Metabolic Tumor Microenvironment Characterization of Contrast Enhancing Brain Tumors Using Physiologic MRI
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Le résumé fourni par la source
The tumor microenvironment is a critical regulator of cancer development and progression as well as treatment response and resistance in brain neoplasms. The available techniques for investigation, however, are not well suited for noninvasive in vivo characterization in humans. A total of 120 patients (59 females; 61 males) with newly diagnosed contrast-enhancing brain tumors (64 glioblastoma, 20 brain metastases, 15 primary central nervous system (CNS) lymphomas (PCNSLs), and 21 meningiomas) were examined with a previously established physiological MRI protocol including quantitative blood-oxygen-level-dependent imaging and vascular architecture mapping. Six MRI biomarker maps for oxygen metabolism and neovascularization were fused for classification of five different tumor microenvironments: glycolysis, oxidative phosphorylation (OxPhos), hypoxia with/without neovascularization, and necrosis. Glioblastoma showed the highest metabolic heterogeneity followed by brain metastasis with a glycolysis-to-OxPhos ratio of approximately 2:1 in both tumor entities. In addition, glioblastoma revealed a significant higher percentage of hypoxia (24%) compared to all three other brain tumor entities: brain metastasis (7%; p < 0.001), PCNSL (8%; p = 0.001), and meningioma (8%; p = 0.003). A more aggressive biological brain tumor behavior was associated with a higher percentage of hypoxia and necrosis and a lower percentage of remaining vital tumor tissue and aerobic glycolysis. The proportion of oxidative phosphorylation, however, was rather similar (17–26%) for all four brain tumor entities. Tumor microenvironment (TME) mapping provides insights into neurobiological differences of contrast-enhancing brain tumors and deserves further clinical cancer research attention. Although there is a long roadmap ahead, TME mapping may become useful in order to develop new diagnostic and therapeutic approaches.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Metabolic Tumor Microenvironment Characterization of Contrast Enhancing Brain Tumors Using Physiologic MRI
- Date Crossref
- 29/09/2021
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Friedrich-Alexander-Universität Erlangen-Nürnberg pays non établi dans la noticeUniversité ou école supérieure
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Karl Landsteiner University of Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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University of Tübingen Department of Preclinical Imaging and Radiopharmacy pays non établi dans la noticeUniversité ou école supérieure
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Friedrich-Alexander University Erlangen-Nürnberg Department of Neurosurgery pays non établi dans la noticeUniversité ou école supérieure
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University Clinic St. Pölten Institute of Medical Radiology pays non établi dans la noticeUniversité ou école supérieure
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University Clinic of St. Pölten Department of Neurosurgery pays non établi dans la noticeUniversité ou école supérieure
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Friedrich-Alexander University (FAU) Erlangen-Nürnberg Division of Functional Neurosurgery and Stereotaxy pays non établi dans la noticeUniversité ou école supérieure
Friedrich-Alexander-Universität Erlangen-Nürnberg, Karl Landsteiner University of Health Sciences et Department of Preclinical Imaging and Radiopharmacy — University of Tübingen, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.