Accès ouvert
2022
article
OpenAlex
Michelle Ghert, Patricia Schneider, Victoria Giglio, Andrew Duong et autres
IMPORTANCE: The use of perioperative, prophylactic, intravenous antibiotics is standard practice to reduce the risk of surgical site infection after oncologic resection and complex endoprosthetic reconstruction for lower extremity bone tumors. However, evidence guiding the duration of prophylactic treatment remains limited. OBJECTIVE: …
ca, es, us
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Raymond T. Kraker, David K. Wallace, Roy W. Beck, Christina Saunders et autres
This study determines which of 8 doses of bevacizumab are effective in treating severe retinopathy of prematurity to carry forward to a large-scale randomized clinical trial.
us
(code pays fourni par la source)
Accès ouvert
2013
article
OpenAlex
John T. Kissel, Bakri Elsheikh, Wendy King, Miriam Freimer et autres
INTRODUCTION: An open-label trial suggested that valproic acid (VPA) improved strength in adults with spinal muscular atrophy (SMA). We report a 12-month, double-blind, cross-over study of VPA in ambulatory SMA adults. METHODS: There were 33 subjects, aged 20–55 years, included in this …
us, ca
(code pays fourni par la source)
Accès ouvert
2011
article
OpenAlex
John T. Kissel, Charles Scott, Sandra P. Reyna, Thomas O. Crawford et autres
BACKGROUND: Multiple lines of evidence have suggested that valproic acid (VPA) might benefit patients with spinal muscular atrophy (SMA). The SMA CARNIVAL TRIAL was a two part prospective trial to evaluate oral VPA and L-carnitine in SMA children. Part 1 targeted non-ambulatory …
us, ca
(code pays fourni par la source)
Accès ouvert
2010
article
OpenAlex
Kathryn J. Swoboda, Charles Scott, Thomas O. Crawford, Louise R. Simard et autres
BACKGROUND: Valproic acid (VPA) has demonstrated potential as a therapeutic candidate for spinal muscular atrophy (SMA) in vitro and in vivo. METHODS: Two cohorts of subjects were enrolled in the SMA CARNIVAL TRIAL, a non-ambulatory group of "sitters" (cohort 1) and an …
us, ca
(code pays fourni par la source)
Accès ouvert
2009
article
OpenAlex
Kathryn J. Swoboda, Charles Scott, Sandra P. Reyna, Thomas W. Prior et autres
UNLABELLED: Preliminary in vitro and in vivo studies with valproic acid (VPA) in cell lines and patients with spinal muscular atrophy (SMA) demonstrate increased expression of SMN, supporting the possibility of therapeutic benefit. We performed an open label trial of VPA in …
us, ca
(code pays fourni par la source)
1988
article
OpenAlex
Lawrence R. Murphy, Susan Sorenson
Abstract A quasi‐experiment was used to compare employee behaviors before and after stress management training. Organizational records on employee absenteeism, performance ratings, equipment accidents, and work injuries were obtained for highway maintenance workers who received biofeedback (BIO=21) or muscle relaxation (MR=16) training. …
us
(code pays fourni par la source)