Accès ouvert déclaré
2024
article
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
Ozren Polašek, Christie M. Ballantyne, Shi‐Ming Lin, Hua Tang, C. Charles Gu, A. Mahajan, Arthur A. Campbell, Frida Renström, Anna Luzzi, Stephen B. Kritchevsky, K. Liu, Tin Aung, Bernard Prins, Xiuqing Guo, Lili Milani, Wanqing Wen, K.D. Taylor, Tin Louie, Saima Afaq, E.P. Bottinger, S.S. Rich, D.E. Arking, Craig Johnson, Xuan Deng, Colin A. McKenzie, A. Stancáková, A.P. Morris, Adebowale Adeyemo, T.O. Kilpeläinen, J. Kuusisto, D.I. Chasman, M. Ghanbari, X. Chen, Weidong Zhang, L.-P. Lyytikäinen, Ilaria Gandin, Xueling Sim, P.S. de Vries, E. Evangelou, Jennifer A. Smith, Jinghua Zhao, K. Schwander, K.-H. Lin, Maik Pietzner, Marie Loh, Michiaki Kubo, Jian’an Luan, José Eduardo Krieger, A.E. Justice, Ivana Kolčić, C. Li, H. J. de Silva, Lu Yu, Yik Ying Teo, Yi-Jen Hung, Karin Leander, Ilja M. Nolte, C.O. Schmidt, Jianjun Liu, Harold Snieder, Nicole Schupf, O.T. Raitakari, B. Kühnel, Fang‐Chi Hsu, H.M. Stringham, Matthias Nauck, Jeanette Baker, Sina A. Gharib, Guimin Chen, Lynda M. Rose, Fernando Pires Hartwig, E. Lim, He Gao, Michael A. Nalls, Rajkumar Dorajoo, Wensheng Zhao, Yaping Xiang, K.L. Mohlke, C.-Y. Cheng, Mathilde Boissel, Traci M. Bartz, Jost B. Jonas, Nana Matoba, Cristy Lewis, Nicholas Tan, F.R. Rosendaal, Tuomo Rankinen, A. Metspalu, Konstantin Strauch, A.R.V.R. Horimoto, N.D. Palmer, P.A. Peyser, Kurt K. Lohman, Alison D. Murray, Mario Sims, Marzyeh Amini, R. Graham Barr, Peter J. van der Most, C. Kooperberg, Mickaël Canouil, Jeffery R. O’Connell, Reedik Mägi, B.E. Cade, Terrence Forrester, Christopher P. Nelson, Najaf Amin, J.S Floyd, Carl D. Langefeld, Yongjun Sung, Lawrence F. Bielak, Zorayr Arzumanyan, B. Gigante, Qing Duan, Maris Alver, Nita G. Forouhi, James E. Hixson, Matthew Brown, J.F. Chai, Yufang Shi, Alison R. Bentley, Neil R Poulter, Jessica D. Faul, Anuj Goel, Lisa R. Yanek, Roby Joehanes, M.A. Richard, Jingjing Liang, Anuradhani Kasturiratne, Ruben N. Eppinga, Chiea Chuen Khor, Tibor V. Varga, Ιωάννα Ντάλλα, L.J. Launer, R.A. Scott, Hans J. Grabe, Muhammad Riaz, William R. Scott, A.T. Kraja, Tamar Sofer, Thomas W. Winkler, E. Boerwinkle, M.F. Feitosa, T. Meitinger, Y.-D.I. Chen, Bamidele O. Tayo, Antonietta Robino, Michael R. Brown, Ani Manichaikul, Igor Rudan, Yanick Hagemeijer, Jasmin Divers, Uli Broeckel, M.A. Said, J.E. Huffman, Yechiel Friedlander, Yajuan Wang, Shelley Harris, Jennifer G. Robinson, Tomohiro Katsuya, Dina Vojinović, Yang Jia, Pamela J. Schreiner, Tzung‐Dau Wang, Chew‐Kiat Heng, A.U. Jackson, Claudia Langenberg, Jian Ding, Chuan Gao, Miao He, John M. Starr, Woon‐Puay Koh, M. Arfan Ikram, Charles B. Eaton, Nancy L. Pedersen, F. Takeuchi, Peter Sever, Raymond Noordam, S.K. Musani, L. de las Fuentes, Erin B. Ware, Pirjo Komulainen, Annette Peters, Maria Pina Concas, C.-T. Liu, George Papanicolau, Yukihide Momozawa, Salman M. Tajuddin, K. Christensen, Sami Heikkinen, Stephen Sidney, Hugues Aschard, Y. Li, A.P. Reiner, K.E. North, Benjamin Lehne, T.B. Harris, Albert V. Smith, Yuri Milaneschi, Treva Rice, F. Giulianini, J. M. C. Connell, Ayo P. Doumatey, Mariaelisa Graff, Makoto Hirata, Alisa K. Manning, Timo A. Lakka
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Résumé fourni par la source
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
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Sujets associés
Genetic Associations and Epidemiology