Valérie Choesmel-Cadamuro

Loss of PKCθ-GADD45a axis drives triple-negative breast cancer cells into p53-independent senescence

Amandine Nicolle, Ye Zhang, Valérie Choesmel-Cadamuro, Xiaobo Wang et autres

Background PKCθ is a serine/threonine kinase that is well known for its role in the immune system. However, increasing evidence implicates PKCθ in the pathology of breast cancer. PKCθ is highly expressed in triple negative breast cancer (TNBC) cells in which it …

fr (code pays fourni par la source)

PKCθ-mediated serine/threonine phosphorylations of FAK govern adhesion and protrusion dynamics within the lamellipodia of migrating breast cancer cells

Lucie Chadelle, Jiaying Liu, Valérie Choesmel-Cadamuro, Andrei V. Karginov et autres

fr, us (code pays fourni par la source)

A biochemical network controlling basal myosin oscillation

Xiang Qin, Édouard Hannezo, Thomas Mangeat, Chang Liu et autres

The actomyosin cytoskeleton, a key stress-producing unit in epithelial cells, oscillates spontaneously in a wide variety of systems. Although much of the signal cascade regulating myosin activity has been characterized, the origin of such oscillatory behavior is still unclear. Here, we show …

fr, cn, at, gb, in, us (code pays fourni par la source)

Cell-matrix adhesion and cell-cell adhesion differentially control basal myosin oscillation and Drosophila egg chamber elongation

Xiang Qin, Byung Ouk Park, Jiaying Liu, Bing Chen et autres

Pulsatile actomyosin contractility, important in tissue morphogenesis, has been studied mainly in apical but less in basal domains. Basal myosin oscillation underlying egg chamber elongation is regulated by both cell-matrix and cell-cell adhesions. However, the mechanism by which these two adhesions govern …

fr, kr, cn (code pays fourni par la source)

Non-autonomous role of Cdc42 in cell-cell communication during collective migration

Nathalie Colombié, Valérie Choesmel-Cadamuro, Jennifer Series, Grégory Emery et autres

fr, ca (code pays fourni par la source)

PKCθ-induced phosphorylations control the ability of Fra-1 to stimulate gene expression and cancer cell migration

Karine Belguise, Sara Cherradi, Awa Sarr, Florence Boissière‐Michot et autres

fr (code pays fourni par la source)

Myosin II governs collective cell migration behaviour downstream of guidance receptor signalling

Anne Combedazou, Valérie Choesmel-Cadamuro, Guillaume Gay, Jiaying Liu et autres

Border cell migration during Drosophila oogenesis is a potent model to study collective cell migration, a process involved in development and metastasis. Border cell clusters adopt two main types of behaviour during migration: linear and rotational. However, the molecular mechanism controlling the …

fr (code pays fourni par la source)

Mechanical Feedback through E-Cadherin Promotes Direction Sensing during Collective Cell Migration

Danfeng Cai, Shann-Ching Chen, Mohit Prasad, Li He et autres

us, fr (code pays fourni par la source)