Thomas Bradbury

Patients with COPD prioritise chronic symptoms and functional impact as key outcomes in exacerbation trials

Sachin Ananth, Fekri Abroug, Àlvar Agustí, Per Bakke et autres

Introduction: Patient perspectives are essential to establish relevant outcomes in trials assessing COPD treatments. Aim: To assess which trial outcomes for exacerbation treatments are most important for patients with COPD. Methods: Patients with COPD underwent semi-structured interviews where they stated what outcomes …

us, Tunisie, es, no, gr, it, gb, au, be, ch, md, hu, ru, by, dk, cn (code pays fourni par la source)

Acute effects of low-dose bisoprolol on lung function and blood pressure in COPD patients

Thomas Bradbury, Allison Martin, Robert J. Hancox, Catherina L. Chang et autres

Background and objective Recent observational data suggest that cardioselective β-blockers like bisoprolol are safe and beneficial for patients with COPD. However, the acute effects of bisoprolol on lung and cardiovascular function in these patients is unclear, a gap that this study aimed …

au, nz, nl, in, lk (code pays fourni par la source)

Exacerbation outcome definitions in clinical trials of COPD interventions: a systematic review

Thomas Bradbury, Sachin Ananth, Syedah Sarah Hussaini, A Mathioudakis et autres

Introduction: In clinical trials of COPD interventions, the underlying definition of an “exacerbation” as a measured outcome remains inconsistent and unstandardised. This study reviews published clinical trials to describe how these medical events are defined as trial outcomes. Method: Journal articles describing …

au, gb (code pays fourni par la source)

Blood Eosinophils in Chinese COPD Participants and Response to Treatment with Combination Low-Dose Theophylline and Prednisone: A Post-Hoc Analysis of the TASCS Trial

Thomas Bradbury, Gian Luca Di Tanna, Anish Scaria, Allison Martin et autres

Thomas Bradbury,1 Gian Luca Di Tanna,1 Anish Scaria,1 Allison Martin,1 Fu-Qiang Wen,2 Nan-Shan Zhong,3 Jin-Ping Zheng,3 Peter J Barnes,4 Bartolome Celli,5 Norbert Berend,1 Christine R Jenkins1 On behalf of the TASCS Investigators1Respiratory Group, The George Institute for Global Health, Sydney, NSW 2042, …

au, cn, gb, us (code pays fourni par la source)

Assessing Treatment Success or Failure as an Outcome in Randomised Clinical Trials of COPD Exacerbations. A Meta-Epidemiological Study

Alexander G. Mathioudakis, Sachin Ananth, Thomas Bradbury, Balázs Csoma et autres

A recently published ERS core outcome set recommends that all trials of COPD exacerbation management should assess the treatment success (or "cure" of the exacerbation), defined as a dichotomous measure of the overall outcome of an exacerbation. This methodological systematic review describes …

gb, au, hu, dk, us, it (code pays fourni par la source)

S101 Methods for assessing the success or failure of COPD exacerbation treatments in therapeutic clinical trials: A meta-epidemiological systematic review

AG Mathioudakis, Sachin Ananth, Thomas Bradbury, Balázs Csoma et autres

Introduction The overall outcome of a COPD exacerbation (treatment success or failure) is a critical outcome for clinical trials evaluating the management of COPD exacerbations. However, trials use heterogeneous definitions and instruments to evaluate this outcome, limiting the comparability of trial results. …

gb, au, hu, dk (code pays fourni par la source)

ERS statement: a core outcome set for clinical trials evaluating the management of COPD exacerbations

Alexander G. Mathioudakis, Fekri Abroug, Àlvar Agustí, Sachin Ananth et autres

Clinical trials evaluating the management of acute exacerbations of COPD assess heterogeneous outcomes, often omitting those that are clinically relevant or more important to patients. We have developed a core outcome set, a consensus-based minimum set of important outcomes that we recommend …

gb, Tunisie, es, no, gr, it, au, be, nl, ch, md, us, hu, ru, by, dk, cn (code pays fourni par la source)

Effect of Hemodiafiltration on the Progression of Neuropathy with Kidney Failure

Amy Kang, Ria Arnold, Martin Gallagher, Paul Snelling et autres

Background and objectives Neuropathy is a common complication of kidney disease that lacks proven disease-modifying treatments. Hemodiafiltration improves clearance of uremic toxins and is associated with better nerve function than hemodialysis. We aimed to determine whether hemodiafiltration reduces the progression of neuropathy …

au, us (code pays fourni par la source)

The effect of low-dose corticosteroids and theophylline on the risk of acute exacerbations of COPD: the TASCS randomised controlled trial

Christine Jenkins, Fuqiang Wen, Allison Martin, Peter J. Barnes et autres

Background The highest burden of chronic obstructive pulmonary disease (COPD) occurs in low- and middle-income countries. Low-cost oral medications, if effective, could enable affordable, accessible COPD treatment. Methods In this randomised, three-arm, double-blind, double-dummy, placebo-controlled study conducted in 37 centres in China, …

au, cn, gb, us (code pays fourni par la source)

Core outcome set for the management of acute exacerbations of chronic obstructive pulmonary disease: the COS-AECOPD ERS Task Force study protocol

Alexander G. Mathioudakis, Fekri Abroug, Àlvar Agustí, Per Bakke et autres

Randomised controlled trials (RCTs) on the management of COPD exacerbations evaluate heterogeneous outcomes, often omitting those that are clinically important and patient relevant. This limits their usability and comparability. A core outcome set (COS) is a consensus-based minimum set of clinically important …

gb, Tunisie, es, no, gr, it, au, be, nl, ch, md, us, hu, ru, by, dk, cn (code pays fourni par la source)

Reliability, Validity, and Responsiveness of the Western Ontario and McMaster Universities Osteoarthritis Index for Elderly Patients with a Femoral Neck Fracture

P.T.P.W. Burgers, Rudolf W. Poolman, Theodorus M. J. van Bakel, Wim E. Tuinebreijer et autres

BACKGROUND: The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) has been extensively evaluated in groups of patients with osteoarthritis, yet not in patients with a femoral neck fracture. This study aimed to determine the reliability, construct validity, and responsiveness of the …

nl, ca (code pays fourni par la source)

Assessing the effects of behavioral marital therapy: Assumptions and measurement strategies

Thomas Bradbury

us (code pays fourni par la source)