Sheng-Hsien Chen

Systemic Treatment Strategies for Recurrent Hepatocellular Carcinoma Following Liver Transplantation: A 20-y Retrospective Analysis With Clinical Insights

Shih-Chao Hsu, Horng-Ren Yang, Sheng-Hsien Chen, Te-Hong Chen et autres

BACKGROUND: Recurrent hepatocellular carcinoma (HCC) following liver transplantation (LT) represents a major clinical challenge. Optimal treatment strategies for posttransplant recurrence or metastasis remain undefined. METHODS: We retrospectively analyzed 136 LT cases with recurrent or metastatic HCC where systemic therapy was applied in …

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Immune Checkpoint Inhibitors for Recurrent Hepatocellular Carcinoma After Liver Transplantation: Safety Under an Immunosuppression-Preserving Strategy

Shih-Chao Hsu, Sheng-Hsien Chen, Te-Hong Chen, Wei-Fan Hsu et autres

BACKGROUND Immune checkpoint inhibitors (ICIs) are widely used as first-line combination therapies for many cancers. However, ICIs are associated with an increased risk of graft rejection in patients requiring liver transplants, and the tumor response rate has yet to be determined. MATERIAL …

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Short-Term Outcomes of Conventional Laparoscopic versus Robot-Assisted Distal Pancreatectomy for Malignancy: Evidence from US National Inpatient Sample, 2005–2018

Jyun-Ming Huang, Sheng-Hsien Chen, Te-Hung Chen

BACKGROUND: The primary treatment for pancreatic cancer is surgical resection, and laparoscopic resection offers benefits over open surgery. This study aimed to compare the short-term outcomes of robot-assisted vs. conventional laparoscopic distal pancreatectomy. METHODS: Data of adults ≥ 20 years old with …

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Hypothalamic impairment underlying heat intolerance in pregnant mice

Cheng‐Hsien Lin, Sheng-Hsien Chen, Ching‐Ping Chang, Kao‐Chang Lin

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17β-Estradiol Accelerated Renal Tubule Regeneration in Male Rats After Ischemia/Reperfusion-Induced Acute Kidney Injury

Chia-Chun Wu, Chia‐Yu Chang, Sheng‐Tsung Chang, Sheng-Hsien Chen

Ischemic/reperfusion injury (IRI) is the most common cause of acute kidney injury (AKI). Murine studies report that pretreatment with 17β-estradiol protects against AKI using multiple mechanisms, but how 17β-estradiol is involved in regenerating tubular cells is unknown. To visualize the kidney injury …

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Attenuating spinal cord injury by conditioned medium from human umbilical cord blood-derived CD34+ cells in rats

Chia-Hong Yeng, Pei-Jarn Chen, Hsiu-Kang Chang, Wei-Yu Lo et autres

OBJECTIVE: Intravenous or intraspinal transplantation of human umbilical cord blood cells-derived CD34(+) cells (human CD34(+) cells) or mesenchymal stem cells after spinal cord injury (SCI) improved hind limb functional recovery in adult rats. The objective of this study is to ascertain whether …

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Therapeutic treatment with ascorbate rescues mice from heat stroke-induced death by attenuating systemic inflammatory response and hypothalamic neuronal damage

Chia‐Yu Chang, Jen‐Yin Chen, Sheng-Hsien Chen, Tain‐Junn Cheng et autres

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Implementation of an automated system for microscope pathological section image with RFID management

Pei-Jarn Chen, Chia-Hong Yeng, Ma-Mi Lu, Sheng-Hsien Chen

Purpose – The purpose of this paper is to establish an automated microscopic imaging database system using a set of Radio Frequency Identification (RFID) management functions to provide a secure storage for hispathology images. Design/methodology/approach – The automated microscopy imaging system is …

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Transplantation of Human Dental Pulp-Derived Stem Cells Protects against Heatstroke in Mice

Ling-Shu Tseng, Sheng-Hsien Chen, Mao‐Tsun Lin, Ying‐Chu Lin

Stem cells from human exfoliated deciduous tooth pulp (SHED) is a promising approach for the treatment of stroke and spinal cord injury. In this study, we investigated the therapeutic effects of SHED for the treatment of multiple organ (including brain, particularly hypothalamus) …

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Umbilical Cord Blood-Derived Stem Cells Improve Heat Tolerance and Hypothalamic Damage in Heat Stressed Mice

Ling-Shu Tseng, Sheng-Hsien Chen, Mao‐Tsun Lin, Ying‐Chu Lin

Heatstroke is characterized by excessive hyperthermia associated with systemic inflammatory responses, which leads to multiple organ failure, in which brain disorders predominate. This definition can be almost fulfilled by a mouse model of heatstroke used in the present study. Unanesthetized mice were …

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Decrease of PPAR δ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury

Cheng-Chia Tsai, Kung‐Shing Lee, Sheng-Hsien Chen, Li‐Jen Chen et autres

Changes in the peroxisome proliferator-activated receptors- δ (PPAR δ ) expression in rats after spinal cord injury (SCI) have been previously reported. Diabetic animals show a higher mortality after SCI. However, the relationship between the progress of diabetes and PPAR δ in …

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End-stage renal disease after hypertensive disorders in pregnancy

Chia-Chun Wu, Sheng-Hsien Chen, Chung‐Han Ho, Fu‐Wen Liang et autres

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