Denise Morotti

45P Rare and non-canonical ALK fusion in advanced NSCLC: Heterogeneous clinical outcomes with ALK inhibitors

Salvatore Intagliata, Nicoletta Bianchi, Graciela Ghirardi, M. Cardisperi et autres

ALK rearrangements define a clinically relevant subset of non-small cell lung cancer (NSCLC) sensitive to ALK tyrosine kinase inhibitors (TKIs). While EML4–ALK is the most frequent fusion, next-generation sequencing (NGS) has enabled the identification of rare ALK fusion partners, whose clinical behavior …

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NGS-based molecular profiling for druggable mutations in metastatic prostate cancer: A single-institution experience

Lucia Bonomi, Denise Morotti, Silvio Sporeni, M. Cardisperi et autres

134P Unmasking actionable mutations in HR+/HER2–metastatic breast cancer: Real-world insights from Avida DNA OncoLiquid BiopsyNGS combined with methylation index

Federica Bini, M. Cardisperi, Rita De Sanctis, Alessandra Chirco et autres

Background: In HR+/HER2-metastatic breast cancer (MBC), ESR1 and/or PI3K pathway (PIK3CA, AKT1 and PTEN) mutations guide post-first-line therapeutic strategies.We report data on mutation prevalence in MBCs patients (pts) assessed via Avida Duo Liquid Biopsy (LB)-NGS based (Agilent Technologies) at ASST PGXXIII, Bergamo …

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686 | TABELECLEUCEL IN EBV POSITIVE POST‐TRANSPLANT LYMPHOPROLIFERATIVE DISEASE: A REAL WORD EXPERIENCE

Anna Maria Barbui, Muriel Paganessi, Silvia Ferrari, Alessandra Algarotti et autres

For constipation drugs, the respective prescription incidences in each age group were 84.7% (77.8-90.2),89.1% (83.8-93.1),89.8% (86.2-92.8),and 91.5% (85.9-95.4) in the Pola-R-CHP group and 87.1% (82.2-91.1),89.7% (85.9-92.8),95.4% (93.4-97.0),and 94.4% (91.9-96.4) in the R-CHOP group.Incidence of stimulant laxative prescriptions tended to increase with age …

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In Situ Analyses of Placental Inflammatory Response to SARS-CoV-2 Infection in Cases of Mother–Fetus Vertical Transmission

Denise Morotti, Silvia Tabano, Gabriella Gaudioso, Tatjana Radaelli et autres

It has been shown that vertical transmission of the SARS-CoV-2 strain is relatively rare, and there is still limited information on the specific impact of maternal SARS-CoV-2 infection on vertical transmission. The current study focuses on a transcriptomics analysis aimed at examining …

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Non-Small Cell Lung Cancer Testing on Reference Specimens: An Italian Multicenter Experience

Francesco Pepe, Gianluca Russo, Alessandro Venuta, Claudia Scimone et autres

INTRODUCTION: Biomarker testing is mandatory for the clinical management of patients with advanced non-small cell lung cancer (NSCLC). Myriads of technical platforms are now available for biomarker analysis with differences in terms of multiplexing capability, analytical sensitivity, and turnaround time (TAT). We …

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EP06.05-06 Distant Metastasis Pattern and Baseline Clinicopathological Features from a Real-World KRAS G12C Mutant Cohort of Advanced NSCLC Patients

Luigina Mollica, Salvatore Intagliata, Lucia Bonomi, Laura Ghilardi et autres

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116P Switching to a multigenic parallel sequencing approach: The landscape of biomarkers profiling changing between immunohistochemistry and next generation sequencing advantages and sustainability from a public hospital in Northern Italy

Graciela Ghirardi, Brigitte Bisarò, Elena Antelmi, F. Paleni et autres

Thrombotic Features as the Primary Cause of SARS‐CoV‐2 Related Acute Abdomen in Children

Angela Amoroso, Fabiana Di Stasio, Giusy Ranucci, Pietro Betalli et autres

OBJECTIVES: We performed a retrospective case control study to evaluate the histological characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive pediatric patients undergoing laparoscopic exploration for acute abdomen symptoms. To our knowledge this is the first study that analyzes histopathological …

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SARS-CoV-2 Detection by Digital Polymerase Chain Reaction and Immunohistochemistry in Skin Biopsies from 52 Patients with Different COVID-19-Associated Cutaneous Phenotypes

Angelo Valerio Marzano, Chiara Moltrasio, Giovanni Genovese, Marco De Andrea et autres

BACKGROUND: COronaVIrus Disease 19 (COVID-19) is associated with a wide spectrum of skin manifestations, but SARS-CoV-2 RNA in lesional skin has been demonstrated only in few cases. OBJECTIVE: The objective of this study was to demonstrate SARS-CoV-2 presence in skin samples from …

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Supplementary Material for: SARS-CoV-2 detection by digital polymerase chain reaction and immunohistochemistry in skin biopsies from 52 patients with different COVID-19-associated cutaneous phenotypes

Marzano A.V., C. Moltrasio, Giovanni Genovese, Maurilio Deandrea et autres

Background: COronaVIrus Disease 19 (COVID-19) is associated with a wide spectrum of skin manifestations, but SARS-CoV-2 RNA in lesional skin has been demonstrated only in few cases. Objective: To demonstrate SARS-CoV-2 presence in skin samples from patients with different COVID-19-related cutaneous phenotypes. …

Evidence of vertical transmission of SARS-CoV-2 and interstitial pneumonia in second-trimester twin stillbirth in asymptomatic woman. Case report and review of the literature

Luisa Patanè, Massimiliano Cadamuro, Gabriella Massazza, Serena Pirola et autres

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