O.T. Raitakari

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

A. Uitterlinden, Massimiliano Cocca, Maria Pina Concas, T.V. Duong et autres

The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, …

Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Ozren Polašek, Christie M. Ballantyne, Shi‐Ming Lin, Hua Tang et autres

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an …

Meta-analysis of exome array data identifies six novel genetic loci for lung function

David J. Porteous, André G. Uitterlinden, George O'connor, Jonathan Marten et autres

Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of exome array data and three lung function measures: forced …

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

Frits R. Rosendaal, Hugues Aschard, Kurt K. Lohman, Jiang He et autres

Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci …

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

Ken Rice, Lisa W. Martin, Chen-Huan Yu, Pamela J. Schreiner et autres

Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In …

The Polygenic and Monogenic Basis of Blood Traits and Diseases

Niki Dimou, O. Stegle, A. Greinacher, S.B. Watt et autres

Blood cells play essential roles in human health, underpinning physiological processes such as immunity, oxygen transport, and clotting, which when perturbed cause a significant global health burden. Here we integrate data from UK Biobank and a large-scale international collaborative effort, including data …

us (code pays fourni par la source)

Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

M.-H. Chen, K.S. Lo, V. Laplante, Y. Li et autres

Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EUR individuals, we identified 5,552 trait-variant associations at p < 5 × 10−9, including 71 novel …

us (code pays fourni par la source)