Luke Carson

What is an algorithm worth? The enduring value of the dermatologist

Ravi Ramessur, Luke Carson

gb, us, au (code pays fourni par la source)

A single-centre, retrospective cohort study of paediatric tinea capitis in the United Kingdom

Elliot Herd, Louis C. S. Gardner, Suzy Leech, Daniel Weiand et autres

Abstract Background Contemporary understanding of the epidemiology and clinical spectrum of paediatric tinea capitis in the UK is limited, with implications for both clinical management and public health interventions. Objectives To examine recent trends in the incidence, clinical presentation and microbiological profiles …

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Novel cutaneous adverse effects of the increasingly prevalent glucagon-like peptide 1 agonists

Luke Carson, Mark D. Eisner, Caroline Launay, Suzy Leech et autres

Abstract Prescribing of the glucagon-like peptide 1 receptor agonists (GLP-1RA) is rapidly increasing as their efficacy for multiple indications becomes apparent. A better understanding of their cutaneous adverse effect profile is crucial, particularly as they are suggested for use in inflammatory dermatoses. …

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Real-world effectiveness of artificial-intelligence-assisted lesion triage on cancer waiting times

Luke Carson, R. J. Fleming, Emma Lennard, Rubeta N Matin et autres

Urgent skin cancer referrals are increasing, and artificial intelligence (AI) tools have been proposed as a solution to the considerable pressure on dermatology services. Using publicly available cancer waiting time data from 24 National Health Service trusts, this real-world interrupted time series …

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P17 Ontological analysis of a curated dataset of genetic skin diseases reveals enrichment of key processes that are disrupted in cutaneous biology

Tania A Agathangelidi, Luke Carson, Brent J. Doolan, Joe Inns et autres

Abstract Introduction and aims Genomic testing and precision medicine are revolutionizing dermatological practice, with the genetic basis of many inherited and mosaic skin diseases now solved. However, an unbiased, ontological analysis of these known disease-­causing genes is lacking, which could inform the …

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O08 The elemental clue: a case series of Acrodermatitis enteropathica in a tertiary centre

Pooja Jassal-Prior, Luke Carson, Suzy Leech, Anna Dubois et autres

Acrodermatitis enteropathica (AE) is a rare disorder of zinc deficiency which may be hereditary or acquired. Hereditary AE is an autosomal recessive disorder caused by defects in the zinc transporter gene SLC39A4, resulting in impaired intestinal absorption of zinc. Acquired AE arises …

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P02 A single-centre, retrospective study of paediatric tinea capitis in the United Kingdom

Elliot Herd, Louis C. S. Gardner, Suzy Leech, Daniel Weiand et autres

BACKGROUND: The clinical and microbiological spectrum of paediatric tinea capitis in the United Kingdom has not been recently reported. This study evaluates recent changes in the incidence, clinical presentation, and microbiological spectrum of paediatric tinea capitis over the past nine years. METHODS: …

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An ontological analysis of a dataset of curated dermatological gene–disease associations (G2P-Skin)

Tania A Agathangelidi, Luke Carson, Brent J. Doolan, Anna Dubois et autres

More than 607 genodermatoses have been associated with pathogenic variants in 477 genes, which are captured in the updated Genotype 2 Phenotype (G2P) Skin dataset. Here we report: (i) the utility of this clinically curated database for the annotation of genetic variants …

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A Single‐Center Case Series With Visual Analysis of Pediatric Linear Scleroderma

Luke Carson, Adam Pattison Rathbone, Charlotte Goodhead, Sunil Sampath

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Uncommon cause of percutaneous fistulation

Luke Carson, Melanie C. Page, Robert P. Holmes, David M. Brass

We report the case of a woman in her mid-60s with a 9 month history of a lesion to the right posterolateral flank presenting as a gradually enlarging, inflamed pink papule, which developed into a fistulating sinus tract discharging onto the skin. …

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DS21 Mohs surgeons had higher rates of detecting missed margins than consultant histopathologists when auditing Mohs slides

Louis C. S. Gardner, Luke Carson, Thomas Oliphant

Abstract We aimed to determine whether there was any difference between the rate of concordance in audit of slides between Mohs surgeons and dermatopathologists. All digitally stored Mohs micrographic surgery audit cases from 2012 onwards were accessed and reviewed. In total 82 …

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PA08 The use of dupilumab for complex dermatoses: a case series

Luke Carson, Charlotte Goodhead, Anna Dubois, Suzy Leech

Abstract Dupilumab is a biologic inhibitor of interleukin-4 and interkeukin-13 that is licensed for children aged ≥ 6 months with severe eczema. We present a case series of five children where dupilumab was used for atypical indications, or in complex cases where …

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