Jie Zhang

Single-cell analysis of fetal testis reveals dysfunction of human Leydig cells in Klinefelter syndrome

Tong Yan, Guancheng Chen, Jie Zhang, Wenjing Jia et autres

Klinefelter syndrome (KS), the most common sex chromosome aneuploidy (affecting approximately 1 in 650 live male births), causes severe infertility. The extra X chromosome can impair the development of fetal germ cells, but its effects on somatic cells, especially Leydig cells, are …

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Optimal selection of ovarian stimulation protocol for infertile women with diminished ovarian reserve based on Bologna and POSEIDON criteria: a network meta-analysis

Ting Zhu, Jie Zhang, Xi Zhang, Yi Zhou et autres

BACKGROUND: Patients with diminished ovarian reserve (DOR) present a significant challenge in assisted reproductive technology due to their poor ovarian response and lower pregnancy rates. Although multiple ovarian stimulation protocols are available, the optimal regimen for DOR patients remains uncertain, largely due …

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Association Between Metabolic Score for Insulin Resistance (METS-IR) and Risk of Infertility: Evidence from NHANES 2013–2020 and Mendelian Randomization Study

Li X, Sun Q, Jie Zhang, Ling X et autres

Xin Li,1 Qixi Sun,1 Juanjuan Zhang,1 Xiufeng Ling,1 Yu Liu,2 Chun Zhao1 1Department of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing, People’s Republic of China; 2Department of Obstetrics and Gynecology, Women’s Hospital of Nanjing …

Noninvasive prenatal diagnosis of 21-hydroxylase deficiency using target capture sequencing of maternal plasma DNA

Daqing Ma, Yuan Yu, Cheng Luo, Y Wang et autres

Prenatal dexamethasone treatment has been suggested over three decades ago to prevent virilization of a female fetus affected with 21-hydroxylase deficiency due to genetic mutations in the CYP21A2 gene. However, current treatment guidelines for CAH regard this treatment still as experimental, mainly …

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[Characterization of ovarian adrenal rest tumors in children and adolescent females with congenital adrenal hyperplasia due to 21-hydroxylase deficiency].

Zhiguang Su, Li Yy, Ma Hm, Jie Zhang et autres

OBJECTIVE: To summarize the characterization of ovarian adrenal rest tumors (OART) in children and adolescent females with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD). METHOD: We have diagnosed 4 cases of CAH 21-OHD with OART in the recent 5 years …

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