluate a new ultrasound-based algorithm.Patients who received a pancreatic stent for PEP prophylaxis were included. Straight …
de
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Accès ouvert
2024
article
OpenAlex
Simon Bernatz, Falko Schulze, Julia Bein, Katrin Bankov et autres
PURPOSE: Dedicated gene signatures in small (SD-iCCA) and large (LD-iCCA) duct type intrahepatic cholangiocarcinoma remain unknown. We performed immune profiling in SD- and LD-iCCA to identify novel biomarker candidates for personalized medicine. METHODS: Retrospectively, 19 iCCA patients with either SD-iCCA (n = …
de
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Accès ouvert
2024
article
OpenAlex
Maximilian N. Kinzler, Falko Schulze, Jan Jeroch, Christina Schmitt et autres
AIMS: The histological subtype of intrahepatic cholangiocarcinoma (iCCA) is associated with different mutational characteristics that impact clinical management. So far, data are lacking on the presence of small duct iCCA (SD-iCCA) and large duct iCCA (LD-iCCA) in a single patient. The aim …
de
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