Predictive value of endoscopic esophageal findings for residual esophageal cancer after neoadjuvant chemoradiotherapy
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Le résumé fourni par la source
Abstract Background Endoscopic evaluation of the esophageal mucosa may play a role in an active surveillance strategy after neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer. This study investigated the yield of endoscopic findings for detection of residual disease. Methods Patients from the multicenter preSANO cohort, who underwent nCRT followed by surgery for esophageal or junctional cancer, were included. Upper endoscopy was performed 6 and 12 weeks after nCRT. Patients with residual disease at 6 weeks underwent immediate surgery. Endoscopic records were reviewed for presence of stenosis, suspicion of residual tumor, scar tissue, and ulceration. Presence and type of endoscopic findings were compared with outcome of the resection specimen. Results 118 of 156 patients (76 %) had residual disease in the resection specimen. Endoscopic suspicion of residual tumor was significantly associated with presence of residual disease. At 6 weeks, 40/112 patients with residual disease and 4/33 patients with complete response had endoscopic suspicion of residual tumor (36 % vs. 12 %; P = 0.01), while this was reported in 16/73 and 0/28 patients, respectively, at 12 weeks (22 % vs. 0 %; P < 0.01). Positive predictive value of endoscopic suspicion of residual tumor was 91 % at 6 weeks and 100 % at 12 weeks. Endoscopic findings of non-passable stenosis, passable stenosis, scar tissue, or ulceration were not associated with residual disease. Conclusions Endoscopic suspicion of residual tumor was the only endoscopic finding associated with residual disease. Based on its positive predictive value, this endoscopic finding may contribute to the diagnostic strategy used in active surveillance.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Predictive value of endoscopic esophageal findings for residual esophageal cancer after neoadjuvant chemoradiotherapy
- Date Crossref
- 02/03/2021
- Éditeur
- Georg Thieme Verlag KG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Erasmus MC Department of Gastroenterology and Hepatology pays non établi dans la noticeÉtablissement de santé
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Amsterdam UMC Location University of Amsterdam pays non établi dans la noticeÉtablissement de santé
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Radboud University Nijmegen pays non établi dans la noticeUniversité ou école supérieure
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Catharina Ziekenhuis pays non établi dans la noticeÉtablissement de santé
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Zuyderland Medisch Centrum pays non établi dans la noticeÉtablissement de santé
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Radboud University Medical Center Department of Gastroenterology and Hepatology pays non établi dans la noticeOrganisme public
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University Medical Center Utrecht Department of Gastroenterology and Hepatology pays non établi dans la noticeÉtablissement de santé
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Academic Medical Center Department of Gastroenterology and Hepatology pays non établi dans la noticeÉtablissement de santé
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Catharina Hospital Department of Gastroenterology and Hepatology pays non établi dans la noticeÉtablissement de santé
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Zuyderland Medical Center Department of Gastroenterology and Hepatology pays non établi dans la noticeÉtablissement de santé
Department of Gastroenterology and Hepatology — Erasmus MC, Amsterdam UMC Location University of Amsterdam et Radboud University Nijmegen, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.