Elizabeth Donato

Spatial multi-omics and single-cell transcriptomics uncover senescence-associated cellular programs during colon adenoma to cancer progression

Ming Yu, Yumo Xie, Lena Allen, Kelly Carter et autres

Abstract Colorectal cancer develops through a normal-adenoma-carcinoma sequence, yet only 5-10% of adenomas progress to malignancy, and the cellular programs governing that sequence remain poorly defined. Here we generate a spatial multi-omics atlas of human colon adenomas, combining Visium CytAssist and protein …

Afrique du Sud, us (code pays fourni par la source)

Abstract 6749: Spatial transcriptomics profiling of colorectal cancer tumors in Alaska Native peoples: Discovery of prognostic biomarkers

Garrick Chang, Diana Redwood, Amanda Koehne, Matthew Fitzgibbon et autres

Abstract Colorectal cancer (CRC) is the third most commonly diagnosed cancer and has the second-highest mortality rate overall in the United States (US). Appreciable population differences in incidence and mortality rates persist in the US. These differences are particularly pronounced among Alaska …

Afrique du Sud, us (code pays fourni par la source)

Abstract A087: Spatial-resolved single-cell analysis of the tumor microenvironment in Alaska Native colorectal cancer patients reveals novel biomarkers for prognosis

Hang Yin, Diana Redwood, Kimberly S. Smythe, Kristin Robinson et autres

Abstract Alaska Native peoples experience high colorectal cancer (CRC) incidence and mortality rates, which Alaska tribal health organizations are working to address. To reduce the high rates, it is important to understand the biological mechanisms that drive risk and survival outcomes. The …

us (code pays fourni par la source)

Supplemental Table 2 from The Translational Research Program in Cancer Differences across Populations

Jane C. Figueiredo, Diana Redwood, Li Li, Elizabeth Donato et autres

Supplemental Table 2 Shows a summary of Translational Research Program in Colorectal Cancer Disparities physical repository of colorectal cancer patients stratified by case-control status

Supplemental Figure 1 from The Translational Research Program in Cancer Differences across Populations

Jane C. Figueiredo, Diana Redwood, Li Li, Elizabeth Donato et autres

Supplemental Figure 1. Shows the process for requesting data from Alaska Native peoples from the Alaska Native Tribal Health Consortium and accessible via the NIH dbGaP data repository.

Supplemental Table 1 from The Translational Research Program in Cancer Differences across Populations

Jane C. Figueiredo, Diana Redwood, Li Li, Elizabeth Donato et autres

Supplemental Table 1 shows a Summary of Translational Research Program in Colorectal Cancer Disparities virtual repository of colorectal cancer patients.

Data from The Translational Research Program in Cancer Differences across Populations

Jane C. Figueiredo, Diana Redwood, Li Li, Elizabeth Donato et autres

AbstractBackground: Cancer incidence and mortality vary substantially across populations. The Translational Research Program in Cancer Differences across Populations (TRPCDP) was established in 2020 to address differences in cancer incidence and mortality rates within the United States, with a particular focus on colorectal …

The Translational Research Program in Cancer Differences across Populations

Jane C. Figueiredo, Diana Redwood, Li Li, Elizabeth Donato et autres

BACKGROUND: Cancer incidence and mortality vary substantially across populations. The Translational Research Program in Cancer Differences across Populations (TRPCDP) was established in 2020 to address differences in cancer incidence and mortality rates within the United States, with a particular focus on colorectal …

us (code pays fourni par la source)

Spatial proteomics and transcriptomics characterization of tissue and multiple cancer types including decalcified marrow

Cecilia C.S. Yeung, Daniel C. Jones, David W. Woolston, Brandon Seaton et autres

BackgroundRecent technologies enabling the study of spatial biology include multiple high-dimensional spatial imaging methods that have rapidly emerged with different capabilities evaluating tissues at different resolutions for different sample formats. Platforms like Xenium (10x Genomics) and PhenoCycler-Fusion (Akoya Biosciences) enable single-cell resolution …

us (code pays fourni par la source)

Data-driven flow cytometry classification of blast differentiation in older patients with acute myeloid leukemia

Catia Simoes, Carmen González, François Vergez, Audrey Sarry et autres

es, fr (code pays fourni par la source)

Abstract 3423: Spatial-resolved single-cell analysis of the tumor microenvironment in Alaska Native colorectal cancer patients

Hang Yin, Diana Redwood, Kimberly S. Smythe, Daniel C. Jones et autres

Abstract Tribal Health Organizations recognize the high rates of colorectal cancer (CRC) among Alaska Native peoples and are undertaking initiatives to address it. The tumor microenvironment (TME) is a complex ecosystem including tumor, stromal, and immune cells. Understanding the cell composition and …

us (code pays fourni par la source)

Figure S5 from Single-cell Profiling Uncovers a Muc4-Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori-driven Inflammation

Valerie P. O’Brien, Yuqi Kang, Meera K. Shenoy, Greg Finak et autres

The dysplasia marker gene Trop2 is rarely detected in the central epithelial megacluster, whereas Muc4 and Areg are primarily detected in the central epithelial megacluster.