Min Wang

Comprehensive genomic profiling of over 10,000 advanced solid tumors

Jean-Paul De La O, Jess Hoag, Angela K. Deem, Min Wang et autres

// Jean-Paul De La O 1 , Jess R. Hoag 1 , Angela K. Deem 1 , Min Wang 1 , Arthur Starodynov 1 , Sameer S. Udhane 1 , Janine R. LoBello 1 , Nishitha Therala 1 , David W. Hall …

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CircCCL22 Regulates CDC25A via Sponging miR-543 and Promotes Proliferation and Metastasis in Endometrial Cancer

Sichao Liu, Min Wang, Xianglin Lv, Jing Zhou et autres

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CGE23-072: The Frequency of Androgen Receptor Splice Variant 7 (AR-V7) in Solid Tumors

Zoran Gatalica, Jess Hoag, David W. Hall, Fadel S. Alyaqoub et autres

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Prevalence and genomic landscape of BRAF alterations across gastrointestinal cancers.

David Driscoll, Min Wang, Fadel S. Alyaqoub, Sameer S. Udhane et autres

806 Background: BRAF V600E mutations can lead to activation of the MEK/ERK pathway. The combination of dabrafenib plus trametinib was recently FDA-approved for use in these BRAF V600E altered unresectable or metastatic cancers. BRAF non-V600 alterations also increase phosphorylation of MEK and …

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Abstract 1263: Comprehensive genomic profiling to identify biomarkers predictive of response to immunotherapy

Pawan Noel, David W. Hall, Sameer S. Udhane, Min Wang et autres

Abstract Background: Immune-oncology (I-O) drugs show promise across multiple tumor types, and several biomarkers (BM) predict responsiveness to I-O therapy. In this descriptive study of clinical lab experience (2018-2021), we investigated the prevalence of genomic BMs associated with sensitivity and resistance to …

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Comprehensive genomic profiling to identify gene alterations in DNA repair pathway across solid tumors.

Kevin McDonnell, Gargi D. Basu, Jess W. Hoag, David W. Hall et autres

3124 Background: Deleterious events in DNA damage response (DDR) are hallmarks of cancer associated with sensitivity to PARP inhibitors (PARPi) and immune checkpoint inhibitors (CPI). This study investigated DDR pathway alterations across solid tumors. Methods: Samples were sequenced with the Oncomap ExTra …

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Comprehensive whole-exome and transcriptome profiling to identify actionable alterations associated with response to PARP inhibitors in breast cancer.

Susan M. Dombrowski, Sameer S. Udhane, Gargi D. Basu, David W. Hall et autres

1096 Background: The use of targeted therapies identified using genetic and genomic approaches is now routine in breast cancer (BC). In this clinical lab experience study the frequency of actionable somatic alterations in DNA repair pathway genes associated with the use of …

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