Javier A. Tello

Evidence on glucagon-like peptide-1 receptor agonists around conception: cautious interpretation (reply to letter to the editor)

Diya Rajesh, Jolie Hakim, Javier A. Tello

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Neonatal and obstetric outcomes following periconceptional exposure to glucagon-like peptide-1 receptor agonists: a systematic review and meta-analysis

Jolie Hakim, Diya Rajesh, Javier A. Tello

OBJECTIVE: To evaluate the association between periconceptional exposure to glucagon-like peptide-1 receptor agonists and fetal, pregnancy-related, obstetric, and delivery outcomes. DATA SOURCES: PubMed, Embase, and Web of Science were searched from database inception through November 2025 to identify relevant studies. STUDY ELIGIBILITY …

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MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor

Suli‐Anne Laurin, Gunnar Kleinau, Vidicha Chunilal, Andrew Morton et autres

Abstract The melanocortin-4 receptor is a G protein-coupled receptor and a key regulator of appetite and metabolism. It can interact with the melanocortin-receptor accessory protein 2, a single transmembrane helix protein known to interact with several different G protein-coupled receptors. However, the …

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Kisspeptin is elevated in the brain after intracerebral haemorrhagic stroke

Saumya Maheshwari, In Hwa Um, Struan Donachie, Karina McDade et autres

Intracerebral haemorrhage (ICH) is the most severe subtype of stroke, with a 2-year mortality of nearly 50% and the greatest rate of disability amongst stroke survivors. Whilst treatment options for ICH remain limited, the condition requires prompt identification and rapid intervention to …

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Tracking the origin of Tempranillo Tinto through whole genome resequencing and high-throughput genotyping

Javier A. Tello, Pablo Carbonell‐Bejerano, Rafael Torres‐Pérez, Yolanda Ferrada�s et autres

Grapevine cultivars are vegetatively propagated to maintain their varietal characteristics. This process of multiplication leads to spontaneous somatic mutations that can eventually generate a variant phenotype, of potential interest for cultivar improvement and innovation. However, regardless their phenotypic effect, somatic mutations stack …

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MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor

Iqra Sohail, Suli‐Anne Laurin, Gunnar Kleinau, Vidicha Chunilal et autres

ABSTRACT The melanocortin-4 receptor (MC4R) is a G protein-coupled receptor (GPCR) and a key regulator of appetite and metabolism. It can interact with the melanocortin-receptor accessory protein 2 (MRAP2), a single transmembrane helix protein known to interact with several different GPCRs. However, …

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Comparing ART outcomes in women with endometriosis after GnRH agonist versus GnRH antagonist ovarian hyperstimulation: A systematic review and meta-analysis

K. Kuan, Javier A. Tello

Background: Endometriosis can cause subfertility and women may require assisted reproductive technology (ART) to achieve their pregnancy goals. Objectives: To compare ART outcomes following the long GnRH-agonist and GnRH-antagonist controlled ovarian hyperstimulation (COH) protocols in patients with endometriosis. Search Strategy: MEDLINE, Embase, …

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Comparing ART outcomes in women with endometriosis after GnRH agonist versus GnRH antagonist ovarian stimulation: a systematic review

K. Kuan, Sean Omoseni, Javier A. Tello

Background: Endometriosis is an oestrogen-dependent disease that can cause subfertility in women who may require assisted reproductive technology (ART) to achieve their pregnancy goals. Objectives: The aim of this study was to compare ART outcomes in women with endometriosis following the long …

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Neurokinin 3 Receptor Antagonists Compared With Serotonin Norepinephrine Reuptake Inhibitors for Non-Hormonal Treatment of Menopausal Hot Flushes: A Systematic Qualitative Review

Sara J. Menown, Javier A. Tello

INTRODUCTION: Hot flushes/flashes (HFs) or other vasomotor symptoms affect between 45 and 97% of women during menopause. Hormone replacement therapy (HRT) is effective at alleviating menopausal symptoms, but some women cannot or prefer not to take HRT. Since current non-hormonal options have …

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Suppression of ovarian hormones in adolescent rats has no effect on anxiety‐like behaviour or c‐fos activation in the amygdala

Amy R. Hodgson, Claire Richmond, Javier A. Tello, Gillian R. Brown

In humans, sex differences in mood disorders emerge during adolescence, with prevalence rates being consistently higher in females than males. It has been hypothesised that exposure to endogenous ovarian hormones during adolescence enhances the susceptibility of females to mood disorders from this …

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Ovarian hormones induce de novo DNA methyltransferase expression in the Siberian hamster suprachiasmatic nucleus

Christopher Coyle, Federico Caso, Elisabetta Tolla, Perry Barrett et autres

The present study investigated neuroanatomically localised changes in de novo DNA methyltransferase expression in the female Siberian hamster (Phodopus sungorus). The objectives were to identify the neuroendocrine substrates that exhibit rhythmic Dnmt3a and Dnmt3b expression across the oestrous cycle and also examine …

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The dyslexia susceptibility KIAA0319 gene shows a specific expression pattern during zebrafish development supporting a role beyond neuronal migration

Monika Gostić, Angela Martinelli, Carl S. Tucker, Zhengyi Yang et autres

Dyslexia is a common neurodevelopmental disorder caused by a significant genetic component. The KIAA0319 gene is one of the most robust dyslexia susceptibility factors but its function remains poorly understood. Initial RNA-interference studies in rats suggested a role in neuronal migration whereas …

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