Perry Barrett

Daily torpor in the Djungarian hamster (Phodopus sungorus) is orchestrated by the suprachiasmatic nucleus: evidence from immediate early gene mapping and nucleus-specific sequencing

Elena Haugg, Victoria Diedrich, Ceyda Cubuk-Charalampous, Janus Borner et autres

Spontaneous daily torpor in the Djungarian hamster is a precisely timed energy-saving strategy that occurs in winter to withstand challenging conditions. It features a transient but pronounced decrease in metabolic rate, body temperature and other physiological parameters. The hypothalamus is thought to …

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A missense mutation in zinc finger homeobox‐3 ( ZFHX3 ) impedes growth and alters metabolism and hypothalamic gene expression in mice

Patrick M. Nolan, Gareth T. Banks, Nora Bourbia, Ashleigh G. Wilcox et autres

Abstract A protein altering variant in the gene encoding zinc finger homeobox‐3 ( ZFHX3 ) has recently been associated with lower BMI in a human genome‐wide association study. We investigated metabolic parameters in mice harboring a missense mutation in Zfhx3 ( Zfhx3 …

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A missense mutation in zinc finger homeobox-3 (ZFHX3) impedes growth and alters metabolism and hypothalamic gene expression in mice

Patrick M. Nolan, Gareth T. Banks, Nora Bourbia, Ashleigh G. Wilcox et autres

Abstract A protein altering variant in the gene encoding zinc finger homeobox-3 ( ZFHX3 ) has recently been associated with lower BMI in a human genome-wide association study. We investigated metabolic parameters in mice harbouring a missense mutation in Zfhx3 ( Zfhx3 …

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CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake

Andrew R. McEwan, Connor Davidson, Elizabeth A. Hay, Yvonne D. Turnbull et autres

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Tanycytes and Their Pivotal Role in Seasonal Physiological Adaptations

Perry Barrett, Peter J. Morgan

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Ovarian hormones induce de novo DNA methyltransferase expression in the Siberian hamster suprachiasmatic nucleus

Christopher S. Coyle, Federico Caso, Elisabetta Tolla, Perry Barrett et autres

The present study investigated neuroanatomically localised changes in de novo DNA methyltransferase expression in the female Siberian hamster (Phodopus sungorus). The objectives were to identify the neuroendocrine substrates that exhibit rhythmic Dnmt3a and Dnmt3b expression across the oestrous cycle and also examine …

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Disruption of an enhancer associated with addictive behaviour within the cannabinoid receptor-1 gene suggests a possible role in alcohol intake, cannabinoid response and anxiety-related behaviour

Elizabeth A. Hay, Andrew R. McEwan, Dana Wilson, Perry Barrett et autres

The cannabinoid-1 receptor (CB1) plays a critical role in a number of biological processes including nutrient intake, addiction and anxiety-related behaviour. Numerous studies have shown that expression of the gene encoding CB1 (CNR1) is highly dynamic with changes in the tissue specific …

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Genome sequencing and transcriptome analyses of the Siberian hamster hypothalamus identify mechanisms for seasonal energy balance

Riyue Bao, Kenneth G. Onishi, Elisabetta Tolla, Fran Ebling et autres

Synthesis of triiodothyronine (T 3 ) in the hypothalamus induces marked seasonal neuromorphology changes across taxa. How species-specific responses to T 3 signaling in the CNS drive annual changes in body weight and energy balance remains uncharacterized. These experiments sequenced and annotated …

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Fat, carbohydrate and protein by oral gavage in the rat can be equally effective for satiation

Nikki Cassie, Richard Lee Anderson, Dana Wilson, Julian G. Mercer et autres

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Editorial: Thirty years of Journal of Neuroendocrinology

Julian G. Mercer, Perry Barrett

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Genetic, epigenetic and pharmacological influences modulating tissue specific regulation of the cannabinoid receptor-1 gene (CB 1 ); implications for cannabinoid pharmacogenetics

Elizabeth A. Hay, Philip Cowie, Andrew R. McEwan, Dana Wilson et autres

Abstract Cannabinoid receptor-1 (CB 1 ) represents a potential drug target against conditions that include obesity and substance abuse. However, drug trials targeting CB 1 (encoded by the CNR1 gene) have been compromised by differences in patient response. Towards addressing the hypothesis …

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Safety, tolerability and impact on viral reservoirs of the addition to antiretroviral therapy of ABX464, an investigational antiviral drug, in individuals living with HIV-1: a Phase IIa randomised controlled study

Sofie Rutsaert, Jean-Marc Steens, Paul Gineste, Basiel Cole et autres

To assess the safety and tolerability as well as antiretroviral impact of ABX464, an oral investigational drug with a novel mechanism of HIV-1 inhibition (ClinicalTrials.gov NCT02735863). Randomised, double-blind, placebo-controlled, Phase IIa study in individuals living with HIV-1 on antiretroviral therapy at six …

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