István Arany

Chronic Nicotine Accelerates Renal Injury and Cardiac Dysfunction Via Pressure Independent Actions of Endothelin and the Heme Oxygenase System

Kiran Chandrashekar, Rodrigo Oscar Maranon, Nicholas Juncos, István Arany et autres

Background and Aim We examined potential mechanisms by which chronic nicotine (NIC) acts as a catalyst for renal, cardiac and vascular injury. Since, NIC enhances AngII‐induced increases in endothelin and blood pressure (BP), and decreases cyto‐protective HO responses, we tested the role …

us (code pays fourni par la source)

Adverse effects of chronic nicotine exposure on the kidney: Potential human health implications of experimental findings

István Arany, Mary L. Taylor, Tibor Fülöp, Mehul P. Dixit

With the increasing popularity of E-cigarettes, chronic exposure to nicotine (NIC) is emerging as a novel risk factor for the kidney. NIC increases oxidative stress in the kidneys, which impairs the viability and function of renal tubular and endothelial cells, alters renal …

Baclofen-induced neurotoxicity in patients with compromised renal function: Review

Sohail Abdul Salim, Litty Thomas, Anand Achanti, Monika Beck Gooz et autres

Baclofen is a centrally-acting γ-amino butyric acid agonist used mainly in the symptomatic management of spasticity originating from the spinal cord. It is absorbed completely from the gastrointestinal tract, metabolized by the liver to a minor degree, and excreted unchanged by the …

Chronic Nicotine Exposure Reduces Antioxidant Function of Simvastatin in Renal Proximal Tubule Cells

István Arany, Tibor Fülöp, Mehul P. Dixit

BACKGROUND/AIM: We have previously reported that simvastatin exhibits antioxidant properties via extracellular signal-regulated kinase (ERK)/cAMP-response element binding (CREB) protein-dependent induction of heme oxygenase-1 (HO1) and chronic nicotine exposure inhibits ERK/CREB signaling in renal proximal tubule cells (through p66shc). Herein, whether nicotine dampens …

us (code pays fourni par la source)

Peritoneal dialysis: The unique features by compartmental delivery of renal replacement therapy

Tibor Fülöp, Lajos Zsom, Mihaly B. Tapolyai, Miklos Zsolt Molnar et autres

hu, us (code pays fourni par la source)

Nicotine Exposure Augments Renal Toxicity of 5-azacytidine Through p66shc: Prevention by Resveratrol

István Arany, Samuel Hall, Amir Faisal, Mehul P. Dixit

BACKGROUND/AIM: We have shown that either chronic nicotine (NIC) exposure or 5-aza-cytidine (AZA) augments oxidative stress-dependent injury through stimulating p66shc in renal cells. Hence, NIC could exacerbate adverse effects of AZA while antioxidants such as resveratrol (RES) could prevent it. MATERIALS AND …

us, pk (code pays fourni par la source)

Simvastatin Inhibits Epithelial-to-Mesenchymal Transition Through Induction of HO-1 in Cultured Renal Proximal Tubule Cells.

Jeb S. Clark, Anthony J. Carter, Mehul P. Dixit, István Arany

BACKGROUND/AIM: Studies have shown that simvastatin (SIM) inhibits epithelial-mesenchymal transition (EMT), a key step in fibrosis, and activates the anti-fibrotic heme oxygenase-1 (HO-1) gene in renal proximal tubule cells independent of its lipid-lowering. We tested the hypothesis that SIM inhibits EMT via …

us (code pays fourni par la source)

Epigenetic memory of oxidative stress: does nephrilin exert its protective effects via Rac1?

Desmond D. Mascarenhas, David N. Herndon, István Arany

Aim: Nephrilin peptide, a designed inhibitor of Rictor complex (mTORC2), exerts pleiotropic protective effects in metabolic, xenobiotic and traumatic stress models. Stress can generate enduring epigenetic changes in gene function. In this work we examine the possibility that nephrilin treatment protects against …

us (code pays fourni par la source)

Age-dependent sensitivity of the mouse kidney to chronic nicotine exposure

István Arany, Samuel Hall, Mehul P. Dixit

us (code pays fourni par la source)

Resveratrol Attenuates Nicotine-mediated Oxidative Injury by Inducing Manganese Superoxide Dismutase in Renal Proximal Tubule Cells

Samuel Hall, Mehul P. Dixit, István Arany

BACKGROUND/AIM: Nicotine (NIC) exposure - via smoking and the increasingly popular E-cigarettes- increases oxidative stress and hence, renal risk in smokers. Resveratrol (RES) may help ameliorate this risk by mounting anti-oxidant responses in the kidney. MATERIALS AND METHODS: Renal proximal tubule cells …

us (code pays fourni par la source)

Differential roles of 3-Hydroxyflavone and 7-Hydroxyflavone against nicotine-induced oxidative stress in rat renal proximal tubule cells

Bidisha Sengupta, Mehdi Sahihi, Monireh Dehkhodaei, Darrian Kelly et autres

Plant flavonoids are well known as antioxidants against oxidative stress induced by exposure to external pollutants. Nicotine (NIC) is one of those agents which increases renal oxidative stress, an important factor in the pathogenesis of renal epithelial injury in smokers. Although several …

us, ir (code pays fourni par la source)

Prenatal Nicotine Exposure Augments Renal Oxidative Stress in Embryos of Pregnant Rats with Reduced Uterine Perfusion Pressure.

Norma Beatriz Ojeda, Samuel Hall, Cara Lasley, Benjamin Rudsenske et autres

BACKGROUND/AIM: Both maternal nicotine (NIC) exposure and placental insufficiency increase oxidative stress in the fetal kidney ensuing fetal programming of renal diseases in adult life. Their combined effects, however, are unknown. We tested the hypothesis that maternal NIC exposure exacerbates renal oxidative …

us (code pays fourni par la source)