Maria Feoktistova

Caspase-activation powers anti-Desmoglein 3-induced acantholysis in human epidermis

Morna F. Schmidt, Maria Feoktistova, Diana Panayotova‐Dimitrova, Eva Miriam Buhl et autres

Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering disease caused by circulating autoantibodies against desmoglein (Dsg) 1 and Dsg 3. Whether acantholysis in PV results exclusively from antibody binding to Dsgs or involves additional factors remains controversial. Given that Fas-Ligand (FasL), an …

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Inhibition of the JAK/STAT Signaling Pathway Suggests a Protective Effect against Acantholysis in Pemphigus

Farzan Solimani, Julia Holstein, Katharina Meier, Luz Maria Cano Rochin et autres

Pemphigus is a severe autoimmune blistering disorder of skin and mucosa, which is elicited by gG autoantibodies targeting desmosomal components such as desmoglein 3 (Dsg3). Keratinocytes lose cytoarchitectural stability and reciprocal adhesion in a process called acantholysis, which manifests as blisters and …

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Inhibition of PD-L1/PD-1 Checkpoint Increases NK Cell-Mediated Killing of Melanoma Cells in the Presence of Interferon-Beta

Lian Shen, Christina Nothbaum, Diana Panayotova‐Dimitrova, Maria Feoktistova et autres

Background/Objectives: Melanoma is a highly malignant skin tumor with poor response to conventional chemotherapeutic regimens. Melanoma cells induce cytotoxic T cell-mediated immune responses, and immunotherapy has significantly improved survival rates for patients with advanced disease. Methods: Here, we investigate NK cell-mediated melanoma …

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12 Inhibition of the JAK/STAT pathway prevents acantholysis in pemphigus

Farzan Solimani, Julia Holstein, Katharina Meier, Alberto Mesas‐Fernández et autres

Caspase-activation powers anti-Desmoglein 3-induced acantholysis in human epidermis

Amir Yazdi, Morna Friederike Schmidt, Maria Feoktistova, Diana Panayotova‐Dimitrova et autres

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Oligomerised RIPK1 is the main core component of the CD95 necrosome

Nikita V. Ivanisenko, Corinna König, Laura K. Hillert-Richter, Maria Feoktistova et autres

The necrosome is the key macromolecular signaling platform initiating necroptosis, i.e., a RIPK1/RIPK3-dependent program of cell death with an important role in the control of inflammation in multicellular organisms. However, the composition and structure of the necrosome remain incompletely understood. Here we …

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Aggressive migration in acidic pH of a glioblastoma cancer stem cell line in vitro is independent of ASIC and KCa3.1 ion channels, but involves phosphoinositide 3-kinase

Klaus-Daniel Cortés Franco, Ilka C. Brakmann, Maria Feoktistova, Diana Panayotova‐Dimitrova et autres

Abstract The microenvironment of proliferative and aggressive tumours, such as the brain tumour glioblastoma multiforme (GBM), is often acidic, hypoxic, and nutrient deficient. Acid-sensing ion channels (ASICs) are proton-sensitive Na+ channels that have been proposed to play a role in pH sensing …

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384 TNF is partially required for cell-death-triggered skin inflammation upon acute loss of cFLIP

Maria Feoktistova, R. Makarov, A.S. Yazdi, Diana Panayotova‐Dimitrova

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ESDR384 - TNF is partially required for cell-death-triggered skin inflammation upon acute loss of cFLIP

Maria Feoktistova, Roman N. Makarov, Amir Sadegh Yazdi, Diana Panayotova‐Dimitrova

ESDR030 - The Role of FasL-dependent Signaling in the Pathogenesis of Pemphigus Vulgaris

Morna Friederike Schmidt, Maria Feoktistova, Diana Panayotova‐Dimitrova, Amir Sadegh Yazdi

Pitfalls in the Application of Dispase-Based Keratinocyte Dissociation Assay for In Vitro Analysis of Pemphigus Vulgaris

Morna Friederike Schmidt, Maria Feoktistova, Diana Panayotova‐Dimitrova, Ramona A. Eichkorn et autres

Pemphigus vulgaris (PV) is a chronic, life-altering autoimmune disease due to the production of anti-desmoglein antibodies causing the loss of cell-cell adhesion in keratinocytes (acantholysis) and blister formation in both skin and mucous membranes. The dispase-based keratinocyte dissociation assay (DDA) is the …

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RIPK1 and TRADD Regulate TNF-Induced Signaling and Ripoptosome Formation

Maria Feoktistova, Román Makarov, Amir Sadegh Yazdi, Diana Panayotova‐Dimitrova

TNF is a proinflammatory cytokine that is critical for the coordination of tissue homeostasis. RIPK1 and TRADD are the main participants in the transduction of TNF signaling. However, data on the cell fate-controlling functions of both molecules are quite controversial. Here, we …

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