Zoran Gatalica

Predictive immunohistochemistry in non-small cell lung cancer – Biomarkers, companion diagnostics, and molecular testing: A narrative review

Semir Vranić, Inga Rose, Nataliya Kuzmova, Zoran Gatalica

Immunohistochemistry (IHC) is central to precision oncology in advanced non-small cell lung cancer (NSCLC), although its predictive value and the need for molecular confirmation differ across biomarkers. This narrative review aimed to summarize the clinical utility, validated assays, scoring systems, diagnostic performance, …

qa (code pays fourni par la source)

The immunotherapy breakthroughs in cervical cancer: Focus on potential biomarkers and further therapy advances

Maja Pezer Naletilić, Krešimir Tomić, Kristina Katić, Zoran Gatalica et autres

Despite the well-established role of human papillomavirus (HPV) as the primary cause of cervical cancer (CC) and the existence of an effective HPV vaccine, over half a million women are diagnosed with CC globally each year, with more than half of them …

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A novel deep learning framework for automatic scoring of PD-L1 expression in non-small cell lung cancer

Saidul Kabir, Muhammad E. H. Chowdhury, Rusab Sarmun, Semir Vranić et autres

A critical predictive marker for anti-PD-1/PD-L1 therapy is programmed death-ligand 1 (PD-L1) expression, assessed by immunohistochemistry (IHC). This paper explores a novel automated framework using deep learning to accurately evaluate PD-L1 expression from whole slide images (WSIs) of non-small cell lung cancer …

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Oncogenic fusions in renal cell carcinoma.

Gargi Dan Basu, Katon A. Kras, Cynthia A. Flannery, Anson Tharayanil et autres

475 Background: Detecting actionable or diagnostic fusions in solid tumors may significantly alter clinical decisions, including therapy selection. Some fusions have matched drugs approved for use in the patient’s cancer, or in another cancer. Others have published evidence of benefit with particular …

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Genomic profiling of biliary tract carcinomas by their location.

Zoran Gatalica, David K. Edwards, Cynthia A. Flannery, David W. Hall et autres

e16175 Background: Historically, biliary tract cancers have had a poor prognosis. Genomic profiling allows identification of alterations in genes with FDA-approved matched therapies either in these cancers ( FGFR2/3 fusions, certain IDH1 missense mutations), in all solid tumors (e.g. BRAF V600E mutations), …

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CGE23-072: The Frequency of Androgen Receptor Splice Variant 7 (AR-V7) in Solid Tumors

Zoran Gatalica, Jess R. Hoag, David W. Hall, Fadel S. Alyaqoub et autres

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The Wnt signaling pathway in gastrointestinal cancers.

Zoran Gatalica, Turgut W Dogruluk, Pawan Noel, Susan M. Dombrowski et autres

807 Background: Activation of the Wnt signaling pathway leads to increases in β-catenin levels, which subsequently increases transcription of various genes, including those involved in cell proliferation. Dysregulation of the Wnt signaling pathway has been observed in numerous gastrointestinal (GI) cancers. Here …

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