Margaret G. Petroff

Immunology of Pregnancy

Margaret G. Petroff, Sean L. Nguyen

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Impact of antibiotics on membrane vesicle production in Group B Streptococcus

Macy E. Pell, Cole R. McCutcheon, Jennifer A. Gaddy, David M. Aronoff et autres

ABSTRACT Group B Streptococcus (GBS) is an important bacterial pathogen during pregnancy, colonizing up to 35% of pregnant people recto-vaginally. Intrauterine GBS infection during pregnancy can cause preterm labor, early membrane rupture, and, if the fetus gets infected, stillbirth or early-onset disease …

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Autoimmune regulator deficiency causes sterile epididymitis and impacts male fertility through disruption of inorganic physiology

Soo Hyun Ahn, Katrina Halgren, Geoffrey Grzesiak, Keith W. MacRenaris et autres

Autoimmune regulator (AIRE), a transcriptional regulator expressed by medullary thymic epithelial cells, is required for shaping the self-antigen tolerant T cell receptor repertoire. In humans, AIRE mutations caues autoimmune polyglandular syndrome type 1. Among other symptoms, men with autoimmune polyglandular syndrome type …

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Autoimmune regulator deficiency causes sterile epididymitis and impacts male fertility through disruption of inorganic physiology

Soo Hyun Ahn, Katrina Halgren, Geoffrey Grzesiak, Keith W. MacRenaris et autres

Abstract Autoimmune regulator (AIRE), a transcription factor expressed by medullary thymic epithelial cells, is required for shaping the self-antigen tolerant T cell receptor repertoire. Humans with mutations in AIRE suffer from Autoimmune Polyglandular Syndrome Type 1 (APS-1). Among many symptoms, men with …

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Group B Streptococcal Membrane Vesicles Induce Proinflammatory Cytokine Production and Are Sensed in an NLRP3 Inflammasome-Dependent Mechanism in a Human Macrophage-like Cell Line

Cole R. McCutcheon, Jennifer A. Gaddy, David M. Aronoff, Shannon D. Manning et autres

High Resolution Image Download MS PowerPoint Slide Group B Streptococcus (GBS) is a major cause of fetal and neonatal mortality worldwide. Many of the adverse effects of invasive GBS are associated with inflammation; therefore, understanding bacterial factors that promote inflammation is of …

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Changes in thyroid hormone concentrations over time in dogs with autoimmune thyroiditis

Rebecca Egbert, Puja Basu, Kent R. Refsal, Margaret G. Petroff et autres

OBJECTIVE: The objective of this study was to follow long-term changes in the concentration of thyroid hormones in dogs with subclinical thyroiditis. SAMPLES: Samples were obtained from 125 dogs with subclinical thyroiditis. The study population included 70 female and 55 male dogs. …

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Autoimmune regulator deficiency causes sterile epididymitis and infertility characterized by infiltration of iron-laden macrophages

Soo Hyun Ahn, Geoffrey Grzesiak, Katrina Halgren, Keith W. MacRenaris et autres

Abstract Men with Autoimmune Polyglandular Syndrome Type 1 (APS-1), a disease caused by a mutation in the gene encoding Autoimmune regulator (Aire), can suffer infertility, but the mechanism is not known. Using transgenic animals and a novel mass spectrometry to detect trace …

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HPV+ head and neck cancer–derived small extracellular vesicles communicate with TRPV1+ neurons to mediate cancer pain

Kufreobong E. Inyang, Christine M. Evans, Matthew Heussner, Margaret G. Petroff et autres

ABSTRACT: Severe pain is often experienced by patients with head and neck cancer and is associated with a poor prognosis. Despite its frequency and severity, current treatments fail to adequately control cancer-associated pain because of our lack of mechanistic understanding. Although recent …

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Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia

Guoli Zhou, E. Winn, Duong Nguyen, Eric P. Kasten et autres

Pre-eclampsia (PE) is a hypertensive condition that occurs during pregnancy and complicates up to 4% of pregnancies. PE exhibits several circadian-related characteristics, and the placenta possesses a functioning molecular clock. We examined the associations of 17 core circadian gene transcripts in placenta …

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Impact of Estrogen and Progesterone on Immune Cells and Host–Pathogen Interactions in the Lower Female Reproductive Tract

Morgan K. Collins, Cole R. McCutcheon, Margaret G. Petroff

Microbial infections are a threat to women's reproductive health. Although reproductive cycles and pregnancy are controlled by sex hormones, the impact of hormones on host-pathogen interactions and immune function in the female reproductive tract are understudied. Furthermore, the changing endocrine environment throughout …

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Head and Neck Cancer-derived small extracellular vesicles sensitize TRPV1+ neurons to mediate cancer pain

Kufreobong E. Inyang, Christine M. Evans, Matthew Heussner, Margaret G. Petroff et autres

Summary Severe pain is often experienced by patients with head and neck cancer and is associated with a poor prognosis. Despite its frequency and severity, current treatments fail to adequately control cancer-associated pain, because of our lack of mechanistic understanding. Cancer-derived small …

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Isolation and characterization of uterine leukocytes collected using a uterine swab technique

Parveen Parasar, Matthew P. Bernard, Soo Hyun Ahn, Sarika Kshirsagar et autres

Abstract Problem Leukocytes from the maternal‐fetal interface are a valuable tool to study local changes in immune function during pregnancy; however, sampling can be challenging due to inadequate tissue availability and the invasive nature of placental bed biopsy. Here, we aim to …

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