Max Zimmermann

Genetically-encoded gas vesicles bridge mesoscopic ultrasound and cellular-resolution microscopy

Bettina Weigelin, Martina Giampetraglia, Lucas Freidel, Marjorie T. Buss et autres

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MRI for tissue classification of subcutaneous colon cancer using oxygen enhanced (OE), dynamic contrast enhanced (DCE) MRI and [18F]FAZA PET

Marta Vuozzo, Max Zimmermann, Mystele Tendonge, Petros Martirosian et autres

Solid tumors exhibit intratumoral heterogeneity, which is related to therapy efficacy. Since biopsies represent a small part of the tumor, multimodal imaging techniques provide panoptic cancer characterization. We developed an acquisition and analysis protocol based on multiparametric MRI to classify and provide …

Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids

Jean-Philippe Auger, Max Zimmermann, Maria M. Faas, Ulrich Stifel et autres

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Abstract 4158: Non-invasive mapping of acidosis and extracellular lactosis for assessing tumor invasion in vivo

Anaïs Choffart, Remy Chiaffarelli, Max Zimmermann, Laura Kuebler et autres

Abstract Tumor cells typically display a hyperglycolytic metabolic phenotype characterized by increased lactate production, known as the Warburg effect. This drift in oxidative metabolism often results in a more acidic microenvironment. This adverse microenvironment represents a unique metabolic signature in cancer cells …

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Supplementary Materials from Tissue Hypoxia and Alterations in Microvascular Architecture Predict Glioblastoma Recurrence in Humans

Andreas Stadlbauer, Thomas Mehari Kinfe, Ilker Yasin Eyüpoglu, Max Zimmermann et autres

Supplementary Methods, Figures, and Tables

Data from Tissue Hypoxia and Alterations in Microvascular Architecture Predict Glioblastoma Recurrence in Humans

Andreas Stadlbauer, Thomas Mehari Kinfe, Ilker Yasin Eyüpoglu, Max Zimmermann et autres

AbstractPurpose: Insufficient control of infiltrative glioblastoma (GBM) cells is a major cause of treatment failure and tumor recurrence. Hence, detailed insights into pathophysiologic changes that precede GBM recurrence are needed to develop more precise neuroimaging modalities for tailored diagnostic monitoring and therapeutic …

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Data from Tissue Hypoxia and Alterations in Microvascular Architecture Predict Glioblastoma Recurrence in Humans

Andreas Stadlbauer, Thomas Mehari Kinfe, Ilker Yasin Eyüpoglu, Max Zimmermann et autres

AbstractPurpose: Insufficient control of infiltrative glioblastoma (GBM) cells is a major cause of treatment failure and tumor recurrence. Hence, detailed insights into pathophysiologic changes that precede GBM recurrence are needed to develop more precise neuroimaging modalities for tailored diagnostic monitoring and therapeutic …

Supplementary Materials from Tissue Hypoxia and Alterations in Microvascular Architecture Predict Glioblastoma Recurrence in Humans

Andreas Stadlbauer, Thomas Mehari Kinfe, Ilker Yasin Eyüpoglu, Max Zimmermann et autres

Supplementary Methods, Figures, and Tables

Metabolic Tumor Microenvironment Characterization of Contrast Enhancing Brain Tumors Using Physiologic MRI

Andreas Stadlbauer, Franz Marhold, Stefan Oberndorfer, Gertraud Heinz‐Peer et autres

The tumor microenvironment is a critical regulator of cancer development and progression as well as treatment response and resistance in brain neoplasms. The available techniques for investigation, however, are not well suited for noninvasive in vivo characterization in humans. A total of …

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Physiological MRI of microvascular architecture, neovascularization activity, and oxygen metabolism facilitate early recurrence detection in patients with IDH-mutant WHO grade 3 glioma

Andreas Stadlbauer, Gertraud Heinz‐Peer, Stefan Oberndorfer, Max Zimmermann et autres

Abstract Purpose This study aimed to determine the diagnostic performance of physiological MRI biomarkers including microvascular perfusion and architecture, neovascularization activity, tissue oxygen metabolism, and tension for recurrence detection of IDH-mutant WHO grade 3 glioma. Methods Sixty patients with IDH-mutant WHO grade …

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Physiological MRI Biomarkers in the Differentiation Between Glioblastomas and Solitary Brain Metastases

Elisabeth Heynold, Max Zimmermann, Nirjhar Hore, Michael Buchfelder et autres

PURPOSE: Glioblastomas (GB) and solitary brain metastases (BM) are the most common brain tumors in adults. GB and BM may appear similar in conventional magnetic resonance imaging (cMRI). Their management strategies, however, are quite different with significant consequences on clinical outcome. The …

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Hypoxia and Microvascular Alterations Are Early Predictors of IDH-Mutated Anaplastic Glioma Recurrence

Andreas Stadlbauer, Stefan Oberndorfer, Gertraud Heinz‐Peer, Max Zimmermann et autres

Anaplastic gliomas (AG) represents aggressive brain tumors that often affect young adults. Although isocitrate-dehydrogenase (IDH) gene mutation has been identified as a more favorable prognostic factor, most IDH-mutated AG patients are confronted with tumor recurrence. Hence, increased knowledge about pathophysiological precursors of …

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