Márton Zsolt Enyedi

Germline BRCA testing in routine clinical practice: a single-center experience

Alíz Nikolényi, Ágnes Dobi, Dóra Sántha, Renáta Kószó et autres

The identification of gBRCA1/2 mutations in breast cancer patients is crucial. Successful identification of the mutations has the potential to alter disease treatment and healthcare management of patients whose relatives harbor pathogenic/likely pathogenic (P/LP) variants. In this retrospective analysis, patient- and disease-specific …

hu, us (code pays fourni par la source)

Comprehensive bulk and single-cell RNA sequencing uncovers senescence-associated biomarkers in therapeutic mesenchymal stem cells

Emese Pekker, Erda Qorri, Márton Zsolt Enyedi, Valéria Szukacsov et autres

Mesenchymal stem cells (MSCs) hold great promise in cell therapy, but their effectiveness declines with repeated cell divisions due to senescence. Canines, sharing aging characteristics with humans, serve as a valuable model to study this process in a translational context. In the …

hu, us, tw, gb, pa (code pays fourni par la source)

Comprehensive Bulk and Single-Cell RNA Sequencing Uncovers Senescence-Associated Biomarkers in Therapeutic Mesenchymal Stem Cells

Emese Pekker, Erda Qorri, Márton Zsolt Enyedi, Valéria Szukacsov et autres

Abstract Background Mesenchymal stem cells (MSCs) hold great promise in cell therapy, but their effectiveness declines with repeated cell divisions due to senescence. Canines, sharing aging characteristics with humans, serve as a valuable model to study this process in a translational context. …

us, hu, gb (code pays fourni par la source)

ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro

Lejla Daruka, Márton Simon Czikkely, Petra Szili, Zoltán Farkas et autres

Despite ongoing antibiotic development, evolution of resistance may render candidate antibiotics ineffective. Here we studied in vitro emergence of resistance to 13 antibiotics introduced after 2017 or currently in development, compared with in-use antibiotics. Laboratory evolution showed that clinically relevant resistance arises …

hu, gb (code pays fourni par la source)

ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro

Lejla Daruka, Márton Simon Czikkely, Petra Szili, Zoltán Farkas et autres

Despite ongoing antibiotic development, evolution of resistance may render candidate antibiotics ineffective. Here we studied in vitro emergence of resistance to 13 antibiotics introduced after 2017 or currently in development, compared with in-use antibiotics. Laboratory evolution showed that clinically relevant resistance arises …

Antibiotics of the future are prone to resistance in Gram-negative pathogens

Lejla Daruka, Márton Simon Czikkely, Petra Szili, Zoltán Farkas et autres

Abstract Despite the ongoing development of new antibiotics, the future evolution of bacterial resistance may render them ineffective. We demonstrate that antibiotic candidates currently under development are as prone to resistance evolution in Gram-negative pathogens as clinically employed antibiotics. Resistance generally stems …

hu, us, gb, Afrique du Sud (code pays fourni par la source)

Concordant or not? Performance and concordance rate analysis of ten prediction algorithms on clinically relevant variants from the BRCA1 and BRCA2 genes

Erda Qorri, Bertalan Takács, Márton Zsolt Enyedi, Alexandra B. Graf et autres

The widespread use of next-generation sequencing (NGS) technologies in clinical diagnostics has resulted in the identification of thousands of novel genomic variants whose clinical significance is uncertain. To address this issue, a variety of computational tools have been developed that facilitate the …

hu (code pays fourni par la source)

A Comprehensive Evaluation of the Performance of Prediction Algorithms on Clinically Relevant Missense Variants

Erda Qorri, Bertalan Takács, Alexandra B. Graf, Márton Zsolt Enyedi et autres

The rapid integration of genomic technologies in clinical diagnostics has resulted in the detection of a multitude of missense variants whose clinical significance is often unknown. As a result, a plethora of computational tools have been developed to facilitate variant interpretation. However, …

hu (code pays fourni par la source)

A Comprehensive Evaluation of the Performance of Prediction Algorithms on Clinically Relevant Missense Variants

Erda Qorri, Bertalan Takács, Alexandra B. Graf, Márton Zsolt Enyedi et autres

Benchmarking Datasets.

hu (code pays fourni par la source)

BC-Monitor: Towards a Routinely Accessible Circulating Tumor DNA-Based Tool for Real-Time Monitoring Breast Cancer Progression and Treatment Effectiveness

Katalin Priskin, Sára Pólya, Lajos Pintér, Gábor Jaksa et autres

Circulating tumor DNA (ctDNA) is increasingly employed in the screening, follow-up, and monitoring of the continuously evolving tumor; however, most ctDNA assays validated for clinical use cannot maintain the right balance between sensitivity, coverage, sample requirements, time, and cost. Here, we report …

hu (code pays fourni par la source)

The Combination of Single-Cell and Next-Generation Sequencing Can Reveal Mosaicism for BRCA2 Mutations and the Fine Molecular Details of Tumorigenesis

Alexandra Gráf, Márton Zsolt Enyedi, Lajos Pintér, Éva Kriston-Pál et autres

Germline mutations in the BRCA1 and BRCA2 genes are responsible for hereditary breast and ovarian cancer syndrome. Germline and somatic BRCA1/2 mutations may define therapeutic targets and refine cancer treatment options. However, routine BRCA diagnostic approaches cannot reveal the exact time and …

hu, fi (code pays fourni par la source)

Intelligent image-based in situ single-cell isolation

Csilla Braskó, Kevin Smith, Csaba Molnár, Nóra Faragó et autres

Quantifying heterogeneities within cell populations is important for many fields including cancer research and neurobiology; however, techniques to isolate individual cells are limited. Here, we describe a high-throughput, non-disruptive, and cost-effective isolation method that is capable of capturing individually targeted cells using …

hu, se, fi (code pays fourni par la source)