Grazia Pavia

Human papillomavirus (HPV) Vaccination programmes across European countries: time-harmonized coverage among adolescent females, socioeconomic predictors, and impact on public interest

Grazia Pavia, Angela Quirino, Nadia Marascio, Francesca Licata et autres

BACKGROUND: Human papillomavirus (HPV) vaccination represents a cornerstone of cervical cancer prevention and is essential to achieving the WHO elimination targets in Europe. The study aimed to assess HPV vaccination coverage trends among adolescent females across Europe, identify key predictors of uptake, …

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Integrated Computational and Experimental Discovery of a Selective Indole-Based Hit Targeting Leishmania infantum Trypanothione Reductase through a Dual-Site Binding Mode

Antonio Curcio, Grazia Pavia, Roberta Rocca, Vittorio Brufani et autres

This repository contains the molecular dynamics simulation files, dataset preparation scripts, NMR and HPLC analyses of CNP0312189, and raw analysis data supporting the results reported in the accompanying manuscript.

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Integrated Computational and Experimental Discovery of a Selective Indole-Based Hit Targeting Leishmania infantum Trypanothione Reductase through a Dual-Site Binding Mode

Antonio Curcio, Grazia Pavia, Roberta Rocca, Vittorio Brufani et autres

This repository contains the molecular dynamics simulation files, dataset preparation scripts, NMR and HPLC analyses of CNP0312189, and raw analysis data supporting the results reported in the accompanying manuscript.

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A Selective and Safe Indole-Based Lead Compound Targeting LiTR for Anti-Leishmania Therapy: A One Health–Driven Discovery

Antonio Curcio, Grazia Pavia, Roberta Rocca, Vittorio Brufani et autres

This repository contains the molecular dynamics simulation files, dataset preparation scripts, and raw analysis data supporting the results reported in the accompanying JCIM manuscript.

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Genomic Insights into Carbapenem-Resistant Pseudomonas aeruginosa (CRPA): Resistome and Virulome Analysis Beyond Carbapenemases

Marta Pantanella, Grazia Pavia, Nadia Marascio, Chiara Mazzei et autres

Background: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) has been added to the World Health Organization’s list as a high-priority pathogen for which new antibiotics are urgently needed. Herein, we investigated the association between resistance/virulence genes and high-risk CRPA clinical isolates by whole genome sequencing …

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Beat the clock: One-hour diagnostics of emerging viral threats using fast molecular approaches

Grazia Pavia, Emanuele Giorgio, Nadia Marascio, Giorgio Settimo Barreca et autres

BACKGROUND: Emerging viral infections pose significant challenges for clinical management and public health, particularly in non-endemic settings. Rapid and accurate diagnostics are essential to guide therapy, implement infection control measures, and support epidemiological surveillance. Traditional methods, including viral culture and early serology, …

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Perioperative Blood Biomarkers of Infectious and Non-Infectious Postoperative Pulmonary Complications: A Narrative Review

Simona Gigliotti, Giuseppe Guerriero, Giuseppe Mazza, Eugenio Garofalo et autres

Background/Objectives: Postoperative pulmonary complications (PPCs) remain frequent and increase morbidity, mortality, and resource use. Preoperative risk scores (ARISCAT, NSQIP-derived calculators) use mostly static variables and may miss the dynamic perioperative host response preceding respiratory deterioration or infection. We address the gap in …

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could it represent an evolutionary balance and a vaccine target?

Francesca Divenuto, Simona Gigliotti, Grazia Pavia, Vitale Fabrizio et autres

Concomitant immunity (CI) can be viewed as an example of coevolution between the microorganisms and their long-lived hosts. Such an ecological trade-off may be advantageous to both the microbe and the host, as it allows protozoa and helminths to maintain their genetic …

Concomitant immunity in persistent Leishmania infections: could it represent an evolutionary balance and a vaccine target?

Francesca Divenuto, Simona Gigliotti, Grazia Pavia, Fabrizio Vitale et autres

Abstract Concomitant immunity (CI) can be viewed as an example of coevolution between the microorganisms and their long-lived hosts. Such an ecological trade-off may be advantageous to both the microbe and the host, as it allows protozoa and helminths to maintain their …

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Human Cytomegalovirus infection in the era of vaccine development: case series of immunocompromised patients

Nadia Marascio, Grazia Pavia, Chiara Mazzei, Marta Pantanella et autres

Introduction Human Cytomegalovirus (CMV) infection represents a significant health burden, particularly for immunocompromised patients, including solid-organ transplant (SOT) recipients and people living with human immunodeficiency virus (PLWH). Despite the availability of antiviral prophylaxis and treatment, prolonged therapy can lead to viral drug …

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Calprotectin, Azurocidin, and Interleukin-8: Neutrophil Signatures with Diagnostic and Prognostic Value in Sepsis

Simona Gigliotti, Michele Manno, Francesca Divenuto, Grazia Pavia et autres

Background: Sepsis remains a major cause of morbidity and mortality in both developed and limited-resource countries. Despite over a century of research, accurate biomarkers for reliable diagnosis and prognosis in critically ill patients have yet to be established. Methods: This multicenter retrospective …

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Hepatitis C (HCV) and Hepatitis Delta (HDV) Viruses in a Teaching Hospital in Southern Italy: What Is the Epidemiological Situation in the Era of New Drugs?

Nadia Marascio, Grazia Pavia, Chiara Mazzei, Michele Manno et autres

If the number of viral hepatitis infections is to be decreased worldwide, and the World Health Organization (WHO) elimination targets are to be achieved by 2030, this requires determining the burden of infection according to the WHO's test-and-treat approach. In 2014, the …

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