Xuejiao Hong

Targeting CDK8 dually enhances paclitaxel antitumor efficacy and alleviates chemotherapy-induced peripheral neuropathy in breast cancer

Xuejiao Hong, Dong Fang

Background Paclitaxel-based chemotherapy remains a mainstay for breast cancer treatment, yet its efficacy is often limited by drug resistance and dose-limiting peripheral neuropathy. This study aimed to investigate whether CDK8 could serve as a dual target for enhancing the antitumor efficacy of …

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Prevalence, risk factors, and prediction of inappropriate use of non-vitamin K antagonist oral anticoagulants in elderly Chinese patients with atrial fibrillation: A study protocol

Shujuan Zhao, Bo-Ya Chen, Xuejiao Hong, Yinping Liu et autres

Background: Atrial fibrillation (AF) is an arrhythmia that is prevalent globally, and its incidence grows exponentially with aging. Non-vitamin K antagonist oral anticoagulants (NOACs) have been developed in recent years, and it challenges the supremacy of warfarin for thromboembolism prophylaxis in AF. …

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Antithrombotic Management for Atrial Fibrillation Patients Undergoing Percutaneous Coronary Intervention or With Acute Coronary Syndrome: An Evidence-Based Update

Shujuan Zhao, Xuejiao Hong, Haixia Cai, Mingzhou Liu et autres

Combined antithrombotic regimens for atrial fibrillation (AF) patients with coronary artery disease, particularly for those who have acute coronary syndrome (ACS) and/or are undergoing percutaneous coronary intervention (PCI), presents a great challenge in the real-world clinical scenario. Conventionally, a triple antithrombotic therapy …

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Appropriate Dosing Regimens of Non-Vitamin K Antagonist Oral Anticoagulants for Treatment of Patients With Non-Valvular Atrial Fibrillation: An Evidence-Based Consideration

Shujuan Zhao, Xuejiao Hong, Jingjing Cao, Haixia Cai et autres

Patients with non-valvular atrial fibrillation (NVAF) exhibit a high risk of stroke, which is associated with high mortality. Thus, stroke prevention is crucial for the overall management of NVAF. Two categories of drugs, vitamin K antagonist warfarin and non-vitamin K antagonist oral …

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Circular RNA expression profile of Alzheimer’s disease and its clinical significance as biomarkers for the disease risk and progression

Yuanlong Li, Hua Fan, Jun Sun, Ming Ni et autres

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Visible-light-mediated photocatalytic cross-coupling of acetenyl ketones with benzyl trifluoroborate

Lingchun Zhang, Yanle Chu, Peizhi Ma, Shujuan Zhao et autres

In this report, we describe a simple visible light-triggered Barbier-type reaction by employing acetenyl ketones with benzyl trifluoroborates. Through a radical-radical cross-coupling process, this photocatalytic protocol furnished a wide range of tertiary propargyl alcohols. Mechanistic investigation indicated that proton-coupled electron transfer (PCET) …

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Current Evidence for Pharmacologic Reversal Using Direct Oral Anticoagulants: What’s New?

Shujuan Zhao, Xuejiao Hong, Jingjing Cao, Jing Zhang et autres

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Fidgetin-like 1 is a ciliogenesis-inhibitory centrosome protein

Xiaoyu Zhao, Miaomiao Jin, Mengzhu Wang, Lili Sun et autres

Fidgetin-like 1 (FIGL-1) is a homolog of fidgetin, an AAA protein that was identified as the protein encoded by the gene mutated in fidget mice. Because the phenotypes of fidget mice are reminiscent of the phenotypes of ciliopathy diseases, and because fidgetin …

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Cause of Death and Predictors of All‐Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF

Sean D. Pokorney, Jonathan Paul Piccini, Susanna R. Stevens, Manesh R. Patel et autres

BACKGROUND: Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. METHODS AND RESULTS: In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for …

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