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Jinhan Sheng, Tianyu Ma, Yu Wu, Ming Wang
biodistribution. As such, programmable delivery of PROTACs that offer spatial and temporal control over where and when TPD occurs is urgently needed. In this review, we summarize the most recent advances in PROTAC delivery using nanoparticles, with a focus on the chemistry …
cn (code pays fourni par la source)
Wenting Li, Wenlu Li, Xiaolin Zhu, Yizhou Yan et autres
Abstract The elimination of antibiotic‐resistant bacteria (ARB) and their antibiotic resistance genes (ARGs) requires photocatalysts with strong oxidative surfaces and efficient charge separation under natural light. Herein, a novel donor‐acceptor (D‐A) supramolecular photocatalyst, SA‐PDI@C 60 , is reported for natural light‐driven antibacterial …
cn (code pays fourni par la source)
Xianghan Chen, Qizhen Zheng, Weiqi Cai, Jinhan Sheng et autres
Hydrogen-bonded organic frameworks (HOFs) are a novel class of porous nanomaterials that show great potential for intracellular delivery of protein therapeutics. However, the inherent challenges in interfacing protein with HOFs, and the need for spatiotemporally controlling the release of protein within cells, …
cn (code pays fourni par la source)
Qizhen Zheng, Jinhan Sheng, Ji Liu, Xianghan Chen et autres
Biomineralization of metal–organic frameworks (MOFs) provides a powerful approach for intracellular protein delivery, enabling the study of biological function and therapeutic potential of proteins. However, the potency of this approach is largely challenged by the low efficiency of current strategies for interfacing …
cn (code pays fourni par la source)
Wenting Li, Leihou Shao, Ji Liu, Jinhan Sheng et autres
and in tumor-bearing mouse xenografts. This strategy of delivering bacterial effectors using biodegradable lipid nanoparticles can be expanded for cancer cell signaling regulation and antitumor studies.
cn (code pays fourni par la source)
Ji Liu, Jinhan Sheng, Leihou Shao, Qizhen Zheng et autres
The delivery of protein into mammalian cells enables the dissection and manipulation of biological processes; however, this potency is challenged by the lack of an efficient protein delivery tool and a means to monitor its intracellular trafficking. Herein, we report that the …
cn (code pays fourni par la source)
Ji Liu, Jinhan Sheng, Leihou Shao, Qizhen Zheng et autres
Abstract The delivery of protein into mammalian cells enables the dissection and manipulation of biological processes; however, this potency is challenged by the lack of an efficient protein delivery tool and a means to monitor its intracellular trafficking. Herein, we report that …
cn (code pays fourni par la source)
Jiakang Tang, Ji Liu, Qizhen Zheng, Wenting Li et autres
Hydrogen-bonded organic frameworks (HOFs) are porous materials with great potential for biological applications. The self-assembly of HOFs and biomacromolecules, however, is challenging. We report herein the self-assembly of nanoscale HOFs (nHOFs) to encapsulate protein for intracellular biocatalysis. The self-assembly of tetrakis(4-amidiniumphenyl)methane and …
cn (code pays fourni par la source)
Jiakang Tang, Ji Liu, Qizhen Zheng, Wenting Li et autres
Abstract Hydrogen‐bonded organic frameworks (HOFs) are porous materials with great potential for biological applications. The self‐assembly of HOFs and biomacromolecules, however, is challenging. We report herein the self‐assembly of nanoscale HOFs (nHOFs) to encapsulate protein for intracellular biocatalysis. The self‐assembly of tetrakis(4‐amidiniumphenyl)methane …
cn (code pays fourni par la source)
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