Deeksha Kaloni

Genome-wide in vivo CRISPR screens identify GATOR1 complex as a tumor suppressor in Myc-driven lymphoma

Margaret A. Potts, Shinsuke Mizutani, Yexuan Deng, Srimayee Vaidyanathan et autres

Identifying tumor suppressor genes is predicted to inform on the development of novel strategies for cancer therapy. To identify new lymphoma driving processes that cooperate with oncogenic MYC, which is abnormally highly expressed in ~70% of human cancers, we use a genome-wide …

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Understanding the regulation of the BH3-only proteins PUMA and BIM by TRP53 dependent and TRP53 independent processes to enhance the efficacy of BH3-mimetic drugs and other anti-cancer agents in cancer therapy

Deeksha Kaloni

© 2025 Deeksha Kaloni

Mouse models to investigate in situ cell fate decisions induced by p53

Elizabeth Lieschke, Annabella Thomas, Andrew J. Kueh, Georgia K. Atkin‐Smith et autres

Investigating how transcription factors control complex cellular processes requires tools that enable responses to be visualised at the single-cell level and their cell fate to be followed over time. For example, the tumour suppressor p53 (also called TP53 in humans and TRP53 …

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Supplementary Data Figure S24 from Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells

Zilu Wang, Matteo Burigotto, Sabrina Ghetti, François Vaillant et autres

Supplementary Figure S24 showing that removal of mutant TP53 does not impair the in vitro growth of human colon cancer derived organoids

Supplementary Data Figure S3 from Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells

Zilu Wang, Matteo Burigotto, Sabrina Ghetti, François Vaillant et autres

Supplementary Figure S3 showing that removal of mutant TP53 does not impair the ability of diverse human cancer cell lines to adapt to conditions of stress

Data from Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells

Zilu Wang, Matteo Burigotto, Sabrina Ghetti, François Vaillant et autres

Abstract Mutations in the tumor suppressor TP53 cause cancer and impart poor chemotherapeutic responses, reportedly through loss-of-function, dominant-negative effects and gain-of-function (GOF) activities. The relative contributions of these attributes is unknown. We found that removal of 12 different TP53 mutants with reported …

Supplementary Data Figure S13 from Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells

Zilu Wang, Matteo Burigotto, Sabrina Ghetti, François Vaillant et autres

Supplementary Figure S13 showing that mutant TP53 deficient human cancer cell lines retain the machinery to respond to the activation of wt TP53

Supplementary Data Figure S11 from Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells

Zilu Wang, Matteo Burigotto, Sabrina Ghetti, François Vaillant et autres

Supplementary Figure S11 showing that removal of mutant TP53 does not cause a competitive growth disadvantage in diverse human cancer cell lines in culture

Supplementary Data Figure S14 from Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells

Zilu Wang, Matteo Burigotto, Sabrina Ghetti, François Vaillant et autres

Supplementary Figure S14 showing that CRISPR-HDR mediated conversion of mutant TP53 into wt TP53 causes a growth disadvantage in human cancer cell lines

Data from Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells

Zilu Wang, Matteo Burigotto, Sabrina Ghetti, François Vaillant et autres

Abstract Mutations in the tumor suppressor TP53 cause cancer and impart poor chemotherapeutic responses, reportedly through loss-of-function, dominant-negative effects and gain-of-function (GOF) activities. The relative contributions of these attributes is unknown. We found that removal of 12 different TP53 mutants with reported …

Supplementary Data Table S6 from Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells

Zilu Wang, Matteo Burigotto, Sabrina Ghetti, François Vaillant et autres

Supplementary Table S6 showing the impact of removal of mutant BRAF in human cancer cell lines in vitro by CRISPR/Cas9 by mining the DepMap database

Supplementary Data Figure S10 from Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells

Zilu Wang, Matteo Burigotto, Sabrina Ghetti, François Vaillant et autres

Supplementary Figure S10 showing that complete removal of mutant TP53 in MDA-MB-468 cells does not impair survival and proliferation in culture