Ping‐Zhao Liang

Spatiotemporally Asynchronous Dual-Modality Probe: Real-Time and Accurate Monitoring of Neutrophil Recruitment in Phototherapy Prognosis

Ping‐Zhao Liang, Y. H. Yan, Long He, Li−Li Ren et autres

The persistent issue of poor prognosis in tumor recurrence and metastasis, even with promising treatments such as photodynamic therapy, underscores the urgent need for noninvasive imaging tools to investigate underlying mechanisms. However, achieving real-time, crosstalk-free monitoring of multiple biomarkers within pathological processes …

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Hydrogen‐Bond Network‐Directed Controllable Assembly of Stable Cyanine J‐Aggregates for Long‐Term and High‐Contrast In Vivo Imaging

Feiyu Yang, Yifeng Ou, Jun‐Liang Zhou, Ping‐Zhao Liang et autres

Optical probes based on near-infrared region (NIR) small-molecule dyes have emerged as an indispensable tool for contemporary in vivo biomedical research. Nevertheless, the majority of the reported NIR small-molecule probes are plagued by issues such as poor stability, short excitation wavelength, and …

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Hydrogen‐Bond Network‐Directed Controllable Assembly of Stable Cyanine J‐Aggregates for Long‐Term and High‐Contrast In Vivo Imaging

Feiyu Yang, Yifeng Ou, Jun‐Liang Zhou, Ping‐Zhao Liang et autres

ABSTRACT Optical probes based on near‐infrared region (NIR) small‐molecule dyes have emerged as an indispensable tool for contemporary in vivo biomedical research. Nevertheless, the majority of the reported NIR small‐molecule probes are plagued by issues such as poor stability, short excitation wavelength, …

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Visualization of Immune Rejection: Noninvasive Imaging/Efficacy Evaluation of Immune Rejection after Liver Transplantation via Stable NIR-II Scaffolds

Li Xu, Haoming Chen, Zuojia Qin, Ping‐Zhao Liang

Liver transplantation is the only definitive treatment to cure liver failure in the clinic. However, patients undergoing allogeneic liver transplantation often experience immune rejection, which can lead to significant liver damage or even recurrent liver failure. Currently, the clinically used method for …

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Development of NIR‐II Ratiometric Fluorescent Nanoprobe for HClO Imaging in Acute Lung Injury

Feiyu Yang, Jie Wang, Xiaopeng Fan, Zhe Li et autres

Efficient and high-contrast bioimaging of acute lung injury (ALI) is crucial for studying disease progression and enabling timely interventional treatments. However, developing bioimaging probes in the second near-infrared (NIR-II) window to assess ALI remains challenging. In particular, ratiometric NIR-II probes with self-calibration …

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An Activatable Fluorescence/Photoacoustic Bimodal Probe for the Detection of Drug-Induced Liver Senescence

Y. H. Yan, Junliang Zhou, Lili Ren, Ping‐Zhao Liang et autres

Senescence is an intricate physiological progression that can be instigated by a multiplicity of factors. Aberrant cellular senescence is capable of precipitating a substantial array of diseases. During chemotherapy, drugs typically tend to gradually accumulate in the liver, thereby inducing liver senescence …

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Activatable Photosensitizer Prodrug for Self‐Amplified Immune Therapy Via Pyroptosis

Ping‐Zhao Liang, Lili Ren, Y. H. Yan, Zhe Li et autres

Abstract Immunotherapy is a promising cancer treatment, but its application is hindered by tumors’ low immunogenicity and the difficulty of immune cell infiltration. Here, to address above issues and achieve targeted tumor treatment, we designed the first activated small molecule photosensitizer immune‐prodrug …

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Activatable Photosensitizer Prodrug for Self‐Amplified Immune Therapy Via Pyroptosis

Ping‐Zhao Liang, Lili Ren, Y. H. Yan, Zhe Li et autres

Immunotherapy is a promising cancer treatment, but its application is hindered by tumors' low immunogenicity and the difficulty of immune cell infiltration. Here, to address above issues and achieve targeted tumor treatment, we designed the first activated small molecule photosensitizer immune-prodrug HDIM …

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Development of Dual-Responsive Fluorescent Probe for Drug Screening of Diabetes Cardiomyopathy

Ping‐Zhao Liang, Zhe Li, Xingxing Zhang, Feiyu Yang et autres

For specific drug research and development, a drug-screening strategy (DSS) plays an indispensable role in the biomedical field. Unfortunately, traditional strategies are complicated and insufficiently accurate due to the widely used single-target screening method. Herein, a simple dual-target-based drug-screening strategy (dt-DSS) is …

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Superoxide Anion-Mediated Afterglow Mechanism-Based Water-Soluble Zwitterion Dye Achieving Renal-Failure Mice Detection

Zhe Li, Li Xu, Jinyu Li, Lingling Lei et autres

Afterglow materials-based biological imaging has promising application prospects, due to negligible background. However, currently available afterglow materials mainly include inorganic materials as well as some organic nanoparticles, which are difficult to translate to the clinic, resulting from non-negligible metabolic toxicity and even …

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Three positive charge nonapoptotic-induced photosensitizer with excellent water solubility for tumor therapy

Zhe Li, Ping‐Zhao Liang, Li Jun Xu, Feiyu Yang et autres

Orderly Self‐Assembly of Organic Fluorophores for Sensing and Imaging

Zhe Li, Ping‐Zhao Liang, Tian‐Bing Ren, Lin Yuan et autres

Abstract Fluorescence imaging utilizing traditional organic fluorophores is extensively applied in both cellular and in vivo studies. However, it faces significant obstacles, such as low signal‐to‐background ratio (SBR) and spurious positive/negative signals, primarily due to the facile diffusion of these fluorophores. To …

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