Liekele E. Oostenbrug

Surveillance vs Standard Surgery and Cost-Effectiveness After Neoadjuvant Chemoradiotherapy for Esophageal Cancer: Secondary Analysis of a Randomized Clinical Trial

Sanjiv S G Gangaram Panday, David van Klaveren, Sjoerd M Lagarde, Berend J van der Wilk et autres

Importance: Active surveillance is noninferior to standard surgery for 2-year survival and improves short-term health-related quality of life among patients with a complete clinical response (CCR) after neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer. Although active surveillance reduces the upfront costs of surgery …

Ileocaecal resection versus infliximab for ileal Crohn's disease: retrospective 10-year follow-up of the LIR!C trial

Lotte Oldenburg, Anouck E G Haanappel, Mahsoem Ali, Carolijn Bosman et autres

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Safety of surveillance endoscopy and EUS of the esophagus after neoadjuvant chemoradiotherapy: Results from the (pre)SANO trial

S Panday, Low Kuan Yean, Tanya M. Bisseling, Wouter L. Curvers et autres

Abstract Active surveillance has been proposed for patients with esophageal cancer and a clinical complete response after neoadjuvant chemoradiotherapy (nCRT). This strategy involves repeated esophagogastroduodenoscopy (EGD) with bite-on-bite biopsies and endoscopic ultrasonography (EUS) with fine-needle aspiration (FNA) to detect tumor regrowth or …

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Neoadjuvant chemoradiotherapy followed by active surveillance versus standard surgery for oesophageal cancer (SANO trial): a multicentre, stepped-wedge, cluster-randomised, non-inferiority, phase 3 trial

Berend J. van der Wilk, Ben M. Eyck, Bas P. L. Wijnhoven, Sjoerd M. Lagarde et autres

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796. P02.05 NEOADJUVANT CHEMORADIOTHERAPY FOLLOWED BY ACTIVE SURVEILLANCE VERSUS STANDARD SURGERY FOR OESOPHAGEAL CANCER (SANO-TRIAL): A MULTICENTRE STEPPED-WEDGE CLUSTER-RANDOMISED NONINFERIORITY TRIAL

Berend Van Der Wilk, Ben M. Eyck, Bas P. L. Wijnhoven, Sjoerd M. Lagarde et autres

Abstract Background One of the standard treatments for patients with locally advanced oesophageal cancer is neoadjuvant chemoradiotherapy followed by oesophagectomy. Of these patients, 29% have a pathologically complete response. Active surveillance may be an alternative for patients with clinically complete response (i.e. …

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295. SAFETY OF SURVEILLANCE GASTROSCOPY AND ENDOSCOPIC ULTRASONOGRAPHY IN THE OESOPHAGUS AFTER NEOADJUVANT CHEMORADIOTHERAPY: RESULTS FROM THE SANO COHORT

S Panday, Low Kuan Yean, Manon C.W. Spaander, Tanya M. Bisseling et autres

Abstract Background An organ sparing strategy has been proposed for patients with oesophageal cancer and a clinically complete response after neoadjuvant chemoradiotherapy (nCRT). This active surveillance strategy involves (repeated) oesophagogastroduodenoscopy (OGD) with bite-on-bite biopsies and endoscopic ultrasonography (EUS). The preSANO trial and …

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Active surveillance of oesophageal cancer after response to neoadjuvant chemoradiotherapy: dysphagia is uncommon

Maria Joanna Valkema, Manon C.W. Spaander, Jurjen J. Boonstra, Jolanda M. van Dieren et autres

BACKGROUND: Active surveillance is being investigated as an alternative to standard surgery after neoadjuvant chemoradiotherapy for oesophageal cancer. It is unknown whether dysphagia persists or develops when the oesophagus is preserved after neoadjuvant chemoradiotherapy. The aim of this study was to assess …

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Editorial: thiopurines in the multidrug era—time to rescue our memories over half a century of experience. Authors' reply

Ashkan Rezazadeh Ardabili, Steven F. G. Jeuring, Zlatan Mujagic, Liekele E. Oostenbrug et autres

LINKED CONTENT This article is linked to Rezazadeh Ardabili et al papers. To view these articles, visit https://doi.org/10.1111/apt.17128 and https://doi.org/10.1111/apt.17164

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Classic drugs in the time of new drugs: real‐world, long‐term outcomes of thiopurine monotherapy in 1016 patients with inflammatory bowel disease

Ashkan Rezazadeh Ardabili, Steven F. G. Jeuring, Zlatan Mujagic, Liekele E. Oostenbrug et autres

BACKGROUND: Thiopurines remain recommended as maintenance therapy in patients with inflammatory bowel disease (IBD). Despite their widespread use, long-term effectiveness data are sparse and safety is an increasingly debated topic which thwarts proper delineation in the current IBD treatment algorithm. AIMS: To …

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Bite-on-bite biopsies for the detection of residual esophageal cancer after neoadjuvant chemoradiotherapy

Ruben D. van der Bogt, Berend J. van der Wilk, Lindsey Oudijk, Erik J. Schoon et autres

BACKGROUND: Active surveillance after neoadjuvant treatment is increasingly implemented. The success of this strategy relies on the accurate detection of residual cancer. This study aimed to assess the diagnostic value of a second (bite-on-bite) biopsy for the detection of residual esophageal cancer …

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Predictive value of endoscopic esophageal findings for residual esophageal cancer after neoadjuvant chemoradiotherapy

Ruben D. van der Bogt, Berend J. van der Wilk, Suzan Nikkessen, Kausilia Krishnawatie Krishnadath et autres

Abstract Background Endoscopic evaluation of the esophageal mucosa may play a role in an active surveillance strategy after neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer. This study investigated the yield of endoscopic findings for detection of residual disease. Methods Patients from the multicenter …

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Health outcomes of 1000 children born to mothers with inflammatory bowel disease in their first 5 years of life

Shannon L. Kanis, Sanne Modderman, Johanna C. Escher, Nicole Stephanie Erler et autres

OBJECTIVE: The aim of this study was to describe the long-term health outcomes of children born to mothers with inflammatory bowel disease (IBD) and to assess the impact of maternal IBD medication use on these outcomes. DESIGN: We performed a multicentre retrospective …

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