Luisina Ines Bruno

Closing the gap in germline testing in patients with cancer through a clinic-based awareness initiative: From booth to patient's agenda.

Luisina Ines Bruno, Guillermo Alberto, Agostina Tardivo, Andres Rodriguez et autres

1603 Background: Germline genetic testing (GT) is a standard of care for a broad range of patients (pts) diagnosed with cancer due to expanded guidelines and targeted treatments options. The consequent identification of hereditary cancer susceptibility syndromes (HCS) enables optimal surveillance measures, …

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Germline BRCA - Lynch Syndrome MINAS: Report of Six Argentinian families and a systematic review of the literature

Guillermo Alberto, Fernando Tortosa, Maria Dolores Mansilla Figueroa, Marina Antelo et autres

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Targeted therapies in neoadjuvant treatment for gastroesophageal cancer

Berenice Freile, Andrés Rodríguez, Greta Catani, Marcos Daniel Bortz et autres

Gastroesophageal cancers are among the most prevalent cancers globally and represent the third leading cause of cancer-related mortality worldwide. Surgical resection remains the primary curative approach for localised and locally advanced stages, but its effectiveness is limited for locally advanced diseases, evidenced …

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The impact of ovarian function suppression with adjuvant endocrine therapy on survival outcomes in young germline BRCA mutation carriers with breast cancer: Secondary analysis of an international cohort study.

Paola Zagami, Yara George Abdou, Virginia Delucchi, Hee Jeong Kim et autres

507 Background: In young women with hormone receptor-positive (HR+) breast cancer (BC), ovarian function suppression (OFS) has been shown to improve outcomes when combined with adjuvant endocrine therapy (ET). However, limited evidence exists on its efficacy in germline BRCA (gBRCA) carriers. Here …

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Patients with Colorectal Cancer and BRAFV600E-Mutation in Argentina: A Real-World Study—The EMOGI-CRC01 Study

Greta Catani, Stefano Chong Hun Kim, Federico Waisberg, Diego Hernán Enrico et autres

Background/Objectives: The BRAF-mutation is a poor prognostic factor in colorectal cancer (CRC). There is a need for real-world data in low-middle-income countries regarding clinical characteristics, outcomes, and treatment strategies. This study aims to describe progression-free survival (PFS) and in the first- and …

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Characterization of Screening Strategies for Lynch Syndrome in Latin America

Anthony Vladimir Campos-Segura, Karin Álvarez, Bernard Rossi, Mábel Bohórquez et autres

BACKGROUND & AIMS: In Latin America, genetic testing for Lynch syndrome (LS) has been partially implemented. Traditionally, LS diagnosis relied on the Amsterdam criteria and Bethesda guidelines, collectively known as traditional screening (TS). However, TS may miss up to 68% of LS …

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Patients with Colorectal Cancer and BRAFV600E-Mutation in Argentina: A Real-World Study: The EMOGI-CRC01 Study

Greta Catani, Stefano Chong Hun Kim, Federico Waisberg, Diego Hernán Enrico et autres

Background/Objectives: BRAF-mutation is a poor prognostic factor in colorectal cancer (CRC). There is a need for real-world data in low-middle-income countries regarding clinical characteristics, outcomes, and treatment strategies. This study aims to describe progression free survival (PFS) and overall survival (OS) in …

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[Hyperprogression in a patient with colorectal cancer and repair protein deficiency: a diagnostic and therapeutic challenge].

Greta Catani, Federico Esteso, Luisina Ines Bruno, Andrés Rodríguez et autres

Metastatic colorectal cancer (mCRC) represents a significant global public health challenge. The identification of biomarkers such as microsatellite instability (MSI) and the status of mismatch repair (MMR) proteins, among others, provides crucial information for guiding therapeutic decisions and predicting prognosis. Immune checkpoint …

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Cáncer Colorrectal En adultos jóvenes: Experiencia mono institucional

Greta Catani, Federico Waisberg, Luisina Ines Bruno, Marcos Daniel Bortz et autres

Introducción: El cáncer colorrectal (CCR) en adultos jóvenes es una entidad cada vez más prevalente y se estima que en la próxima década 1 de cada 4 pacientes sea menor de 50 años. En nuestro país existen pocos datos de este subgrupo …

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Targeted Therapies in Neoadjuvant Treatment for Gastroesophageal Cancer

Berenice Freile, Andrés Rodríguez, Greta Catani, Marcos Daniel Bortz et autres

Gastroesophageal cancers, are among the most prevalent cancers globally and represent the third leading cause of cancer-related mortality worldwide. Surgical resection remains the primary curative approach for localized and locally advanced stages, but its effectiveness is limited for locally advanced diseases, evidenced …

Impact of peridiagnostic genetic counseling and germline testing on treatment decisions for patients with triple negative breast cancer undergoing pembrolizumab-chemotherapy neoadjuvant approach.

Luisina Ines Bruno, Guillermo Alberto, Laura Sabina Lapuchesky, Andrés Rodríguez et autres

e12633 Background: Triple negative breast cancer (TNBC) has been globally associated with a high risk of carrying pathogenic or likely pathogenic (P/LP) variants in germline breast cancer (BC) susceptibility genes (BCSG). Immunotherapy- based Neoadjuvant (pembro-NA) treatment is the preferred approach for localized, …

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Protocolo sobre el rol del asesoramiento genético oncológico en el marco de oncología de precisión

Luisina Ines Bruno, Andrés Rodríguez Romero, Melina Winocur, Alejandro Risso Vázquez et autres

El Asesoramiento Genético Oncológico (AGO) es el proceso a través del cual se estratifica el riesgo genético de desarrollar cáncer de un individuo o grupo familiar y es un estándar de cuidado con comprobado beneficio. Recientemente, se sumó el desarrollo de drogas …

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