Adam G. Golden

Re: AI and Technology in Geriatrics: A New Chapter in JAGS

Adam G. Golden, Chen Chen, Andrew Borkowski

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The inclusion and selection of underserved participants for interventional microbiota trials involving cognitively impaired older adults

Cynthia White Williams, Adam G. Golden, Hariom Yadav, Michal M Masternak

BACKGROUND: Gut microbiota is crucial in nutrient extraction, metabolism, cognition, and immune function. Consequently, the increasing number of microbiome studies aims to link specific bacteria, fungi, and viruses with various cognitive disease outcomes. Unfortunately, clinical studies often exclude many older adults with …

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Inflammation‐Linked Microbiome Alterations Associated with Cognitive Impairment in Older Adults: Insights from the MiaGB Consortium

Sidharth P. Mishra, Shalini Jain, Dhananjay Yadav, Lauren Buddendorff et autres

Abstract Background The increasing prevalence of cognitive decline and dementia poses a significant public health challenge for older adults, and effective preventive and therapeutic strategies remain elusive. This is largely due to an incomplete understanding of the precise etiology and contributing factors …

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Gut microbiome signatures predict cognitive impairment in older cancer survivors

Brandi Miller, Jayden A. Haggler, Diptaraj Chaudhari, Rohit Shukla et autres

Cancer treatments are improving, and the population of cancer survivors is steadily increasing. However, many survivors experience long-term side effects, including chemobrain and other age-related geriatric disorders like cognitive impairment (CI), severely impacting their quality of life. Emerging studies suggest that the …

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Activity Engagement Across Stages of Cognitive Health

Cynthia Williams, Corinne Labyak, Andrea Y. Arikawa, Anna Watermann et autres

Objective: This study aims to examine activity engagement across stages of cognitive health among older adults. Methods: We used a cross-sectional study analysis of baseline data collected as part of the prospective Microbiome in Aging of Gut and Brain (MiaGB) longitudinal study; …

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Cognitive Impairment Is Associated with Alterations in Diet Quality and Inflammatory Biomarkers in Older Adults: A Cross-Sectional Analysis of Data Collected from the Microbiome in Aging Gut and Brain (MiaGB) Consortium Cohort

Andrea Y. Arikawa, A.J. Waterman, Sidharth P. Mishra, Corinne Labyak et autres

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Associations of Cognitive Status, Sex and Diet in Older Adults: A Cross-Sectional Analysis of the Microbiome in Aging Gut and Brain (MiaGB) Study

A.J. Waterman, Payton Engelken, Andrea Y. Arikawa, Adam G. Golden et autres

every 4-week.Blood samples were collected before and after intervention and blood levels of amyloid beta (Aβ)40, Aβ42, gamma-aminobutyric acid and serotonin were measured.Results: There were no differences in baseline cognitive function and mental health status, levels of cognitive functionrelated biomarkers and dietary …

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The selection of participants for interventional microbiota trials involving cognitively impaired older adults

Adam G. Golden, Cynthia Williams, Hariom Yadav, Michał M. Masternak et autres

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Abnormalities in gut virome signatures linked with cognitive impairment in older adults

Adewale Segun James, Noorul Ain Adil, Dayna Goltz, Divyani Tangudu et autres

Multiple emerging lines of evidence indicate that the microbiome contributes to aging and cognitive health. However, the roles of distinct microbial components, such as viruses (virome) and their interactions with bacteria (bacteriome), as well as their metabolic pathways (metabolome) in relation to …

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THEORETICAL FRAMEWORK FOR AN ARTIFICIAL INTELLIGENCE–BASED COMPREHENSIVE GERIATRIC ASSESSMENT

Adam G. Golden

Abstract Comprehensive Geriatric Assessment (CGA) is a process where healthcare professionals evaluate and develop a management strategy for older adults who may have multiple multifactorial illnesses and geriatric syndromes. CGA has traditionally been a labor-intensive process that assesses many factors at a …

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UNIQUE MICROBIOME-PROTEOME SIGNATURES OF SALIVA IN PREDICTION OF COGNITIVE DECLINE IN OLDER ADULTS OF MIAGB COHORT

Diptaraj Chaudhari, Shalini Jain, Corinne Labyak, Adam G. Golden et autres

Abstract The prevalence of age-related cognitive decline and dementia is increasing in older adults, with limited prevention and therapeutic options, increasing tremendous burden on healthcare system. Alzheimer’s disease (AD) is the most common age-related cognitive disorder, for which no treatment is available …

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Unique trans-kingdom microbiome structural and functional signatures predict cognitive decline in older adults

Diptaraj Chaudhari, Shalini Jain, Vinod K. Yata, Sidharth P. Mishra et autres

The prevalence of age-related cognitive disorders/dementia is increasing, and effective prevention and treatment interventions are lacking due to an incomplete understanding of aging neuropathophysiology. Emerging evidence suggests that abnormalities in gut microbiome are linked with age-related cognitive decline and getting acceptance as …

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